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Compile Data Set for Download or QSAR

Found 264 hits of ic50 for UniProtKB: P42227   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20242
PNG
(4-[(2S)-2-{[(2S)-1-[(1R,2S,5S)-2-{[(1S)-1-(benzylc...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CCc1ccccc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C42H53N6O10P/c1-26(2)21-35(47-40(52)34(45-37(50)20-15-27-9-5-3-6-10-27)22-28-13-16-31(17-14-28)58-59(55,56)57)42(54)48-25-30-23-32(30)38(48)41(53)46-33(18-19-36(43)49)39(51)44-24-29-11-7-4-8-12-29/h3-14,16-17,26,30,32-35,38H,15,18-25H2,1-2H3,(H2,43,49)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H2,55,56,57)/t30-,32-,33+,34+,35+,38+/m1/s1
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n/an/a 125n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O |r|
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a 150n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20211
PNG
(18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1 |...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H48N7O12P/c1-15(2)11-24(37-30(45)23(35-17(4)41)12-18-5-7-20(8-6-18)51-52(48,49)50)32(47)39-14-19-13-21(19)27(39)31(46)36-22(9-10-25(33)42)29(44)38-26(16(3)40)28(34)43/h5-8,15-16,19,21-24,26-27,40H,9-14H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t16?,19-,21-,22+,23+,24+,26+,27+/m1/s1
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n/an/a 265n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20200
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C38H54N7O12P/c1-22(2)20-29(38(53)45-19-7-10-30(45)37(52)42-27(16-17-31(39)47)35(50)44-33(23(3)46)34(40)49)43-36(51)28(41-32(48)18-13-24-8-5-4-6-9-24)21-25-11-14-26(15-12-25)57-58(54,55)56/h4-6,8-9,11-12,14-15,22-23,27-30,33,46H,7,10,13,16-21H2,1-3H3,(H2,39,47)(H2,40,49)(H,41,48)(H,42,52)(H,43,51)(H,44,50)(H2,54,55,56)/t23?,27-,28-,29-,30-,33-/m0/s1
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n/an/a 276n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O |r|
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549118
PNG
(BDBM50556884 | US11299480, Example 53)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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TBA

Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20253
PNG
(LIFR (1001) derived peptide, 9 | Y(p)KPQMH)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r|
Show InChI InChI=1S/C38H58N11O12PS/c1-22(50)44-30(18-23-8-10-25(11-9-23)61-62(58,59)60)36(55)47-28(6-3-4-15-39)38(57)49-16-5-7-31(49)37(56)46-26(12-13-32(40)51)34(53)45-27(14-17-63-2)35(54)48-29(33(41)52)19-24-20-42-21-43-24/h8-11,20-21,26-31H,3-7,12-19,39H2,1-2H3,(H2,40,51)(H2,41,52)(H,42,43)(H,44,50)(H,45,53)(H,46,56)(H,47,55)(H,48,54)(H2,58,59,60)/t26-,27-,28-,29-,30-,31-/m0/s1
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n/an/a 400n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20266
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C)C(N)=O |r|
Show InChI InChI=1S/C34H53N8O13P/c1-17(2)15-25(40-31(48)24(38-20(5)44)16-21-8-10-22(11-9-21)55-56(52,53)54)34(51)42-14-6-7-26(42)32(49)39-23(12-13-27(35)45)30(47)41-28(19(4)43)33(50)37-18(3)29(36)46/h8-11,17-19,23-26,28,43H,6-7,12-16H2,1-5H3,(H2,35,45)(H2,36,46)(H,37,50)(H,38,44)(H,39,49)(H,40,48)(H,41,47)(H2,52,53,54)/t18-,19?,23-,24-,25-,26-,28-/m0/s1
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The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20233
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C34H47N6O10P/c1-21(2)18-28(39-32(44)27(37-22(3)41)19-23-11-13-25(14-12-23)50-51(47,48)49)34(46)40-17-7-10-29(40)33(45)38-26(15-16-30(35)42)31(43)36-20-24-8-5-4-6-9-24/h4-6,8-9,11-14,21,26-29H,7,10,15-20H2,1-3H3,(H2,35,42)(H,36,43)(H,37,41)(H,38,45)(H,39,44)(H2,47,48,49)/t26-,27-,28-,29-/m0/s1
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The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556886
PNG
(CHEMBL4753422)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ncc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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TBA

Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549121
PNG
(BDBM50556885 | US11299480, Example 133)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1cnc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20210
PNG
(17, Ac-pTyr-Leu-4-hydroxy-Pro-Gln-Thr-NH2 | 4-[(2S...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C31H48N7O13P/c1-15(2)11-23(36-29(45)22(34-17(4)40)12-18-5-7-20(8-6-18)51-52(48,49)50)31(47)38-14-19(41)13-24(38)30(46)35-21(9-10-25(32)42)28(44)37-26(16(3)39)27(33)43/h5-8,15-16,19,21-24,26,39,41H,9-14H2,1-4H3,(H2,32,42)(H2,33,43)(H,34,40)(H,35,46)(H,36,45)(H,37,44)(H2,48,49,50)/t16?,19-,21+,22+,23+,24+,26+/m1/s1
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n/an/a 484n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20198
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CCC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C32H50N7O12P/c1-5-26(42)35-22(16-19-8-10-20(11-9-19)51-52(48,49)50)30(45)37-23(15-17(2)3)32(47)39-14-6-7-24(39)31(46)36-21(12-13-25(33)41)29(44)38-27(18(4)40)28(34)43/h8-11,17-18,21-24,27,40H,5-7,12-16H2,1-4H3,(H2,33,41)(H2,34,43)(H,35,42)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t18?,21-,22-,23-,24-,27-/m0/s1
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The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549075
PNG
(BDBM50556877 | US11299480, Example 34)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cc1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556879
PNG
(CHEMBL4752153)
Show SMILES [Na;v0+].[#8]-c1cc(-[#7](-[#6]-c2ccc(cc2)-[#6]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6](=O)-[#6@H]-2-[#6]-[#6]-[#7]-2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c(F)cc1-[#6](-[#8-])=O |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556876
PNG
(CHEMBL4743282)
Show SMILES [Na;v0+].[#8]-c1cc(ccc1-[#6](-[#8-])=O)-[#7](-[#6]-c1ccc(cc1)-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#6](=O)-[#6@H]-1-[#6]-[#6]-[#7]-1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20234
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C35H49N6O10P/c1-21(2)19-29(40-33(45)28(38-23(4)42)20-24-12-14-26(15-13-24)51-52(48,49)50)35(47)41-18-8-11-30(41)34(46)39-27(16-17-31(36)43)32(44)37-22(3)25-9-6-5-7-10-25/h5-7,9-10,12-15,21-22,27-30H,8,11,16-20H2,1-4H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,48,49,50)/t22-,27-,28-,29-,30-/m0/s1
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n/an/a 596n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 600n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549103
PNG
(BDBM50556888 | US11299480, Example 125)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cn1)C1CCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556882
PNG
(CHEMBL4786885)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(nc1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556878
PNG
(CHEMBL4742343)
Show SMILES OC(=O)c1cc(F)c(cc1O)N(Cc1ccc(cc1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556887
PNG
(CHEMBL4799226)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(nn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556875
PNG
(CHEMBL4754054 | US11299480, Example 80)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cc1)C1CCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20205
PNG
(12, Ac-pTyr-Nle-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C31H48N7O12P/c1-4-5-7-22(36-29(44)23(34-18(3)40)16-19-9-11-20(12-10-19)50-51(47,48)49)31(46)38-15-6-8-24(38)30(45)35-21(13-14-25(32)41)28(43)37-26(17(2)39)27(33)42/h9-12,17,21-24,26,39H,4-8,13-16H2,1-3H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 717n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 739n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20236
PNG
((2S)-4-carbamoyl-2-{[(2S)-1-[(2S)-2-[(2S)-2-acetam...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O |r|
Show InChI InChI=1S/C27H40N5O11P/c1-15(2)13-21(26(37)32-12-4-5-22(32)25(36)30-19(27(38)39)10-11-23(28)34)31-24(35)20(29-16(3)33)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,34)(H,29,33)(H,30,36)(H,31,35)(H,38,39)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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n/an/a 748n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20199
PNG
(4-[(2S)-2-{[(benzyloxy)carbonyl]amino}-2-{[(2S)-1-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C37H52N7O13P/c1-21(2)18-28(36(51)44-17-7-10-29(44)35(50)40-26(15-16-30(38)46)33(48)43-31(22(3)45)32(39)47)41-34(49)27(42-37(52)56-20-24-8-5-4-6-9-24)19-23-11-13-25(14-12-23)57-58(53,54)55/h4-6,8-9,11-14,21-22,26-29,31,45H,7,10,15-20H2,1-3H3,(H2,38,46)(H2,39,47)(H,40,50)(H,41,49)(H,42,52)(H,43,48)(H2,53,54,55)/t22?,26-,27-,28-,29-,31-/m0/s1
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n/an/a 750n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556897
PNG
(CHEMBL4743428)
Show SMILES OC(=O)c1ccc(N(Cc2ccc(cn2)C2CCCCC2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c(F)c1 |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556889
PNG
(CHEMBL4788858)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1cnc(cn1)C1CCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20265
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O |r|
Show InChI InChI=1S/C35H55N8O12P/c1-18(2)16-26(41-33(49)25(39-21(6)44)17-22-9-11-23(12-10-22)55-56(52,53)54)35(51)43-15-7-8-27(43)34(50)40-24(13-14-28(36)45)32(48)38-20(5)31(47)42-29(19(3)4)30(37)46/h9-12,18-20,24-27,29H,7-8,13-17H2,1-6H3,(H2,36,45)(H2,37,46)(H,38,48)(H,39,44)(H,40,50)(H,41,49)(H,42,47)(H2,52,53,54)/t20-,24-,25-,26-,27-,29-/m0/s1
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n/an/a 800n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20235
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C35H49N6O10P/c1-21(2)19-29(40-33(45)28(38-23(4)42)20-24-12-14-26(15-13-24)51-52(48,49)50)35(47)41-18-8-11-30(41)34(46)39-27(16-17-31(36)43)32(44)37-22(3)25-9-6-5-7-10-25/h5-7,9-10,12-15,21-22,27-30H,8,11,16-20H2,1-4H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,48,49,50)/t22-,27+,28+,29+,30+/m1/s1
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n/an/a 801n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549310
PNG
(BDBM50556881 | US11299480, Example 64)
Show SMILES OC(=O)c1cc(F)c(cc1O)N(Cc1ccc(cc1)C1CCOCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20197
PNG
(4, Benzoyl-pTyr-Leu -Pro-Gln-Thr-NH2 | 4-[(2S)-2-{...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C36H50N7O12P/c1-20(2)18-27(36(51)43-17-7-10-28(43)35(50)39-25(15-16-29(37)45)33(48)42-30(21(3)44)31(38)46)41-34(49)26(40-32(47)23-8-5-4-6-9-23)19-22-11-13-24(14-12-22)55-56(52,53)54/h4-6,8-9,11-14,20-21,25-28,30,44H,7,10,15-19H2,1-3H3,(H2,37,45)(H2,38,46)(H,39,50)(H,40,47)(H,41,49)(H,42,48)(H2,52,53,54)/t21?,25-,26-,27-,28-,30-/m0/s1
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n/an/a 814n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20196
PNG
(3, Ac-pTyr-Leu-Pro-Gln-NH2 | 4-[(2S)-2-{[(2S)-1-[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O |r|
Show InChI InChI=1S/C27H41N6O10P/c1-15(2)13-21(27(39)33-12-4-5-22(33)26(38)31-19(24(29)36)10-11-23(28)35)32-25(37)20(30-16(3)34)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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n/an/a 856n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549083
PNG
(BDBM50556898 | US11299480, Example 116)
Show SMILES OC(=O)c1ccc(cc1F)N(Cc1ccc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20232
PNG
(39, Ac-pTyr-Leu-Pro-Gln-NHMe | 4-[(2S)-2-{[(2S)-1-...)
Show SMILES CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O |r|
Show InChI InChI=1S/C28H43N6O10P/c1-16(2)14-22(28(40)34-13-5-6-23(34)27(39)32-20(25(37)30-4)11-12-24(29)36)33-26(38)21(31-17(3)35)15-18-7-9-19(10-8-18)44-45(41,42)43/h7-10,16,20-23H,5-6,11-15H2,1-4H3,(H2,29,36)(H,30,37)(H,31,35)(H,32,39)(H,33,38)(H2,41,42,43)/t20-,21-,22-,23-/m0/s1
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n/an/a 882n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556883
PNG
(CHEMBL4758974)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(nc1)C1CCOCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20204
PNG
(11, Ac-pTyr-Cha-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O |r|
Show InChI InChI=1S/C34H52N7O12P/c1-19(42)29(30(36)45)40-31(46)24(14-15-28(35)44)38-33(48)27-9-6-16-41(27)34(49)26(18-21-7-4-3-5-8-21)39-32(47)25(37-20(2)43)17-22-10-12-23(13-11-22)53-54(50,51)52/h10-13,19,21,24-27,29,42H,3-9,14-18H2,1-2H3,(H2,35,44)(H2,36,45)(H,37,43)(H,38,48)(H,39,47)(H,40,46)(H2,50,51,52)/t19?,24-,25-,26-,27-,29-/m0/s1
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n/an/a 910n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20254
PNG
(4-[(2S)-2-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1S...)
Show SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8]P([#8])([#8])=O)cc1)-[#7]-[#6](-[#6])=O)-[#6](-[#7])=O |r|
Show InChI InChI=1S/C35H56N11O12PS/c1-19(30(50)43-23(29(37)49)14-17-60-3)41-31(51)24(12-13-28(36)48)44-33(53)27-7-5-16-46(27)34(54)25(6-4-15-40-35(38)39)45-32(52)26(42-20(2)47)18-21-8-10-22(11-9-21)58-59(55,56)57/h8-11,19,23-27H,4-7,12-18H2,1-3H3,(H2,36,48)(H2,37,49)(H,41,51)(H,42,47)(H,43,50)(H,44,53)(H,45,52)(H4,38,39,40)(H2,55,56,57)/t19-,23-,24-,25-,26-,27-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20196
PNG
(3, Ac-pTyr-Leu-Pro-Gln-NH2 | 4-[(2S)-2-{[(2S)-1-[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O |r|
Show InChI InChI=1S/C27H41N6O10P/c1-15(2)13-21(27(39)33-12-4-5-22(33)26(38)31-19(24(29)36)10-11-23(28)35)32-25(37)20(30-16(3)34)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...

Bioorg Med Chem Lett 13: 633-6 (2003)


Article DOI: 10.1016/S0960-894X(02)01050-8
BindingDB Entry DOI: 10.7270/Q2K35RX1
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549058
PNG
(BDBM50556905 | US11299480, Example 107)
Show SMILES COC(=O)c1ccc(cc1O)N(Cc1ccc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20202
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C31H48N7O12P/c1-5-16(2)25(36-29(44)22(34-18(4)40)15-19-8-10-20(11-9-19)50-51(47,48)49)31(46)38-14-6-7-23(38)30(45)35-21(12-13-24(32)41)28(43)37-26(17(3)39)27(33)42/h8-11,16-17,21-23,25-26,39H,5-7,12-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t16?,17?,21-,22-,23-,25-,26-/m0/s1
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n/an/a 1.07E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556895
PNG
(CHEMBL4760561)
Show SMILES OC(=O)c1ccc(N(Cc2ccc(cc2)C2CCCCC2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c(F)c1 |r|
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n/an/a 1.08E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549099
PNG
(BDBM50556892 | US11299480, Example 123)
Show SMILES OC(=O)c1ccc(cc1)N(Cc1ccc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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n/an/a 1.09E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556873
PNG
(CHEMBL4793287)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cc1)C1CCOCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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n/an/a 1.09E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556904
PNG
(CHEMBL4763364)
Show SMILES COC(=O)c1ccc(cc1O)N(Cc1ccc(nc1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |r|
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n/an/a 1.10E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM549101
PNG
(BDBM50556899 | US11299480, Example 124)
Show SMILES OC(=O)c1ccc(N(Cc2ccc(cn2)C2CCCC2)C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c(F)c1 |r|
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n/an/a 1.18E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20241
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(37-29(44)23(35-19(4)41)16-20-8-10-21(11-9-20)51-52(48,49)50)32(47)39-14-6-7-25(39)30(45)36-22(12-13-26(33)42)31(46)38(5)27(18(3)40)28(34)43/h8-11,17-18,22-25,27,40H,6-7,12-16H2,1-5H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,45)(H,37,44)(H2,48,49,50)/t18?,22-,23-,24-,25-,27-/m0/s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM20214
PNG
(21, Ac-pTyr-Leu-Pip-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O |r|
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(37-30(45)23(35-19(4)41)16-20-8-10-21(11-9-20)51-52(48,49)50)32(47)39-14-6-5-7-25(39)31(46)36-22(12-13-26(33)42)29(44)38-27(18(3)40)28(34)43/h8-11,17-18,22-25,27,40H,5-7,12-16H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t18?,22-,23-,24-,25-,27-/m0/s1
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n/an/a 1.24E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...

J Med Chem 48: 6661-70 (2005)


Article DOI: 10.1021/jm050513m
BindingDB Entry DOI: 10.7270/Q2TH8JZF
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Mus musculus (mouse))		BDBM50556880
PNG
(CHEMBL4796668 | US11299480, Example 63)
Show SMILES CC(C)c1ccc(CN(C(=O)[C@H]2CCN2S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2cc(O)c(cc2F)C(O)=O)cc1 |r|
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n/an/a 1.28E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01705
BindingDB Entry DOI: 10.7270/Q2Z89H31
More data for this
Ligand-Target Pair
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