BindingDB PrimarySearch

Found 10 hits of kd for UniProtKB: P06935
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33253 (phthalazine-based compound, 4) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	4.60E+3	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33255 (phthalazine-based compound, 6) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	7.00E+3	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33254 (phthalazine-based compound, 5) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	1.00E+5	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33252 (phthalazine-based compound, 3) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	9.00E+4	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33250 (phthalazine-based compound, 1) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+4	2.10E+4	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein (West Nile virus)	BDBM50468907 (CHEMBL549740) Show SMILES Cc1cc(CSC(N)=N)c(C)cc1CSC(N)=N Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Charles University Prague Curated by ChEMBL					Assay Description Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans				Bioorg Med Chem 18: 1434-40 (2010) Article DOI: 10.1016/j.bmc.2010.01.015
Charles University Prague Curated by ChEMBL					More data for this Ligand-Target Pair
Genome polyprotein [1517-1688]/Mastoparan-2 [1420-1466] (West Nile virus (WNV))	BDBM33247 (benzenecarboximidamide, 1) Show SMILES NC(=N)c1cccc(NC(=O)Nc2cccc(c2)C(N)=N)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.50E+4	n/a	n/a	n/a	7.5	25
University of Zurich					Assay Description Binding was also measured by a competition assay with a noncovalently bound inhibitor (Kd=4.6 uM) that quenched tryptophan fluorescence upon binding ...				J Med Chem 52: 4860-8 (2009) Article DOI: 10.1021/jm900448m BindingDB Entry DOI: 10.7270/Q20C4T4N
University of Zurich					More data for this Ligand-Target Pair
Genome polyprotein [1517-1688]/Mastoparan-2 [1420-1466] (West Nile virus (WNV))	BDBM33249 (4-nitrophenyl 4-carbamimidamidobenzoate, 2) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.60E+4	n/a	n/a	n/a	7.5	25
University of Zurich					Assay Description Binding was also measured by a competition assay with a noncovalently bound inhibitor (Kd=4.6 uM) that quenched tryptophan fluorescence upon binding ...				J Med Chem 52: 4860-8 (2009) Article DOI: 10.1021/jm900448m BindingDB Entry DOI: 10.7270/Q20C4T4N
University of Zurich					More data for this Ligand-Target Pair
Genome polyprotein (West Nile virus)	BDBM50468907 (CHEMBL549740) Show SMILES Cc1cc(CSC(N)=N)c(C)cc1CSC(N)=N Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Binding affinity to West Nile virus NS3 protease by 15N-HSQC 1H NMR analysis				Eur J Med Chem 156: 907-917 (2018) Article DOI: 10.1016/j.ejmech.2018.07.042 BindingDB Entry DOI: 10.7270/Q26W9DRP
University of Z£rich Curated by ChEMBL					More data for this Ligand-Target Pair
Genome polyprotein (West Nile virus)	BDBM50542238 (CHEMBL4640778) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
Australian National University Curated by ChEMBL					Assay Description Binding affinity to West Nile virus NS2B-NS3 protease				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126965 BindingDB Entry DOI: 10.7270/Q27M0CGT
Australian National University Curated by ChEMBL					More data for this Ligand-Target Pair