Found 8 hits of kd for UniProtKB: P97287 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM21447
(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)Show SMILES CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Binding affinity for GST-tagged mouse MCL1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem Lett 21: 4951-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.134
BindingDB Entry DOI: 10.7270/Q2DB8287 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM21400
(CHEMBL192571 | N-[(4-{[(2R)-4-(dimethylamino)-1-(p...)Show SMILES CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1 |r| Show InChI InChI=1S/C32H41N5O5S2/c1-32(2)17-20-36(21-18-32)26-12-10-24(11-13-26)31(38)34-44(41,42)28-14-15-29(30(22-28)37(39)40)33-25(16-19-35(3)4)23-43-27-8-6-5-7-9-27/h5-15,22,25,33H,16-21,23H2,1-4H3,(H,34,38)/t25-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Binding affinity for GST-tagged mouse MCL1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem Lett 21: 4951-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.134
BindingDB Entry DOI: 10.7270/Q2DB8287 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM50262597
(CHEMBL453437 | [(2S,3R,4S)-1-(Biphenyl-4-carbonyl)...)Show SMILES COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc(cc3)-c3ccccc3)c2c1)C(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C41H38N2O8/c1-49-22-23-50-26-51-33-20-21-35-34(24-33)38(42-40(47)31-16-12-29(13-17-31)27-8-4-2-5-9-27)39(46)36(25-37(44)45)43(35)41(48)32-18-14-30(15-19-32)28-10-6-3-7-11-28/h2-21,24,36,38-39,46H,22-23,25-26H2,1H3,(H,42,47)(H,44,45)/t36-,38-,39-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem 16: 7443-9 (2008)
Article DOI: 10.1016/j.bmc.2008.06.023
BindingDB Entry DOI: 10.7270/Q29023K1 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM50262594
((2S,3R,4S)-4-[(Biphenyl-4-carbonyl)-amino]-2-carbo...)Show SMILES COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc(cc3)-c3ccccc3)c2c1)C(=O)OCC[Si](C)(C)C |r| Show InChI InChI=1S/C34H42N2O9Si/c1-42-16-17-43-22-45-26-14-15-28-27(20-26)31(35-33(40)25-12-10-24(11-13-25)23-8-6-5-7-9-23)32(39)29(21-30(37)38)36(28)34(41)44-18-19-46(2,3)4/h5-15,20,29,31-32,39H,16-19,21-22H2,1-4H3,(H,35,40)(H,37,38)/t29-,31-,32-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem 16: 7443-9 (2008)
Article DOI: 10.1016/j.bmc.2008.06.023
BindingDB Entry DOI: 10.7270/Q29023K1 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM50262593
(2-((2S,3R,4S)-4-(2-naphthamido)-3-hydroxy-6-((2-me...)Show SMILES COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc4ccccc4c3)c2c1)C(=O)OCC[Si](C)(C)C |r| Show InChI InChI=1S/C32H40N2O9Si/c1-40-13-14-41-20-43-24-11-12-26-25(18-24)29(33-31(38)23-10-9-21-7-5-6-8-22(21)17-23)30(37)27(19-28(35)36)34(26)32(39)42-15-16-44(2,3)4/h5-12,17-18,27,29-30,37H,13-16,19-20H2,1-4H3,(H,33,38)(H,35,36)/t27-,29-,30-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem 16: 7443-9 (2008)
Article DOI: 10.1016/j.bmc.2008.06.023
BindingDB Entry DOI: 10.7270/Q29023K1 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM50262591
(CHEMBL459561 | [(2S,3R,4S)-4-Allyloxycarbonylamino...)Show SMILES COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)OCC=C)c2c1)C(=O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C32H34N2O9/c1-3-15-42-32(39)33-29-25-18-24(43-20-41-17-16-40-2)13-14-26(25)34(27(30(29)37)19-28(35)36)31(38)23-11-9-22(10-12-23)21-7-5-4-6-8-21/h3-14,18,27,29-30,37H,1,15-17,19-20H2,2H3,(H,33,39)(H,35,36)/t27-,29-,30-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem 16: 7443-9 (2008)
Article DOI: 10.1016/j.bmc.2008.06.023
BindingDB Entry DOI: 10.7270/Q29023K1 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM50262596
(2-((2S,3R,4S)-4-(2-naphthamido)-1-(2-naphthoyl)-3-...)Show SMILES COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc4ccccc4c3)c2c1)C(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C37H34N2O8/c1-45-16-17-46-22-47-29-14-15-31-30(20-29)34(38-36(43)27-12-10-23-6-2-4-8-25(23)18-27)35(42)32(21-33(40)41)39(31)37(44)28-13-11-24-7-3-5-9-26(24)19-28/h2-15,18-20,32,34-35,42H,16-17,21-22H2,1H3,(H,38,43)(H,40,41)/t32-,34-,35-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem 16: 7443-9 (2008)
Article DOI: 10.1016/j.bmc.2008.06.023
BindingDB Entry DOI: 10.7270/Q29023K1 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
(Mus musculus (Mouse)) | BDBM50262590
(2-((2S,3R,4S)-1-(2-naphthoyl)-4-(allyloxycarbonyl)...)Show SMILES COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)OCC=C)c2c1)C(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C30H32N2O9/c1-3-12-40-30(37)31-27-23-16-22(41-18-39-14-13-38-2)10-11-24(23)32(25(28(27)35)17-26(33)34)29(36)21-9-8-19-6-4-5-7-20(19)15-21/h3-11,15-16,25,27-28,35H,1,12-14,17-18H2,2H3,(H,31,37)(H,33,34)/t25-,27-,28-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells |
Bioorg Med Chem 16: 7443-9 (2008)
Article DOI: 10.1016/j.bmc.2008.06.023
BindingDB Entry DOI: 10.7270/Q29023K1 |
More data for this
Ligand-Target Pair | |
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