Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM50505257 (CHEMBL4471012) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Binding affinity to human recombinant Nav1.1 by radioligand binding assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM76858 (US9546164, 580 | US9694002, 580) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Binding affinity to human recombinant Nav1.1 by radioligand binding assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM50521571 (CHEMBL4464990) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.1 expressed in CHO cells at -60 mV holding potential by manual patch clamp electrophysiology method | J Med Chem 62: 4091-4109 (2019) Article DOI: 10.1021/acs.jmedchem.9b00141 BindingDB Entry DOI: 10.7270/Q2B85CJ3 | |||||||||||
More data for this Ligand-Target Pair |