Found 12 hits of ki data for polymerid = 2814 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25266
(BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-...)Show SMILES OC(Cc1cccc(c1)-c1ccc(cc1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C20H20O7P2/c21-20(28(22,23)24,29(25,26)27)14-15-5-4-8-19(13-15)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-13,21H,14H2,(H2,22,23,24)(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25279
(BPH-608 | bisphosphonate, 31 | {1-hydroxy-2-[3-(3-...)Show SMILES OC(Cc1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C20H20O7P2/c21-20(28(22,23)24,29(25,26)27)14-15-6-4-9-17(12-15)19-11-5-10-18(13-19)16-7-2-1-3-8-16/h1-13,21H,14H2,(H2,22,23,24)(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25288
(BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...)Show SMILES OC(Cc1cccc(c1)-c1cccc2c1oc1ccccc21)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C20H18O8P2/c21-20(29(22,23)24,30(25,26)27)12-13-5-3-6-14(11-13)15-8-4-9-17-16-7-1-2-10-18(16)28-19(15)17/h1-11,21H,12H2,(H2,22,23,24)(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25289
(bisphosphonate, 38 | {1-hydroxy-2-[3-(3-phenylphen...)Show SMILES OC(COc1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C20H20O8P2/c21-20(29(22,23)24,30(25,26)27)14-28-19-11-5-10-18(13-19)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H2,22,23,24)(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25308
((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)Show InChI InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
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| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM12578
(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)Show InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14) | PDB
MMDB
Reactome pathway
KEGG
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| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description
Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104
BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50336506
(2-(decyl(methyl)amino)ethane-1,1-diyldiphosphonic ...)Show InChI InChI=1S/C13H31NO6P2/c1-3-4-5-6-7-8-9-10-11-14(2)12-13(21(15,16)17)22(18,19)20/h13H,3-12H2,1-2H3,(H2,15,16,17)(H2,18,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description
Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author
Article DOI: 10.1128/AAC.00198-10
BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25259
(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)Show SMILES CCCCCCCCCCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1 Show InChI InChI=1S/C17H31NO7P2/c1-2-3-4-5-6-7-8-9-13-25-16-11-10-12-18(14-16)15-17(26(19,20)21)27(22,23)24/h10-12,14,17H,2-9,13,15H2,1H3,(H3-,19,20,21,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description
Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author
Article DOI: 10.1128/AAC.00198-10
BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50336505
(2-(methyl(octyl)amino)ethane-1,1-diyldiphosphonic ...)Show InChI InChI=1S/C11H27NO6P2/c1-3-4-5-6-7-8-9-12(2)10-11(19(13,14)15)20(16,17)18/h11H,3-10H2,1-2H3,(H2,13,14,15)(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description
Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author
Article DOI: 10.1128/AAC.00198-10
BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM12576
(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)Show InChI InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15) | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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MCE
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PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 8.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology
Curated by ChEMBL
| Assay Description
Inhibition of human GGPPS |
Antimicrob Agents Chemother 54: 2987-93 (2010)
Checked by Author
Article DOI: 10.1128/AAC.00198-10
BindingDB Entry DOI: 10.7270/Q2PK0GF9 |
More data for this
Ligand-Target Pair | |
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