Compile Data Set for Download or QSAR

Found 7 hits of ec50 for UniProtKB: P28565   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039564 (CHEMBL83597 | [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...) Show SMILES CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12 Show InChI InChI=1S/C19H21N5O2/c1-23-9-3-4-15(23)10-13-12-21-17-7-6-14(11-16(13)17)22-19-18(24(25)26)5-2-8-20-19/h2,5-8,11-12,15,21H,3-4,9-10H2,1H3,(H,20,22)/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039566 ((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...) Show SMILES [O-][N+](=O)c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 Show InChI InChI=1S/C18H19N5O2/c24-23(25)17-4-2-8-20-18(17)22-14-5-6-16-15(10-14)12(11-21-16)9-13-3-1-7-19-13/h2,4-6,8,10-11,13,19,21H,1,3,7,9H2,(H,20,22)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039567 (CHEMBL84942 | [3-(1-Methyl-pyrrolidin-3-yl)-1H-ind...) Show SMILES CN1CCC(C1)c1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12 Show InChI InChI=1S/C18H19N5O2/c1-22-8-6-12(11-22)15-10-20-16-5-4-13(9-14(15)16)21-18-17(23(24)25)3-2-7-19-18/h2-5,7,9-10,12,20H,6,8,11H2,1H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039565 (CHEMBL314213 | [3-(2-Dimethylamino-ethyl)-1H-indol...) Show SMILES CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12 Show InChI InChI=1S/C17H19N5O2/c1-21(2)9-7-12-11-19-15-6-5-13(10-14(12)15)20-17-16(22(23)24)4-3-8-18-17/h3-6,8,10-11,19H,7,9H2,1-2H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate | 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 1D (RAT)	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM84737 (3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1,4-dihydro-py...) Show SMILES O=c1ccc2[nH]cc(C3=CCNCC3)c2[nH]1 |t:8| Show InChI InChI=1S/C12H11N3O/c16-11-2-1-10-12(15-11)9(7-14-10)8-3-5-13-6-4-8/h1-3,7,13H,4-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of rat substantia nigra				J Med Chem 33: 2087-93 (1990) BindingDB Entry DOI: 10.7270/Q2GQ6WR3
					More data for this Ligand-Target Pair