Compile Data Set for Download or QSAR

Found 167 hits of ec50 for UniProtKB: P13569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297409 (US10117858, Example 16 | US20240058315, Example 17) Show SMILES C[C@](O)(CNC(=O)c1nc(c(cc1N)C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C12H10F9N3O2/c1-9(26,12(19,20)21)3-23-8(25)6-5(22)2-4(10(13,14)15)7(24-6)11(16,17)18/h2,26H,3,22H2,1H3,(H,23,25)/t9-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297409 (US10117858, Example 16 | US20240058315, Example 17) Show SMILES C[C@](O)(CNC(=O)c1nc(c(cc1N)C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C12H10F9N3O2/c1-9(26,12(19,20)21)3-23-8(25)6-5(22)2-4(10(13,14)15)7(24-6)11(16,17)18/h2,26H,3,22H2,1H3,(H,23,25)/t9-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297396 (3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...) Show SMILES C[C@@](O)(CNC(=O)c1nc(Br)c(cc1N)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C11H10BrF6N3O2/c1-9(23,11(16,17)18)3-20-8(22)6-5(19)2-4(7(12)21-6)10(13,14)15/h2,23H,3,19H2,1H3,(H,20,22)/t9-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526477 (US11186566, Compound 16) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526476 (US11186566, Compound 15) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526467 (US11186566, Compound 4) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526510 (US11186566, Compound 49) Show SMILES COc1cccc(c1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526484 (US11186566, Compound 23) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526489 (US11186566, Compound 28) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(C)c2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526464 (US11186566, Compound 1 | US11186566, Compound 17) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526511 (US11186566, Compound 50) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2F)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526492 (US11186566, Compound 31) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(O)cc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297403 (3-Amino-6-methoxy-5-trifluoromethyl-pyridine-2-car...) Show SMILES COc1nc(C(=O)NCC(O)C(F)(F)F)c(N)cc1C(F)(F)F Show InChI InChI=1S/C11H11F6N3O3/c1-23-9-4(10(12,13)14)2-5(18)7(20-9)8(22)19-3-6(21)11(15,16)17/h2,6,21H,3,18H2,1H3,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297401 (3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...) Show SMILES CC(C)(O)CNC(=O)c1nc(-c2ccc(F)cc2)c(cc1N)C(F)(F)F Show InChI InChI=1S/C17H17F4N3O2/c1-16(2,26)8-23-15(25)14-12(22)7-11(17(19,20)21)13(24-14)9-3-5-10(18)6-4-9/h3-7,26H,8,22H2,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	37	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297406 (3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...) Show SMILES C[C@](O)(CNC(=O)c1nc(-c2ccc(F)cc2)c(cc1N)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C17H14F7N3O2/c1-15(29,17(22,23)24)7-26-14(28)13-11(25)6-10(16(19,20)21)12(27-13)8-2-4-9(18)5-3-8/h2-6,29H,7,25H2,1H3,(H,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526514 (US11186566, Compound 53) Show SMILES COc1ccccc1S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526475 (US11186566, Compound 14) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526493 (US11186566, Compound 32) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2nc(OCCC3(CC3)C(F)(F)F)cc2F)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526471 (US11186566, Compound 10) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CCC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526504 (US11186566, Compound 43) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2Cl)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526523 (US11186566, Compound 63 | US11186566, Compound 64) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3C4(CC4)C33CC3)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526519 (US11186566, Compound 58) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3(CCC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526468 (US11186566, Compound 5) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526516 (US11186566, Compound 55) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CC3)C(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526512 (US11186566, Compound 51) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526503 (US11186566, Compound 42) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC(C3CC3)C3CC3)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297402 (US10117858, Example 5 | US20240058315, Example 5) Show SMILES COc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F |r| Show InChI InChI=1S/C12H13F6N3O3/c1-10(23,12(16,17)18)4-20-8(22)7-6(19)3-5(11(13,14)15)9(21-7)24-2/h3,23H,4,19H2,1-2H3,(H,20,22)/t10-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297407 (5-Amino-6′-methyl-3-trifluoromethyl-[2,3R...) Show SMILES Cc1ccc(cn1)-c1nc(C(=O)NCC(C)(O)C(F)(F)F)c(N)cc1C(F)(F)F Show InChI InChI=1S/C17H16F6N4O2/c1-8-3-4-9(6-25-8)12-10(16(18,19)20)5-11(24)13(27-12)14(28)26-7-15(2,29)17(21,22)23/h3-6,29H,7,24H2,1-2H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	51	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297398 (3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...) Show SMILES C[C@](O)(CNC(=O)c1nc(Br)c(cc1N)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C11H10BrF6N3O2/c1-9(23,11(16,17)18)3-20-8(22)6-5(19)2-4(7(12)21-6)10(13,14)15/h2,23H,3,19H2,1H3,(H,20,22)/t9-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526526 (US11186566, Compound A) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccnc2N)-n2ccc(OCC(C)(C)C)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297408 (3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...) Show SMILES C[C@@](O)(CNC(=O)c1nc(-c2ccc(F)cc2)c(cc1N)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C17H14F7N3O2/c1-15(29,17(22,23)24)7-26-14(28)13-11(25)6-10(16(19,20)21)12(27-13)8-2-4-9(18)5-3-8/h2-6,29H,7,25H2,1H3,(H,26,28)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526500 (US11186566, Compound 39) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(O[C@H]3C[C@H]4CC[C@@H]3C4)n2)C(C)(C)C1 |r,THB:26:27:33:30.31| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526502 (US11186566, Compound 41) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC(C3CC3)C3CC3)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526485 (US11186566, Compound 24) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(C)cc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526498 (US11186566, Compound 37) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(COCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297400 (US10117858, Example 4 | US10117858, Example 6 | US...) Show SMILES COc1nc(C(=O)NCC(C)(O)C(F)(F)F)c(N)cc1C(F)(F)F Show InChI InChI=1S/C12H13F6N3O3/c1-10(23,12(16,17)18)4-20-8(22)7-6(19)3-5(11(13,14)15)9(21-7)24-2/h3,23H,4,19H2,1-2H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	76	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526501 (US11186566, Compound 40) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3C[C@@H]4CC[C@@H]3C4)n2)C(C)(C)C1 |r,THB:27:28:31.32:34| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526518 (US11186566, Compound 57) Show SMILES COc1ccc(c(C)c1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526494 (US11186566, Compound 33) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(O)cc2)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM297397 (US10117858, Example 10 | US10117858, Example 9 | U...) Show SMILES CC(O)(CNC(=O)c1nc(-c2ccc(Cl)cc2Cl)c(cc1N)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C17H13Cl2F6N3O2/c1-15(30,17(23,24)25)6-27-14(29)13-11(26)5-9(16(20,21)22)12(28-13)8-3-2-7(18)4-10(8)19/h2-5,30H,6,26H2,1H3,(H,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526491 (US11186566, Compound 30 | US11186566, Compound 36) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526464 (US11186566, Compound 1 | US11186566, Compound 17) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526466 ((S)—N-((4-Hydroxy-3-methoxyphenyl)sulfonyl)-6...) Show SMILES COc1cc(ccc1O)S(=O)(=O)NC(=O)c1ccc(nc1Cl)-n1ccc(OCCC2(CC2)C(F)(F)F)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526467 (US11186566, Compound 4) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526468 (US11186566, Compound 5) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526469 (US11186566, Compound 8) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3C4(CC4)C33CC3)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526471 (US11186566, Compound 10) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CCC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526473 (US11186566, Compound 12) Show SMILES COc1cc(C)ccc1S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526475 (US11186566, Compound 14) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM526476 (US11186566, Compound 15) Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA					Assay Description The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...				Citation and Details BindingDB Entry DOI: 10.7270/Q22R3VVH
					More data for this Ligand-Target Pair

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