Compile Data Set for Download or QSAR

Found 11 hits of ec50 for UniProtKB: P04637   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463353 (CHEMBL4248974) Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C19H21N3O3S/c1-20-13-14-22(18-6-3-2-5-17(18)20)26(24,25)16-10-8-15(9-11-16)21-12-4-7-19(21)23/h2-3,5-6,8-11H,4,7,12-14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463352 (CHEMBL4238053) Show SMILES COc1ccc2N(CCN(C)c2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C20H23N3O4S/c1-21-12-13-23(18-10-7-16(27-2)14-19(18)21)28(25,26)17-8-5-15(6-9-17)22-11-3-4-20(22)24/h5-10,14H,3-4,11-13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463354 (CHEMBL4246320) Show SMILES Cc1ccc2N(CCCc2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C20H22N2O3S/c1-15-6-11-19-16(14-15)4-2-13-22(19)26(24,25)18-9-7-17(8-10-18)21-12-3-5-20(21)23/h6-11,14H,2-5,12-13H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463359 (CHEMBL4243509) Show SMILES COc1ccc2N(CCCc2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C20H22N2O4S/c1-26-17-8-11-19-15(14-17)4-2-13-22(19)27(24,25)18-9-6-16(7-10-18)21-12-3-5-20(21)23/h6-11,14H,2-5,12-13H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463351 (CHEMBL4240212) Show SMILES O=C1CCCN1c1ccc(cc1)S(=O)(=O)N1CCCc2ccccc12 Show InChI InChI=1S/C19H20N2O3S/c22-19-8-4-13-20(19)16-9-11-17(12-10-16)25(23,24)21-14-3-6-15-5-1-2-7-18(15)21/h1-2,5,7,9-12H,3-4,6,8,13-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463353 (CHEMBL4248974) Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C19H21N3O3S/c1-20-13-14-22(18-6-3-2-5-17(18)20)26(24,25)16-10-8-15(9-11-16)21-12-4-7-19(21)23/h2-3,5-6,8-11H,4,7,12-14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Activation of p53 in human MCF7 cell lysates assessed as increase in total p53 protein level by Western blot analysis				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463358 (CHEMBL4244338) Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCCC1 Show InChI InChI=1S/C19H23N3O2S/c1-20-14-15-22(19-7-3-2-6-18(19)20)25(23,24)17-10-8-16(9-11-17)21-12-4-5-13-21/h2-3,6-11H,4-5,12-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463356 (CHEMBL4240141) Show SMILES CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCC=N1 |c:26| Show InChI InChI=1S/C18H20N4O2S/c1-20-13-14-22(18-6-3-2-5-17(18)20)25(23,24)16-9-7-15(8-10-16)21-12-4-11-19-21/h2-3,5-11H,4,12-14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	74	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463355 (CHEMBL4240977) Show SMILES CC(C)(C)c1ccc2N(CCCc2c1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C23H28N2O3S/c1-23(2,3)18-8-13-21-17(16-18)6-4-15-25(21)29(27,28)20-11-9-19(10-12-20)24-14-5-7-22(24)26/h8-13,16H,4-7,14-15H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463357 (CHEMBL4243377) Show SMILES CCCN(c1ccccc1)S(=O)(=O)c1ccc(cc1)N1CCCC1=O Show InChI InChI=1S/C19H22N2O3S/c1-2-14-21(17-7-4-3-5-8-17)25(23,24)18-12-10-16(11-13-18)20-15-6-9-19(20)22/h3-5,7-8,10-13H,2,6,9,14-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Homo sapiens (Human))	BDBM50463350 (CHEMBL4243580) Show SMILES O=S(=O)(N1CCCc2ccccc12)c1ccc(cc1)-n1cncn1 Show InChI InChI=1S/C17H16N4O2S/c22-24(23,21-11-3-5-14-4-1-2-6-17(14)21)16-9-7-15(8-10-16)20-13-18-12-19-20/h1-2,4,6-10,12-13H,3,5,11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Induction of p53 transcriptional activity (unknown origin) expressed in HEK293 cells coexpressing TK-driven Rluc after 20 to 22 hrs by luciferase rep...				Bioorg Med Chem 26: 4441-4451 (2018) Article DOI: 10.1016/j.bmc.2018.07.042 BindingDB Entry DOI: 10.7270/Q2CN76JW
					More data for this Ligand-Target Pair