Compile Data Set for Download or QSAR

Found 218 hits of kd data for polymerid = 2737,2739   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399679 (US10323036, Compound I-123 | US10793574, Compound ...) Show SMILES COc1c(Nc2cc(Nc3cc(C)nc(C)n3)nc3[nH]n(C)c(=O)c23)cccc1-c1ccn(C)n1 Show InChI InChI=1S/C24H25N9O2/c1-13-11-19(26-14(2)25-13)28-20-12-18(21-23(29-20)31-33(4)24(21)34)27-17-8-6-7-15(22(17)35-5)16-9-10-32(3)30-16/h6-12H,1-5H3,(H3,25,26,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399682 (US10323036, Compound I-126 | US10793574, Compound ...) Show SMILES COCc1ccnc(Nc2cc(Nc3cccc(C(N)=O)c3OC)c3c(n2)[nH]n(C)c3=O)c1 Show InChI InChI=1S/C22H23N7O4/c1-29-22(31)18-15(25-14-6-4-5-13(20(23)30)19(14)33-3)10-17(27-21(18)28-29)26-16-9-12(11-32-2)7-8-24-16/h4-10H,11H2,1-3H3,(H2,23,30)(H3,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399685 (US10323036, Compound I-129 | US10793574, Compound ...) Show SMILES CN(c1ccccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)S(C)(=O)=O Show InChI InChI=1S/C19H22N6O4S/c1-24-19(27)16-13(10-15(21-17(16)23-24)22-18(26)11-8-9-11)20-12-6-4-5-7-14(12)25(2)30(3,28)29/h4-7,10-11H,8-9H2,1-3H3,(H3,20,21,22,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399689 (US10323036, Compound I-133 | US10793574, Compound ...) Show SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1cnc[nH]1 Show InChI InChI=1S/C23H21FN8O2/c1-12-7-18(26-9-14(12)24)29-19-8-16(20-22(30-19)31-32(2)23(20)33)28-15-6-4-5-13(21(15)34-3)17-10-25-11-27-17/h4-11H,1-3H3,(H,25,27)(H3,26,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399692 (US10323036, Compound I-136 | US10793574, Compound ...) Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2ccn(C)n2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C18H18ClN7O2/c1-25-8-7-13(23-25)21-14-9-12(15-17(22-14)24-26(2)18(15)27)20-11-6-4-5-10(19)16(11)28-3/h4-9H,1-3H3,(H3,20,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399695 (US10323036, Compound I-139 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3ccc(cn3)C#N)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C20H17N7O3S/c1-27-20(28)18-14(23-13-5-3-4-6-15(13)31(2,29)30)9-17(25-19(18)26-27)24-16-8-7-12(10-21)11-22-16/h3-9,11H,1-2H3,(H3,22,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399705 (US10323036, Compound I-149 | US10793574, Compound ...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-n1nc(C)c(C)n1 Show InChI InChI=1S/C22H24N8O3/c1-11-12(2)27-30(26-11)16-7-5-6-14(19(16)33-4)23-15-10-17(25-21(31)13-8-9-13)24-20-18(15)22(32)29(3)28-20/h5-7,10,13H,8-9H2,1-4H3,(H3,23,24,25,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399714 (US10323036, Compound I-191 | US10793574, Compound ...) Show SMILES COc1c(F)cccc1Nc1cc(Nc2ccc(C(F)F)c(n2)C#N)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C21H16F3N7O2/c1-31-21(32)17-13(26-12-5-3-4-11(22)18(12)33-2)8-16(29-20(17)30-31)28-15-7-6-10(19(23)24)14(9-25)27-15/h3-8,19H,1-2H3,(H3,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399718 (US10323036, Compound I-203 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3cccc(n3)C#N)cc(Nc3ccc(Cl)cc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C20H16ClN7O3S/c1-28-20(29)18-14(24-13-7-6-11(21)8-15(13)32(2,30)31)9-17(26-19(18)27-28)25-16-5-3-4-12(10-22)23-16/h3-9H,1-2H3,(H3,23,24,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399725 (US10323036, Compound I-212 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3cncc(n3)C#N)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O Show InChI InChI=1S/C22H20N8O3S/c1-30-22(31)20-16(26-15-6-5-13(12-3-4-12)7-17(15)34(2,32)33)8-18(28-21(20)29-30)27-19-11-24-10-14(9-23)25-19/h5-8,10-12H,3-4H2,1-2H3,(H3,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399734 (US10323036, Compound I-221 | US10793574, Compound ...) Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2cc3COCCn3n2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C20H20ClN7O3/c1-27-20(29)17-14(22-13-5-3-4-12(21)18(13)30-2)9-15(24-19(17)26-27)23-16-8-11-10-31-7-6-28(11)25-16/h3-5,8-9H,6-7,10H2,1-2H3,(H3,22,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399736 (US10323036, Compound I-223 | US10793574, Compound ...) Show SMILES COc1cccnc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C17H18N6O3/c1-23-17(25)13-10(19-14-11(26-2)4-3-7-18-14)8-12(20-15(13)22-23)21-16(24)9-5-6-9/h3-4,7-9H,5-6H2,1-2H3,(H3,18,19,20,21,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399745 (US10323036, Compound I-234 | US10793574, Compound ...) Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C1CCOCC1)S(C)(=O)=O Show InChI InChI=1S/C24H30N6O5S/c1-29-24(32)21-18(13-20(26-22(21)28-29)27-23(31)15-4-5-15)25-17-7-6-16(14-8-10-35-11-9-14)12-19(17)30(2)36(3,33)34/h6-7,12-15H,4-5,8-11H2,1-3H3,(H3,25,26,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399748 (US10323036, Compound I-237 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(NC(=O)[C@@H]3CC3(F)F)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399749 (US10323036, Compound I-238 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(NC(=O)[C@H]3CC3(F)F)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399754 (US10323036, Compound VIII-2 | US10793574, Compound...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2ncc(F)s2)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C21H19FN8O2S/c1-30-28-19(27-29-30)12-4-3-5-14(18(12)32-2)25-15-8-17(26-20(31)11-6-7-11)23-9-13(15)21-24-10-16(22)33-21/h3-5,8-11H,6-7H2,1-2H3,(H2,23,25,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399765 (US10323036, Compound VIII-13 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C#N)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C24H20N10O3/c1-34-13-27-23(33-34)15-6-4-7-17(22(15)36-2)29-18-9-20(30-19-8-3-5-14(10-25)28-19)26-11-16(18)24-32-31-21(12-35)37-24/h3-9,11,13,35H,12H2,1-2H3,(H2,26,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399767 (US10323036, Compound VIII-15 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C#N)ncc2-c2ncc(Cl)s2)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C23H17ClN10OS/c1-34-32-22(31-33-34)14-6-4-7-16(21(14)35-2)29-17-9-20(30-19-8-3-5-13(10-25)28-19)26-11-15(17)23-27-12-18(24)36-23/h3-9,11-12H,1-2H3,(H2,26,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399771 (US10323036, Compound XVI-2 | US10793574, Compound ...) Show SMILES CNc1nc(-c2cccc(-c3nnn(C)n3)c2OC)n2cc(NC(=O)C3CC3)ncc12 Show InChI InChI=1S/C20H21N9O2/c1-21-18-14-9-22-15(23-20(30)11-7-8-11)10-29(14)19(24-18)13-6-4-5-12(16(13)31-3)17-25-27-28(2)26-17/h4-6,9-11,21H,7-8H2,1-3H3,(H,23,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399774 (US10323036, Compound XVI-5 | US10793574, Compound ...) Show SMILES CCn1nc(-c2cccc(-c3nnn(C)n3)c2OC)c2cc(NC(=O)C3CC3)ncc12 Show InChI InChI=1S/C21H22N8O2/c1-4-29-16-11-22-17(23-21(30)12-8-9-12)10-15(16)18(25-29)13-6-5-7-14(19(13)31-3)20-24-27-28(2)26-20/h5-7,10-12H,4,8-9H2,1-3H3,(H,22,23,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399775 (US10323036, Compound XVI-6 | US10793574, Compound ...) Show SMILES CCn1cc(-c2cccc(-c3nnn(C)n3)c2OC)c2cc(NC(=O)C3CC3)ncc12 Show InChI InChI=1S/C22H23N7O2/c1-4-29-12-17(16-10-19(23-11-18(16)29)24-22(30)13-8-9-13)14-6-5-7-15(20(14)31-3)21-25-27-28(2)26-21/h5-7,10-13H,4,8-9H2,1-3H3,(H,23,24,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399583 (US10323036, Compound I-27 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Cl)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C16H15ClN8O2/c1-24-16(26)12-10(7-11(17)19-15(12)21-24)18-9-6-4-5-8(13(9)27-3)14-20-23-25(2)22-14/h4-7H,1-3H3,(H2,18,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399598 (US10323036, Compound I-42 | US10793574, Compound I...) Show SMILES COc1cc(Cl)ccc1Nc1cc(Nc2cc(C)ccn2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C20H19ClN6O2/c1-11-6-7-22-16(8-11)24-17-10-14(18-19(25-17)26-27(2)20(18)28)23-13-5-4-12(21)9-15(13)29-3/h4-10H,1-3H3,(H3,22,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399600 (US10323036, Compound I-44 | US10793574, Compound I...) Show SMILES COc1cc(CO)ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C19H21N5O4/c1-24-19(27)16-13(20-12-6-3-10(9-25)7-14(12)28-2)8-15(21-17(16)23-24)22-18(26)11-4-5-11/h3,6-8,11,25H,4-5,9H2,1-2H3,(H3,20,21,22,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399622 (US10323036, Compound I-66 | US10793574, Compound I...) Show SMILES CCNC(=O)c1cccc(Nc2cc(Nc3cccc(-c4nnn(C)n4)c3OC)c3c(n2)[nH]n(C)c3=O)n1 Show InChI InChI=1S/C24H25N11O3/c1-5-25-23(36)15-10-7-11-17(27-15)28-18-12-16(19-22(29-18)31-34(2)24(19)37)26-14-9-6-8-13(20(14)38-4)21-30-33-35(3)32-21/h6-12H,5H2,1-4H3,(H,25,36)(H3,26,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399627 (US10323036, Compound I-71 | US10793574, Compound I...) Show SMILES COc1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H26N6O5/c1-28-23(32)19-16(12-18(25-20(19)27-28)26-21(30)13-3-4-13)24-15-6-5-14(11-17(15)33-2)22(31)29-7-9-34-10-8-29/h5-6,11-13H,3-4,7-10H2,1-2H3,(H3,24,25,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399633 (US10323036, Compound I-77 | US10793574, Compound I...) Show SMILES COc1c(F)cccc1Nc1cc(Nc2ccc(cn2)N2CCCCC2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C24H26FN7O2/c1-31-24(33)21-18(27-17-8-6-7-16(25)22(17)34-2)13-20(29-23(21)30-31)28-19-10-9-15(14-26-19)32-11-4-3-5-12-32/h6-10,13-14H,3-5,11-12H2,1-2H3,(H3,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399671 (US10323036, Compound I-115 | US10793574, Compound ...) Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2ccc(cn2)N2CCOCC2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C23H24ClN7O3/c1-30-23(32)20-17(26-16-5-3-4-15(24)21(16)33-2)12-19(28-22(20)29-30)27-18-7-6-14(13-25-18)31-8-10-34-11-9-31/h3-7,12-13H,8-11H2,1-2H3,(H3,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399675 (US10323036, Compound I-119 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3cncc(n3)C#N)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C19H16N8O3S/c1-27-19(28)17-13(23-12-5-3-4-6-14(12)31(2,29)30)7-15(25-18(17)26-27)24-16-10-21-9-11(8-20)22-16/h3-7,9-10H,1-2H3,(H3,22,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399686 (US10323036, Compound I-130 | US10793574, Compound ...) Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2ccc(C(=O)N3CCOCC3)c(n2)C(F)(F)F)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C25H23ClF3N7O4/c1-35-24(38)19-16(30-15-5-3-4-14(26)20(15)39-2)12-18(33-22(19)34-35)31-17-7-6-13(21(32-17)25(27,28)29)23(37)36-8-10-40-11-9-36/h3-7,12H,8-11H2,1-2H3,(H3,30,31,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399688 (US10323036, Compound I-132 | US10793574, Compound ...) Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2ccc(C)c(n2)C#N)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C21H18ClN7O2/c1-11-7-8-16(25-15(11)10-23)26-17-9-14(18-20(27-17)28-29(2)21(18)30)24-13-6-4-5-12(22)19(13)31-3/h4-9H,1-3H3,(H3,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399693 (US10323036, Compound I-137 | US10793574, Compound ...) Show SMILES Cn1ccc(Nc2cc(Nc3ccccc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)n1 Show InChI InChI=1S/C18H19N7O3S/c1-24-9-8-14(22-24)20-15-10-12(16-17(21-15)23-25(2)18(16)26)19-11-6-4-5-7-13(11)29(3,27)28/h4-10H,1-3H3,(H3,19,20,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399697 (US10323036, Compound I-141 | US10793574, Compound ...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)ccc(C(=O)N2CCCC2)c1F Show InChI InChI=1S/C23H25FN6O4/c1-29-23(33)17-15(11-16(26-20(17)28-29)27-21(31)12-5-6-12)25-14-8-7-13(18(24)19(14)34-2)22(32)30-9-3-4-10-30/h7-8,11-12H,3-6,9-10H2,1-2H3,(H3,25,26,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399716 (US10323036, Compound I-199 | US10793574, Compound ...) Show SMILES Cc1cc(Nc2cc(Nc3ccc(Cl)cc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)nc(C)n1 Show InChI InChI=1S/C20H20ClN7O3S/c1-10-7-16(23-11(2)22-10)25-17-9-14(18-19(26-17)27-28(3)20(18)29)24-13-6-5-12(21)8-15(13)32(4,30)31/h5-9H,1-4H3,(H3,22,23,24,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399723 (US10323036, Compound I-210 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(NC(=O)[C@@H]3C[C@@H]3F)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399726 (US10323036, Compound I-213 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3ccc(cn3)C#N)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O Show InChI InChI=1S/C23H21N7O3S/c1-30-23(31)21-17(26-16-7-6-15(14-4-5-14)9-18(16)34(2,32)33)10-20(28-22(21)29-30)27-19-8-3-13(11-24)12-25-19/h3,6-10,12,14H,4-5H2,1-2H3,(H3,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399728 (US10323036, Compound I-215 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3cccc(n3)C(F)(F)F)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O Show InChI InChI=1S/C23H21F3N6O3S/c1-32-22(33)20-15(27-14-9-8-13(12-6-7-12)10-16(14)36(2,34)35)11-19(30-21(20)31-32)29-18-5-3-4-17(28-18)23(24,25)26/h3-5,8-12H,6-7H2,1-2H3,(H3,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399730 (US10323036, Compound I-217 | US10793574, Compound ...) Show SMILES CCc1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)c(c1)N(C)S(C)(=O)=O Show InChI InChI=1S/C21H26N6O4S/c1-5-12-6-9-14(16(10-12)27(3)32(4,30)31)22-15-11-17(24-20(28)13-7-8-13)23-19-18(15)21(29)26(2)25-19/h6,9-11,13H,5,7-8H2,1-4H3,(H3,22,23,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399731 (US10323036, Compound I-218 | US10793574, Compound ...) Show SMILES COCc1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)c(c1)N(C)S(C)(=O)=O Show InChI InChI=1S/C21H26N6O5S/c1-26-21(29)18-15(10-17(23-19(18)25-26)24-20(28)13-6-7-13)22-14-8-5-12(11-32-3)9-16(14)27(2)33(4,30)31/h5,8-10,13H,6-7,11H2,1-4H3,(H3,22,23,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399735 (US10323036, Compound I-222 | US10793574, Compound ...) Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2cc3CCCCn3n2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C21H22ClN7O2/c1-28-21(30)18-15(23-14-8-5-7-13(22)19(14)31-2)11-16(25-20(18)27-28)24-17-10-12-6-3-4-9-29(12)26-17/h5,7-8,10-11H,3-4,6,9H2,1-2H3,(H3,23,24,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399737 (US10323036, Compound I-225 | US10793574, Compound ...) Show SMILES CN(c1ccccc1Nc1cc(Nc2cnc3CCCc3n2)nc2[nH]n(C)c(=O)c12)S(C)(=O)=O Show InChI InChI=1S/C22H24N8O3S/c1-29-22(31)20-16(24-15-7-4-5-10-17(15)30(2)34(3,32)33)11-18(27-21(20)28-29)26-19-12-23-13-8-6-9-14(13)25-19/h4-5,7,10-12H,6,8-9H2,1-3H3,(H3,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399742 (US10323036, Compound I-230 | US10793574, Compound ...) Show SMILES CN(c1cc(F)c(F)cc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)S(C)(=O)=O Show InChI InChI=1S/C19H20F2N6O4S/c1-26-19(29)16-13(8-15(23-17(16)25-26)24-18(28)9-4-5-9)22-12-6-10(20)11(21)7-14(12)27(2)32(3,30)31/h6-9H,4-5H2,1-3H3,(H3,22,23,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399750 (US10323036, Compound I-239 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(NC(=O)C3CC3(F)F)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399758 (US10323036, Compound VIII-6 | US10793574, Compound...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2ncc(CO)s2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H23N7O3S/c1-30-12-26-21(29-30)15-4-3-5-17(20(15)33-2)27-18-8-19(28-22(32)13-6-7-13)24-10-16(18)23-25-9-14(11-31)34-23/h3-5,8-10,12-13,31H,6-7,11H2,1-2H3,(H2,24,27,28,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399614 (US10323036, Compound I-58 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)N3CCCC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C25H27N11O2/c1-34-25(37)21-18(27-17-8-6-7-16(22(17)38-3)23-30-33-35(2)32-23)13-20(29-24(21)31-34)28-19-10-9-15(14-26-19)36-11-4-5-12-36/h6-10,13-14H,4-5,11-12H2,1-3H3,(H3,26,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399620 (US10323036, Compound I-64 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cncc(n3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C21H18N12O2/c1-32-21(34)17-14(7-15(27-20(17)29-32)26-16-10-23-9-11(8-22)24-16)25-13-6-4-5-12(18(13)35-3)19-28-31-33(2)30-19/h4-7,9-10H,1-3H3,(H3,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399571 (US10323036, Compound I-14 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C21H22N8O3/c1-28-10-22-18(26-28)12-5-4-6-13(17(12)32-3)23-14-9-15(25-20(30)11-7-8-11)24-19-16(14)21(31)29(2)27-19/h4-6,9-11H,7-8H2,1-3H3,(H3,23,24,25,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399574 (US10323036, Compound I-17 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccccn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C22H21N9O2/c1-30-12-24-20(28-30)13-7-6-8-14(19(13)33-3)25-15-11-17(26-16-9-4-5-10-23-16)27-21-18(15)22(32)31(2)29-21/h4-12H,1-3H3,(H3,23,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399575 (US10323036, Compound I-18 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cc(C)ccn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H23N9O2/c1-13-8-9-24-17(10-13)27-18-11-16(19-22(28-18)30-32(3)23(19)33)26-15-7-5-6-14(20(15)34-4)21-25-12-31(2)29-21/h5-12H,1-4H3,(H3,24,26,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399579 (US10323036, Compound I-22 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cc(C)nc(C)n3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H24N10O2/c1-12-9-17(26-13(2)25-12)28-18-10-16(19-22(29-18)31-33(4)23(19)34)27-15-8-6-7-14(20(15)35-5)21-24-11-32(3)30-21/h6-11H,1-5H3,(H3,25,26,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6
					More data for this Ligand-Target Pair

<<  First   |  Previous   |  Displayed 51 to 100 (of 218 total )  |  Next  |  Last  >>

Jump to: