Compile Data Set for Download or QSAR

Found 10 hits of ec50 for UniProtKB: P78536   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419177 (US10457678, Compound 33) Show SMILES CCOc1ccc(cc1)-c1cc2cccnc2n1C(=O)N1CCN(C1=O)S(C)(=O)=O Show InChI InChI=1S/C20H20N4O5S/c1-3-29-16-8-6-14(7-9-16)17-13-15-5-4-10-21-18(15)24(17)20(26)22-11-12-23(19(22)25)30(2,27)28/h4-10,13H,3,11-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419183 (US10457678, Compound 36) Show SMILES CCOc1ccc(cc1)-c1cc2cccn(C(=O)N3CCN(C)CC3)c2n1 Show InChI InChI=1S/C21H24N4O2/c1-3-27-18-8-6-16(7-9-18)19-15-17-5-4-10-25(20(17)22-19)21(26)24-13-11-23(2)12-14-24/h4-10,15H,3,11-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419140 (US10457678, Compound 10) Show SMILES CCOc1ccc(cc1)-c1cc2cccnc2n1C(C)=O Show InChI InChI=1S/C17H16N2O2/c1-3-21-15-8-6-13(7-9-15)16-11-14-5-4-10-18-17(14)19(16)12(2)20/h4-11H,3H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419178 (US10457678, Compound 34) Show SMILES CCOc1ccc(cc1)-c1cc2cccn(C(=O)N(C(C)C)C(C)C)c2n1 Show InChI InChI=1S/C22H27N3O2/c1-6-27-19-11-9-17(10-12-19)20-14-18-8-7-13-24(21(18)23-20)22(26)25(15(2)3)16(4)5/h7-16H,6H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419153 (US10457678, Compound 26) Show SMILES CCOc1ccc(cc1)-c1cc2c(Cl)ccnc2n1C(=O)OC(C)(C)C Show InChI InChI=1S/C20H21ClN2O3/c1-5-25-14-8-6-13(7-9-14)17-12-15-16(21)10-11-22-18(15)23(17)19(24)26-20(2,3)4/h6-12H,5H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419173 (US10457678, Compound 32) Show SMILES CCOc1ccc(cc1)-c1cc2cccnc2n1C(=O)OCC(Cl)(Cl)Cl Show InChI InChI=1S/C18H15Cl3N2O3/c1-2-25-14-7-5-12(6-8-14)15-10-13-4-3-9-22-16(13)23(15)17(24)26-11-18(19,20)21/h3-10H,2,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419141 (US10457678, Compound 17) Show SMILES CCOc1ccc(cc1)-c1cc2cccnc2n1C(=O)OC(C)(C)C Show InChI InChI=1S/C20H22N2O3/c1-5-24-16-10-8-14(9-11-16)17-13-15-7-6-12-21-18(15)22(17)19(23)25-20(2,3)4/h6-13H,5H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419182 (US10457678, Compound 35) Show SMILES CCOc1ccc(cc1)-c1cc2cccn(C(=O)N3CCCC3)c2n1 Show InChI InChI=1S/C20H21N3O2/c1-2-25-17-9-7-15(8-10-17)18-14-16-6-5-13-23(19(16)21-18)20(24)22-11-3-4-12-22/h5-10,13-14H,2-4,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419159 (US10457678, Compound 21) Show SMILES CCOc1ccc(cc1)-c1cc2cccn(C(=O)OCc3ccccc3)c2n1 Show InChI InChI=1S/C23H20N2O3/c1-2-27-20-12-10-18(11-13-20)21-15-19-9-6-14-25(22(19)24-21)23(26)28-16-17-7-4-3-5-8-17/h3-15H,2,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM419135 (US10457678, Compound 7) Show SMILES CCOc1ccc(cc1)-c1cc2cccn(C(=O)N(CC)CC)c2n1 Show InChI InChI=1S/C20H23N3O2/c1-4-22(5-2)20(24)23-13-7-8-16-14-18(21-19(16)23)15-9-11-17(12-10-15)25-6-3/h7-14H,4-6H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a
Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1 US Patent					Assay Description TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...				US Patent US10457678 (2019) BindingDB Entry DOI: 10.7270/Q2S184V0
					More data for this Ligand-Target Pair