Compile Data Set for Download or QSAR

Found 19 hits of ic50 for UniProtKB: P04629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515354 (US11098060, Example 12 | US11098060, Example 34) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515356 ((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515357 ((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...) Show SMILES C[C@H]1CNC(=O)c2c(N)nn3ccc(nc23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515368 ((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515367 (US11098060, Example 26) Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515361 ((13E,14E,22R,24S,6R)-12-amino-24, 35-difluoro-6-me...) Show SMILES C[C@@H]1COc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515358 ((13E,14E,22R,24S)-12-amino-24,35-difluoro- 4-oxa-9...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515351 ((13E,14E,22R,24R)-12-amino-35fluoro-24- hydroxy-4-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1[C@H]1C[C@@H](O)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515363 (US11098060, Example 21) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515369 ((13E,14E,22R,6R)-12-amino-35- fluoro-6-methyl-7-az...) Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.01	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515359 ((13E,14E,22R,24S)-12-amino-24,35-difluoro- 8-methy...) Show SMILES CN1CCCOc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C1=O)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515370 ((13E,14E,22R,24S,6S)-12-amino- 24,35-difluoro-6-me...) Show SMILES C[C@H]1CCc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.08	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515360 ((13E,14E,22R,24S)-12-amino-24,35-difluoro- 6,6-dim...) Show SMILES CC1(C)CNC(=O)c2c(N)nn3ccc(nc23)N2C[C@@H](F)CC2c2cc(F)cnc2OC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.24	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515372 ((13E,14E,22R,5S)-12-amino-35- fluoro-5-methyl-4-ox...) Show SMILES C[C@H]1CNC(=O)c2c(N)nn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2O1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515375 ((13E,14E,22R,24S)-12-amino-24,35,6,6- tetrafluoro-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCC(F)(F)COc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.36	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515365 (US11098060, Example 23) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCn1cc(F)cc([C@H]2C[C@H](F)CN32)c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515371 ((13E,14E,22R,24S)-12-amino- 24,35-difluoro-8-aza-1...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCCc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.45	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515352 ((R,13E,14E)-12-amino-35-fluro-4-oxa-8-aza- 1(5,3)-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ccc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.92	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human))	BDBM515350 ((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.08	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair