Compile Data Set for Download or QSAR

Found 11 hits of ic50 for UniProtKB: P05154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma serine protease inhibitor (Human)	BDBM528127 (US11180484, Example 79 | US11180484, Reference Exa...) Show SMILES COCc1nn(Cc2cnc(nc2)N2CCCC2)cc1C(=O)NCc1c(F)c(OC)ccc1-n1cnnn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528105 (N-{[2-fluoro-3-methoxy-6-(1,2,3,4-tetrazol-1-yl)ph...) Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)c(OC)ccc1-n1cnnn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528102 (3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1...) Show SMILES COc1ccc(F)c(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)c1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528103 (N-[(2-cyano-5-methoxyphenyl)methyl]-3-(methoxymeth...) Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528108 (N-[(6-carbamoyl-2-fluoro-3-methoxyphenyl)methyl]-3...) Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)c(OC)ccc1C(N)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528116 (N-[(6-cyano-2-fluoro-3-methoxyphenyl)methyl]-1-({4...) Show SMILES COCc1nn(Cc2ccc(Cn3cc(F)ccc3=O)cc2)cc1C(=O)NCc1c(F)c(OC)ccc1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528123 (N-{[5-chloro-2-(1,2,3,4-tetrazol-1-yl)phenyl]methy...) Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(Cl)ccc1-n1cnnn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528125 (3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl...) Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1-n1cnnn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528099 (1-({4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl}m...) Show SMILES COCc1nn(Cc2ccc(Cn3cc(F)ccc3=O)cc2)cc1C(=O)NCc1nccc(OC)c1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528084 (N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-1-({4-[...) Show SMILES COc1ccnc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C(F)(F)F)c1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair
Plasma serine protease inhibitor (Human)	BDBM528106 (N-{[5-methoxy-2-(1,2,3,4-tetrazol-1-yl)phenyl]meth...) Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1-n1cnnn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human serine protease enzymes plasmin, thrombin and trypsin were assayed for enzymatic activity using an appropriate fluorogenic substrate. Protease ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
					More data for this Ligand-Target Pair