Compile Data Set for Download or QSAR

Found 29 hits of ic50 for UniProtKB: P20417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085948 (2-(3-{3-[5-Phenyl-2-(4-trifluoromethyl-phenyl)-oxa...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2nc(oc2-c2ccccc2)-c2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C29H22F3N3O5/c1-18(14-15-35-27(36)34-28(37)40-35)21-8-5-9-23(16-21)38-17-24-25(19-6-3-2-4-7-19)39-26(33-24)20-10-12-22(13-11-20)29(30,31)32/h2-14,16H,15,17H2,1H3,(H,34,36,37)/b18-14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085938 (2-{3-[3-(3,5-Dichloro-benzyloxy)-phenyl]-hept-2-en...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2cc(Cl)cc(Cl)c2)c1 Show InChI InChI=1S/C22H22Cl2N2O4/c1-2-3-5-16(8-9-26-21(27)25-22(28)30-26)17-6-4-7-20(12-17)29-14-15-10-18(23)13-19(24)11-15/h4,6-8,10-13H,2-3,5,9,14H2,1H3,(H,25,27,28)/b16-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085965 (2-{3-[3-(2-Butyl-benzofuran-3-ylmethyl)-phenyl]-bu...) Show SMILES CCCCc1oc2ccccc2c1Cc1cccc(c1)C(\C)=C\Cn1oc(=O)[nH]c1=O Show InChI InChI=1S/C25H26N2O4/c1-3-4-11-23-21(20-10-5-6-12-22(20)30-23)16-18-8-7-9-19(15-18)17(2)13-14-27-24(28)26-25(29)31-27/h5-10,12-13,15H,3-4,11,14,16H2,1-2H3,(H,26,28,29)/b17-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085942 (2-{(E)-3-[3-(3,5-Dichloro-phenoxy)-phenyl]-hept-2-...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(Oc2cc(Cl)cc(Cl)c2)c1 Show InChI InChI=1S/C21H20Cl2N2O4/c1-2-3-5-14(8-9-25-20(26)24-21(27)29-25)15-6-4-7-18(10-15)28-19-12-16(22)11-17(23)13-19/h4,6-8,10-13H,2-3,5,9H2,1H3,(H,24,26,27)/b14-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085956 (2-[3-(4-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1ccc(OCCc2nc(oc2C)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H22F3N3O5/c1-15(11-13-31-23(32)30-24(33)36-31)17-5-9-20(10-6-17)34-14-12-21-16(2)35-22(29-21)18-3-7-19(8-4-18)25(26,27)28/h3-11H,12-14H2,1-2H3,(H,30,32,33)/b15-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085938 (2-{3-[3-(3,5-Dichloro-benzyloxy)-phenyl]-hept-2-en...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2cc(Cl)cc(Cl)c2)c1 Show InChI InChI=1S/C22H22Cl2N2O4/c1-2-3-5-16(8-9-26-21(27)25-22(28)30-26)17-6-4-7-20(12-17)29-14-15-10-18(23)13-19(24)11-15/h4,6-8,10-13H,2-3,5,9,14H2,1H3,(H,25,27,28)/b16-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant Protein-tyrosine phosphatase 1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085941 (2-[3-(3-Phenoxy-phenyl)-hept-2-enyl]-[1,2,4]oxadia...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C21H22N2O4/c1-2-3-8-16(13-14-23-20(24)22-21(25)27-23)17-9-7-12-19(15-17)26-18-10-5-4-6-11-18/h4-7,9-13,15H,2-3,8,14H2,1H3,(H,22,24,25)/b16-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085961 (2-{3-[3-(2-Butyl-benzofuran-3-ylmethoxy)-phenyl]-b...) Show SMILES CCCCc1oc2ccccc2c1COc1cccc(c1)C(\C)=C\Cn1oc(=O)[nH]c1=O Show InChI InChI=1S/C25H26N2O5/c1-3-4-11-23-21(20-10-5-6-12-22(20)31-23)16-30-19-9-7-8-18(15-19)17(2)13-14-27-24(28)26-25(29)32-27/h5-10,12-13,15H,3-4,11,14,16H2,1-2H3,(H,26,28,29)/b17-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085967 (2-{3-[3-(5-Phenyl-[1,2,4]oxadiazol-3-ylmethoxy)-ph...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2noc(n2)-c2ccccc2)c1 Show InChI InChI=1S/C21H18N4O5/c1-14(10-11-25-20(26)23-21(27)30-25)16-8-5-9-17(12-16)28-13-18-22-19(29-24-18)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,23,26,27)/b14-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085958 (2-(3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxa...) Show SMILES C\C(=C/Cn1sc(=O)[nH]c1=O)c1cccc(OCc2nc(oc2C)-c2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C24H20F3N3O4S/c1-14(10-11-30-22(31)29-23(32)35-30)17-4-3-5-19(12-17)33-13-20-15(2)34-21(28-20)16-6-8-18(9-7-16)24(25,26)27/h3-10,12H,11,13H2,1-2H3,(H,29,31,32)/b14-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085960 (2-{(E)-3-[3-(3,5-Bis-trifluoromethyl-benzyloxy)-ph...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C21H16F6N2O4/c1-12(5-6-29-18(30)28-19(31)33-29)14-3-2-4-17(9-14)32-11-13-7-15(20(22,23)24)10-16(8-13)21(25,26)27/h2-5,7-10H,6,11H2,1H3,(H,28,30,31)/b12-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50440661 (CHEMBL2430649) Show SMILES FC(F)(F)c1ccc(cc1)-n1cc(COc2ccc(cc2)-c2nc3c(ccc4ccccc34)o2)nn1 Show InChI InChI=1S/C27H17F3N4O2/c28-27(29,30)19-8-10-21(11-9-19)34-15-20(32-33-34)16-35-22-12-5-18(6-13-22)26-31-25-23-4-2-1-3-17(23)7-14-24(25)36-26/h1-15H,16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	8.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PTP1B in rat liver homogenates using p-nitro phenyl phosphate as substrate preincubated for 30 mins followed by substrate addition meas...				Citation and Details Article DOI: 10.1007/s00044-013-0784-0 BindingDB Entry DOI: 10.7270/Q2T43VJ3
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085952 (2-{3-[3-(4-Methoxy-phenoxy)-phenyl]-hept-2-enyl}-[...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(Oc2ccc(OC)cc2)c1 Show InChI InChI=1S/C22H24N2O5/c1-3-4-6-16(13-14-24-21(25)23-22(26)29-24)17-7-5-8-20(15-17)28-19-11-9-18(27-2)10-12-19/h5,7-13,15H,3-4,6,14H2,1-2H3,(H,23,25,26)/b16-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085963 (2-{(E)-3-[3-(3,5-Bis-trifluoromethyl-phenoxymethyl...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(COc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C21H16F6N2O4/c1-12(5-6-29-18(30)28-19(31)33-29)14-4-2-3-13(7-14)11-32-17-9-15(20(22,23)24)8-16(10-17)21(25,26)27/h2-5,7-10H,6,11H2,1H3,(H,28,30,31)/b12-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085939 (2-[3-(3-p-Tolyloxy-phenyl)-hept-2-enyl]-[1,2,4]oxa...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(Oc2ccc(C)cc2)c1 Show InChI InChI=1S/C22H24N2O4/c1-3-4-6-17(13-14-24-21(25)23-22(26)28-24)18-7-5-8-20(15-18)27-19-11-9-16(2)10-12-19/h5,7-13,15H,3-4,6,14H2,1-2H3,(H,23,25,26)/b17-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085945 (1-(3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxa...) Show SMILES C\C(=C/Cn1cc(O)[nH]c1=O)c1cccc(OCc2nc(oc2C)-c2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C25H22F3N3O4/c1-15(10-11-31-13-22(32)30-24(31)33)18-4-3-5-20(12-18)34-14-21-16(2)35-23(29-21)17-6-8-19(9-7-17)25(26,27)28/h3-10,12-13,32H,11,14H2,1-2H3,(H,30,33)/b15-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085955 (2-{3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2ccc3c(Cl)cccc3c2)c1 Show InChI InChI=1S/C23H19ClN2O4/c1-15(10-11-26-22(27)25-23(28)30-26)17-4-2-6-19(13-17)29-14-16-8-9-20-18(12-16)5-3-7-21(20)24/h2-10,12-13H,11,14H2,1H3,(H,25,27,28)/b15-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085949 (2-(3-{3-[2-(4-Trifluoromethyl-phenyl)-oxazol-4-ylm...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2coc(n2)-c2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C23H18F3N3O5/c1-14(9-10-29-21(30)28-22(31)34-29)16-3-2-4-19(11-16)32-12-18-13-33-20(27-18)15-5-7-17(8-6-15)23(24,25)26/h2-9,11,13H,10,12H2,1H3,(H,28,30,31)/b14-9+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50440662 (CHEMBL2430648) Show SMILES Cc1ccc(cc1)-n1cc(COc2ccc(cc2)-c2nc3c(ccc4ccccc34)o2)nn1 Show InChI InChI=1S/C27H20N4O2/c1-18-6-11-22(12-7-18)31-16-21(29-30-31)17-32-23-13-8-20(9-14-23)27-28-26-24-5-3-2-4-19(24)10-15-25(26)33-27/h2-16H,17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PTP1B in rat liver homogenates using p-nitro phenyl phosphate as substrate preincubated for 30 mins followed by substrate addition meas...				Citation and Details Article DOI: 10.1007/s00044-013-0784-0 BindingDB Entry DOI: 10.7270/Q2T43VJ3
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085942 (2-{(E)-3-[3-(3,5-Dichloro-phenoxy)-phenyl]-hept-2-...) Show SMILES CCCC\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(Oc2cc(Cl)cc(Cl)c2)c1 Show InChI InChI=1S/C21H20Cl2N2O4/c1-2-3-5-14(8-9-25-20(26)24-21(27)29-25)15-6-4-7-18(10-15)28-19-12-16(22)11-17(23)13-19/h4,6-8,10-13H,2-3,5,9H2,1H3,(H,24,26,27)/b14-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085959 (2-(3-{3-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCCc2nc(oc2C)-c2ccccc2)c1 Show InChI InChI=1S/C24H23N3O5/c1-16(11-13-27-23(28)26-24(29)32-27)19-9-6-10-20(15-19)30-14-12-21-17(2)31-22(25-21)18-7-4-3-5-8-18/h3-11,15H,12-14H2,1-2H3,(H,26,28,29)/b16-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085950 (2-(4,4-Dimethyl-3-{3-[5-methyl-2-(4-trifluoromethy...) Show SMILES Cc1oc(nc1COc1cccc(c1)C(=C\Cn1oc(=O)[nH]c1=O)\C(C)(C)C)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C27H26F3N3O5/c1-16-22(31-23(37-16)17-8-10-19(11-9-17)27(28,29)30)15-36-20-7-5-6-18(14-20)21(26(2,3)4)12-13-33-24(34)32-25(35)38-33/h5-12,14H,13,15H2,1-4H3,(H,32,34,35)/b21-12-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085969 (2-(3-{3-[3-(3,5-Bis-trifluoromethyl-phenyl)-prop-2...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCC#Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C23H16F6N2O4/c1-14(7-8-31-20(32)30-21(33)35-31)16-5-2-6-19(12-16)34-9-3-4-15-10-17(22(24,25)26)13-18(11-15)23(27,28)29/h2,5-7,10-13H,8-9H2,1H3,(H,30,32,33)/b14-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Concentration required to inhibit PTPase activity, recombinant r-PTP1B as the enzyme at a concentration 2.5 uM .				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085946 (2-(3-(4-Chloro-phenyl)-3-{3-[5-methyl-2-(4-trifluo...) Show SMILES Cc1oc(nc1COc1cccc(c1)C(=C\Cn1oc(=O)[nH]c1=O)\c1ccc(Cl)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C29H21ClF3N3O5/c1-17-25(34-26(40-17)19-5-9-21(10-6-19)29(31,32)33)16-39-23-4-2-3-20(15-23)24(18-7-11-22(30)12-8-18)13-14-36-27(37)35-28(38)41-36/h2-13,15H,14,16H2,1H3,(H,35,37,38)/b24-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085966 (2-(3-(4-Fluoro-phenyl)-3-{3-[5-methyl-2-(4-trifluo...) Show SMILES Cc1oc(nc1COc1cccc(c1)C(=C\Cn1oc(=O)[nH]c1=O)\c1ccc(F)cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C29H21F4N3O5/c1-17-25(34-26(40-17)19-5-9-21(10-6-19)29(31,32)33)16-39-23-4-2-3-20(15-23)24(18-7-11-22(30)12-8-18)13-14-36-27(37)35-28(38)41-36/h2-13,15H,14,16H2,1H3,(H,35,37,38)/b24-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085961 (2-{3-[3-(2-Butyl-benzofuran-3-ylmethoxy)-phenyl]-b...) Show SMILES CCCCc1oc2ccccc2c1COc1cccc(c1)C(\C)=C\Cn1oc(=O)[nH]c1=O Show InChI InChI=1S/C25H26N2O5/c1-3-4-11-23-21(20-10-5-6-12-22(20)31-23)16-30-19-9-7-8-18(15-19)17(2)13-14-27-24(28)26-25(29)32-27/h5-10,12-13,15H,3-4,11,14,16H2,1-2H3,(H,26,28,29)/b17-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085957 (2-(3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxa...) Show SMILES C\C(=C/Cn1oc(=O)[nH]c1=O)c1ccccc1OCc1nc(oc1C)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H20F3N3O5/c1-14(11-12-30-22(31)29-23(32)35-30)18-5-3-4-6-20(18)33-13-19-15(2)34-21(28-19)16-7-9-17(10-8-16)24(25,26)27/h3-11H,12-13H2,1-2H3,(H,29,31,32)/b14-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085964 (5-(3-{3-[5-Methyl-2-(4-trifluoromethoxy-phenyl)-ox...) Show SMILES C\C(=C/Cc1oc(=O)[nH]c1O)c1cccc(OCc2nc(oc2C)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C25H21F3N2O6/c1-14(6-11-21-22(31)30-24(32)35-21)17-4-3-5-19(12-17)33-13-20-15(2)34-23(29-20)16-7-9-18(10-8-16)36-25(26,27)28/h3-10,12,31H,11,13H2,1-2H3,(H,30,32)/b14-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Rattus norvegicus (rat))	BDBM50085940 (2-(2-Methyl-3-{3-[5-methyl-2-(4-trifluoromethyl-ph...) Show SMILES C\C(Cn1oc(=O)[nH]c1=O)=C/c1cccc(OCc2nc(oc2C)-c2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C24H20F3N3O5/c1-14(12-30-22(31)29-23(32)35-30)10-16-4-3-5-19(11-16)33-13-20-15(2)34-21(28-20)17-6-8-18(9-7-17)24(25,26)27/h3-11H,12-13H2,1-2H3,(H,29,31,32)/b14-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrate				J Med Chem 43: 995-1010 (2000) BindingDB Entry DOI: 10.7270/Q2H70F1H
					More data for this Ligand-Target Pair