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Compile Data Set for Download or QSAR

Found 197 hits of ic50 for UniProtKB: P20288   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(BOVINE)		BDBM50064578
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-5-4-6-17-9-10-18-21(16-17)28-22(26)23-18/h2-3,7-10,16H,4-6,11-15H2,1H3,(H,23,26)
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n/an/a 0.770n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 1.20n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036855
PNG
(2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H36N2O3/c1-3-12-25(19-15-21-22(28-2)10-7-11-23(21)29-17-19)13-4-5-14-26-16-18-8-6-9-20(18)24(26)27/h7,10-11,18-20H,3-6,8-9,12-17H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064576
PNG
(7-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3N(C)C(=O)COc3c2)CC1
Show InChI InChI=1S/C22H27N3O3/c1-23-18-8-7-17(15-21(18)28-16-22(23)26)9-10-24-11-13-25(14-12-24)19-5-3-4-6-20(19)27-2/h3-8,15H,9-14,16H2,1-2H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036851
PNG
(8-[4-(Chroman-3-yl-propyl-amino)-butyl]-8-aza-spir...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1
Show InChI InChI=1S/C25H36N2O3/c1-2-13-26(21-16-20-9-3-4-10-22(20)30-19-21)14-7-8-15-27-23(28)17-25(18-24(27)29)11-5-6-12-25/h3-4,9-10,21H,2,5-8,11-19H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064577
PNG
(7-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3N(C)C(=O)COc3c2)CC1
Show InChI InChI=1S/C24H31N3O3/c1-25-20-11-10-19(17-23(20)30-18-24(25)28)7-5-6-12-26-13-15-27(16-14-26)21-8-3-4-9-22(21)29-2/h3-4,8-11,17H,5-7,12-16,18H2,1-2H3
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n/an/a 5.20n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064580
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-26-19-7-3-2-6-18(19)24-13-11-23(12-14-24)10-4-5-16-8-9-17-20(15-16)27-21(25)22-17/h2-3,6-9,15H,4-5,10-14H2,1H3,(H,22,25)
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n/an/a 6n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036874
PNG
(4-Fluoro-N-{4-[(5-methoxy-chroman-3-yl)-propyl-ami...)
Show SMILES CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H31FN2O3/c1-3-14-27(20-16-21-22(29-2)7-6-8-23(21)30-17-20)15-5-4-13-26-24(28)18-9-11-19(25)12-10-18/h6-12,20H,3-5,13-17H2,1-2H3,(H,26,28)
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n/an/a 7n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036850
PNG
(8-{4-[(5-Hydroxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1
Show InChI InChI=1S/C25H36N2O4/c1-2-12-26(19-15-20-21(28)8-7-9-22(20)31-18-19)13-5-6-14-27-23(29)16-25(17-24(27)30)10-3-4-11-25/h7-9,19,28H,2-6,10-18H2,1H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064584
PNG
(4-Methyl-7-{4-[4-(3-trifluoromethyl-phenyl)-pipera...)
Show SMILES CN1C(=O)COc2cc(CCCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)ccc12
Show InChI InChI=1S/C24H28F3N3O2/c1-28-21-9-8-18(15-22(21)32-17-23(28)31)5-2-3-10-29-11-13-30(14-12-29)20-7-4-6-19(16-20)24(25,26)27/h4,6-9,15-16H,2-3,5,10-14,17H2,1H3
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n/an/a 8n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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n/an/a 10n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036857
PNG
(2-Methoxy-N-{4-[(5-methoxy-chroman-3-yl)-propyl-am...)
Show SMILES CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C25H34N2O4/c1-4-15-27(19-17-21-23(30-3)12-9-13-24(21)31-18-19)16-8-7-14-26-25(28)20-10-5-6-11-22(20)29-2/h5-6,9-13,19H,4,7-8,14-18H2,1-3H3,(H,26,28)
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036865
PNG
(8-{3-[(5-Methoxy-chroman-3-yl)-propyl-amino]-propo...)
Show SMILES CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C25H36N2O5/c1-3-12-26(19-15-20-21(30-2)8-6-9-22(20)31-18-19)13-7-14-32-27-23(28)16-25(17-24(27)29)10-4-5-11-25/h6,8-9,19H,3-5,7,10-18H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036846
PNG
((5-Methoxy-chroman-3-yl)-(4-piperidin-1-yl-butyl)-...)
Show SMILES CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C22H36N2O2/c1-3-12-24(16-8-7-15-23-13-5-4-6-14-23)19-17-20-21(25-2)10-9-11-22(20)26-18-19/h9-11,19H,3-8,12-18H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50017536
PNG
((Flumezapine)7-Fluoro-2-methyl-10-(4-methyl-pipera...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2sc(C)cc12 |t:8|
Show InChI InChI=1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,20H,5-8H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against dopamine receptor D2 in calf caudate tissue using [3H]spiperone

J Med Chem 32: 2375-81 (1989)


BindingDB Entry DOI: 10.7270/Q2FN16RX
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM82368
PNG
(CAS_121851 | CHEMBL11592 | CHEMBL301060 | NSC_1218...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3
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Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064585
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Oc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C19H21N3O2S/c23-17-4-2-1-3-16(17)22-11-9-21(10-12-22)8-7-14-5-6-15-18(13-14)25-19(24)20-15/h1-6,13,23H,7-12H2,(H,20,24)
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n/an/a 27n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 30n/an/an/an/an/an/a



Lilly Research Centre Ltd.

Curated by ChEMBL


Assay Description
Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes.

J Med Chem 36: 912-8 (1993)


BindingDB Entry DOI: 10.7270/Q2FJ2FT2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036858
PNG
((5-Methoxy-chroman-3-yl)-(4-morpholin-4-yl-butyl)-...)
Show SMILES CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C21H34N2O3/c1-3-9-23(11-5-4-10-22-12-14-25-15-13-22)18-16-19-20(24-2)7-6-8-21(19)26-17-18/h6-8,18H,3-5,9-17H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036847
PNG
(CHEMBL54266 | N-{3-[(5-Methoxy-chroman-3-yl)-propy...)
Show SMILES CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C23H32N2O4S/c1-4-14-25(19-16-21-22(28-3)7-5-8-23(21)29-17-19)15-6-13-24-30(26,27)20-11-9-18(2)10-12-20/h5,7-12,19,24H,4,6,13-17H2,1-3H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036844
PNG
(2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C25H30N2O4/c1-3-13-26(18-16-21-22(30-2)11-8-12-23(21)31-17-18)14-6-7-15-27-24(28)19-9-4-5-10-20(19)25(27)29/h4-5,8-12,18H,3,6-7,13-17H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036849
PNG
(1-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H36N2O4/c1-5-11-25(18-14-19-20(29-4)9-8-10-21(19)30-17-18)12-6-7-13-26-22(27)15-24(2,3)16-23(26)28/h8-10,18H,5-7,11-17H2,1-4H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50017543
PNG
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)
Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r|
Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibitory activity against Dopamine receptor D2 in calf corpus striatum using [3H]-Spiperone as radioligand

J Med Chem 32: 2388-96 (1989)


BindingDB Entry DOI: 10.7270/Q2445KGF
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50020682
PNG
(7-(2-Dipropylamino-ethyl)-4-hydroxy-3H-benzothiazo...)
Show SMILES CCCN(CCC)CCc1ccc(O)c2[nH]c(=O)sc12
Show InChI InChI=1S/C15H22N2O2S/c1-3-8-17(9-4-2)10-7-11-5-6-12(18)13-14(11)20-15(19)16-13/h5-6,18H,3-4,7-10H2,1-2H3,(H,16,19)
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n/an/a 49n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiroperidol from homogenized bovine pituitary Dopamine receptor D2

J Med Chem 30: 1166-76 (1987)


BindingDB Entry DOI: 10.7270/Q2028QJ6
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036862
PNG
((5-Methoxy-chroman-3-yl)-dipropyl-amine | CHEMBL28...)
Show SMILES CCCN(CCC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
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n/an/a 50n/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.

J Med Chem 39: 4285-98 (1996)


Article DOI: 10.1021/jm950861w
BindingDB Entry DOI: 10.7270/Q2XP741N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064581
PNG
(3-Methyl-6-{4-[4-(3-trifluoromethyl-phenyl)-pipera...)
Show SMILES Cn1c2ccc(CCCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)cc2sc1=O
Show InChI InChI=1S/C23H26F3N3OS/c1-27-20-9-8-17(15-21(20)31-22(27)30)5-2-3-10-28-11-13-29(14-12-28)19-7-4-6-18(16-19)23(24,25)26/h4,6-9,15-16H,2-3,5,10-14H2,1H3
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n/an/a 50n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064590
PNG
(6-{4-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H24F3N3OS/c23-22(24,25)17-5-3-6-18(15-17)28-12-10-27(11-13-28)9-2-1-4-16-7-8-19-20(14-16)30-21(29)26-19/h3,5-8,14-15H,1-2,4,9-13H2,(H,26,29)
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n/an/a 57n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036859
PNG
(CHEMBL300735 | N-{4-[(5-Methoxy-chroman-3-yl)-prop...)
Show SMILES CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H34N2O4S/c1-4-15-26(20-17-22-23(29-3)8-7-9-24(22)30-18-20)16-6-5-14-25-31(27,28)21-12-10-19(2)11-13-21/h7-13,20,25H,4-6,14-18H2,1-3H3
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n/an/a 60n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064573
PNG
(6-{2-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H20F3N3OS/c21-20(22,23)15-2-1-3-16(13-15)26-10-8-25(9-11-26)7-6-14-4-5-17-18(12-14)28-19(27)24-17/h1-5,12-13H,6-11H2,(H,24,27)
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n/an/a 60n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036860
PNG
(CHEMBL25984 | Chroman-3-yl-dipropyl-amine)
Show SMILES CCCN(CCC)C1COc2ccccc2C1
Show InChI InChI=1S/C15H23NO/c1-3-9-16(10-4-2)14-11-13-7-5-6-8-15(13)17-12-14/h5-8,14H,3-4,9-12H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50017524
PNG
(7-Chloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCn1nc2Nc3ccc(Cl)cc3N=C(N3CCN(C)CC3)c2n1 |t:14|
Show InChI InChI=1S/C16H20ClN7/c1-3-24-20-14-15(21-24)18-12-5-4-11(17)10-13(12)19-16(14)23-8-6-22(2)7-9-23/h4-5,10H,3,6-9H2,1-2H3,(H,18,21)
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n/an/a 67n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against dopamine receptor D2 in calf caudate tissue using [3H]spiperone

J Med Chem 32: 2375-81 (1989)


BindingDB Entry DOI: 10.7270/Q2FN16RX
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064582
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3O)cc2sc1=O
Show InChI InChI=1S/C20H23N3O2S/c1-21-17-7-6-15(14-19(17)26-20(21)25)8-9-22-10-12-23(13-11-22)16-4-2-3-5-18(16)24/h2-7,14,24H,8-13H2,1H3
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n/an/a 71n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50024703
PNG
(6-[(2-Chloro-ethyl)-propyl-amino]-5,6,7,8-tetrahyd...)
Show SMILES CCCN(CCCl)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C15H22ClNO2/c1-2-6-17(7-5-16)13-4-3-11-9-14(18)15(19)10-12(11)8-13/h9-10,13,18-19H,2-8H2,1H3
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n/an/a 76n/an/an/an/an/an/a



Queen's Medical Centre

Curated by ChEMBL


Assay Description
Inhibition of purified human kidney renin, fluorometric assay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentration

J Med Chem 30: 1879-87 (1987)


BindingDB Entry DOI: 10.7270/Q2J103R1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036861
PNG
(2-{3-[(5-Methoxy-chroman-3-yl)-propyl-amino]-propy...)
Show SMILES CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H28N2O4/c1-3-12-25(17-15-20-21(29-2)10-6-11-22(20)30-16-17)13-7-14-26-23(27)18-8-4-5-9-19(18)24(26)28/h4-6,8-11,17H,3,7,12-16H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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Lilly Research Centre Ltd.

Curated by ChEMBL


Assay Description
Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes.

J Med Chem 36: 912-8 (1993)


BindingDB Entry DOI: 10.7270/Q2FJ2FT2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036868
PNG
(2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H30N2O5S/c1-3-13-25(18-16-20-21(30-2)10-8-11-22(20)31-17-18)14-6-7-15-26-24(27)19-9-4-5-12-23(19)32(26,28)29/h4-5,8-12,18H,3,6-7,13-17H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50064575
PNG
(6-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-3H-benzothia...)
Show SMILES O=c1[nH]c2ccc(CCN3CCN(CC3)c3ccccc3)cc2s1
Show InChI InChI=1S/C19H21N3OS/c23-19-20-17-7-6-15(14-18(17)24-19)8-9-21-10-12-22(13-11-21)16-4-2-1-3-5-16/h1-7,14H,8-13H2,(H,20,23)
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036853
PNG
((2,3-Dihydro-1H-benzo[f]chromen-2-yl)-dipropyl-ami...)
Show SMILES CCCN(CCC)C1COc2ccc3ccccc3c2C1
Show InChI InChI=1S/C19H25NO/c1-3-11-20(12-4-2)16-13-18-17-8-6-5-7-15(17)9-10-19(18)21-14-16/h5-10,16H,3-4,11-14H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036852
PNG
(2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H34N2O4/c1-3-12-25(17-15-20-21(29-2)10-7-11-22(20)30-16-17)13-4-5-14-26-23(27)18-8-6-9-19(18)24(26)28/h7,10-11,17-19H,3-6,8-9,12-16H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036859
PNG
(CHEMBL300735 | N-{4-[(5-Methoxy-chroman-3-yl)-prop...)
Show SMILES CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H34N2O4S/c1-4-15-26(20-17-22-23(29-3)8-7-9-24(22)30-18-20)16-6-5-14-25-31(27,28)21-12-10-19(2)11-13-21/h7-13,20,25H,4-6,14-18H2,1-3H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036866
PNG
(3-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCn1c2ncccc2oc1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C23H29N3O4/c1-3-12-25(17-15-18-19(28-2)8-6-9-20(18)29-16-17)13-4-5-14-26-22-21(30-23(26)27)10-7-11-24-22/h6-11,17H,3-5,12-16H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036852
PNG
(2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl...)
Show SMILES CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C24H34N2O4/c1-3-12-25(17-15-20-21(29-2)10-7-11-22(20)30-16-17)13-4-5-14-26-23(27)18-8-6-9-19(18)24(26)28/h7,10-11,17-19H,3-6,8-9,12-16H2,1-2H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50036862
PNG
((5-Methoxy-chroman-3-yl)-dipropyl-amine | CHEMBL28...)
Show SMILES CCCN(CCC)C1COc2cccc(OC)c2C1
Show InChI InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
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Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in calf caudate nucleus

J Med Chem 37: 1779-93 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6KPQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride

J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
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