Compile Data Set for Download or QSAR

Found 1 hit of kd for UniProtKB: P14735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-degrading enzyme (Homo sapiens (Human))	BDBM50459189 (CHEMBL4211248) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)NCC(=O)N2CCC[C@@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C88H124N22O23S/c1-45(2)34-58(79(125)103-61(37-50-23-25-52(112)26-24-50)80(126)100-59(35-46(3)4)83(129)108-73(47(5)6)86(132)107-65(44-134)75(121)95-42-68(89)113)101-84(130)64-41-94-69(114)39-63(74(120)96-43-70(115)109-32-15-22-67(109)87(133)110-33-14-21-66(110)85(131)99-57(78(124)106-64)28-30-72(118)119)105-81(127)60(36-49-16-9-8-10-17-49)102-76(122)55(20-13-31-92-88(90)91)98-82(128)62(38-51-40-93-54-19-12-11-18-53(51)54)104-77(123)56(97-48(7)111)27-29-71(116)117/h8-12,16-19,23-26,40,45-47,55-67,73,93,112,134H,13-15,20-22,27-39,41-44H2,1-7H3,(H2,89,113)(H,94,114)(H,95,121)(H,96,120)(H,97,111)(H,98,128)(H,99,131)(H,100,126)(H,101,130)(H,102,122)(H,103,125)(H,104,123)(H,105,127)(H,106,124)(H,107,132)(H,108,129)(H,116,117)(H,118,119)(H4,90,91,92)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67+,73-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Peking University Shenzhen Graduate School Curated by ChEMBL					Assay Description Binding affinity to IDE E111Q mutant (unknown origin) using N-terminal FITC-labeled compound after 2 hrs in absence of light at 298 K by fluorescence...				J Med Chem 61: 8174-8185 (2018) Article DOI: 10.1021/acs.jmedchem.8b00418 BindingDB Entry DOI: 10.7270/Q22N54XF
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