Compile Data Set for Download or QSAR

Found 311 hits of ic50 for UniProtKB: P43005   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410463 (CHEMBL2113115) Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(F)ccc-23)c1)C(O)=O |r| Show InChI InChI=1S/C17H15FN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366609 (CHEMBL4177507) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(=O)Nc1ccc-2c(Cc3ccccc-23)c1)C(O)=O |r| Show InChI InChI=1S/C24H22N2O4/c25-21(24(28)29)22(30-14-15-6-2-1-3-7-15)23(27)26-18-10-11-20-17(13-18)12-16-8-4-5-9-19(16)20/h1-11,13,21-22H,12,14,25H2,(H,26,27)(H,28,29)/t21-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366609 (CHEMBL4177507) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(=O)Nc1ccc-2c(Cc3ccccc-23)c1)C(O)=O |r| Show InChI InChI=1S/C24H22N2O4/c25-21(24(28)29)22(30-14-15-6-2-1-3-7-15)23(27)26-18-10-11-20-17(13-18)12-16-8-4-5-9-19(16)20/h1-11,13,21-22H,12,14,25H2,(H,26,27)(H,28,29)/t21-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366614 (CHEMBL4176482) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O |r| Show InChI InChI=1S/C23H19BrF2N2O5/c24-16-10-17(25)18(26)11-19(16)33-15-8-6-14(7-9-15)28-22(29)21(20(27)23(30)31)32-12-13-4-2-1-3-5-13/h1-11,20-21H,12,27H2,(H,28,29)(H,30,31)/t20-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366614 (CHEMBL4176482) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O |r| Show InChI InChI=1S/C23H19BrF2N2O5/c24-16-10-17(25)18(26)11-19(16)33-15-8-6-14(7-9-15)28-22(29)21(20(27)23(30)31)32-12-13-4-2-1-3-5-13/h1-11,20-21H,12,27H2,(H,28,29)(H,30,31)/t20-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366616 (CHEMBL4176427) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)CCc2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C21H21F3N2O6/c22-21(23,24)14-7-4-12(5-8-14)6-9-16(27)26-15-3-1-2-13(10-15)11-32-18(20(30)31)17(25)19(28)29/h1-5,7-8,10,17-18H,6,9,11,25H2,(H,26,27)(H,28,29)(H,30,31)/t17-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366616 (CHEMBL4176427) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)CCc2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C21H21F3N2O6/c22-21(23,24)14-7-4-12(5-8-14)6-9-16(27)26-15-3-1-2-13(10-15)11-32-18(20(30)31)17(25)19(28)29/h1-5,7-8,10,17-18H,6,9,11,25H2,(H,26,27)(H,28,29)(H,30,31)/t17-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50327884 ((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50327884 ((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366626 (CHEMBL4165811) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)Cc2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C20H19F3N2O6/c21-20(22,23)13-6-4-11(5-7-13)9-15(26)25-14-3-1-2-12(8-14)10-31-17(19(29)30)16(24)18(27)28/h1-8,16-17H,9-10,24H2,(H,25,26)(H,27,28)(H,29,30)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366626 (CHEMBL4165811) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)Cc2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C20H19F3N2O6/c21-20(22,23)13-6-4-11(5-7-13)9-15(26)25-14-3-1-2-12(8-14)10-31-17(19(29)30)16(24)18(27)28/h1-8,16-17H,9-10,24H2,(H,25,26)(H,27,28)(H,29,30)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410457 (CHEMBL2113112) Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H17F3N2O3/c1-10-7-13(23-16(24)9-15(22)17(25)26)5-6-14(10)11-3-2-4-12(8-11)18(19,20)21/h2-8,15H,9,22H2,1H3,(H,23,24)(H,25,26)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410455 (CHEMBL2113116) Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(Cl)ccc-23)c1)C(O)=O |r| Show InChI InChI=1S/C17H15ClN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366648 (CHEMBL4173045) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-5-2-4-11(8-12)16(25)24-13-6-1-3-10(7-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366648 (CHEMBL4173045) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-5-2-4-11(8-12)16(25)24-13-6-1-3-10(7-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50327884 ((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting				J Med Chem 53: 7236-50 (2010) Article DOI: 10.1021/jm100959g BindingDB Entry DOI: 10.7270/Q27081NR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410464 (CHEMBL2113111) Show SMILES CCc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C18H18ClFN2O3/c1-2-10-7-11(12-3-5-14(20)13(19)8-12)4-6-16(10)22-17(23)9-15(21)18(24)25/h3-8,15H,2,9,21H2,1H3,(H,22,23)(H,24,25)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50327884 ((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of EAAT3 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assay				J Med Chem 63: 3834-3867 (2020) Article DOI: 10.1021/acs.jmedchem.9b01237 BindingDB Entry DOI: 10.7270/Q26113PD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410451 (CHEMBL1628570) Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1)C(O)=O |r| Show InChI InChI=1S/C17H16N2O3/c18-15(17(21)22)9-16(20)19-12-5-6-14-11(8-12)7-10-3-1-2-4-13(10)14/h1-6,8,15H,7,9,18H2,(H,19,20)(H,21,22)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410450 (CHEMBL2113118) Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3c-2cc(Cl)cc3Cl)c1)C(O)=O |r| Show InChI InChI=1S/C17H14Cl2N2O3/c18-9-5-12-11-2-1-10(21-16(22)7-15(20)17(23)24)3-8(11)4-13(12)14(19)6-9/h1-3,5-6,15H,4,7,20H2,(H,21,22)(H,23,24)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410456 (CHEMBL2113122) Show SMILES N[C@@H](CC(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F)C(O)=O |r| Show InChI InChI=1S/C17H15F3N2O3/c18-17(19,20)12-3-1-2-11(8-12)10-4-6-13(7-5-10)22-15(23)9-14(21)16(24)25/h1-8,14H,9,21H2,(H,22,23)(H,24,25)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366656 (CHEMBL4162363) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)13-7-2-1-6-12(13)16(25)24-11-5-3-4-10(8-11)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366656 (CHEMBL4162363) Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)13-7-2-1-6-12(13)16(25)24-11-5-3-4-10(8-11)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50173936 (2-Amino-N-(3-methyl-biphenyl-4-yl)-succinamic acid...) Show SMILES Cc1cc(ccc1NC(=O)CC(N)C(O)=O)-c1ccccc1 Show InChI InChI=1S/C17H18N2O3/c1-11-9-13(12-5-3-2-4-6-12)7-8-15(11)19-16(20)10-14(18)17(21)22/h2-9,14H,10,18H2,1H3,(H,19,20)(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410465 (CHEMBL2113113) Show SMILES N[C@@H](CC(=O)Nc1ccc(-c2ccc(F)c(Cl)c2)c(c1)C(F)(F)F)C(O)=O |r| Show InChI InChI=1S/C17H13ClF4N2O3/c18-12-5-8(1-4-13(12)19)10-3-2-9(6-11(10)17(20,21)22)24-15(25)7-14(23)16(26)27/h1-6,14H,7,23H2,(H,24,25)(H,26,27)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410458 (CHEMBL2113123) Show SMILES Cc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H17F3N2O3/c1-10-7-12(11-3-2-4-13(8-11)18(19,20)21)5-6-15(10)23-16(24)9-14(22)17(25)26/h2-8,14H,9,22H2,1H3,(H,23,24)(H,25,26)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410459 (CHEMBL2113117) Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(Br)ccc-23)c1)C(O)=O |r| Show InChI InChI=1S/C17H15BrN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50197049 (CHEMBL458273) Show SMILES N[C@@H]([C@H](Cc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO4/c12-9(11(15)16)8(10(13)14)6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EAAT3 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintilla...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00342 BindingDB Entry DOI: 10.7270/Q2WH2TQZ
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366638 (CHEMBL4166966) Show SMILES N[C@@H]([C@H](OCC#C)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C7H9NO5/c1-2-3-13-5(7(11)12)4(8)6(9)10/h1,4-5H,3,8H2,(H,9,10)(H,11,12)/t4-,5-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410461 (CHEMBL2113126) Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-6-11(21-16(22)8-15(20)17(23)24)3-4-12(9)10-2-5-13(18)14(19)7-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366638 (CHEMBL4166966) Show SMILES N[C@@H]([C@H](OCC#C)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C7H9NO5/c1-2-3-13-5(7(11)12)4(8)6(9)10/h1,4-5H,3,8H2,(H,9,10)(H,11,12)/t4-,5-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	851	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366610 (CHEMBL4169695) Show SMILES N[C@@H]([C@H](OCc1ccsc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO5S/c10-6(8(11)12)7(9(13)14)15-3-5-1-2-16-4-5/h1-2,4,6-7H,3,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366610 (CHEMBL4169695) Show SMILES N[C@@H]([C@H](OCc1ccsc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO5S/c10-6(8(11)12)7(9(13)14)15-3-5-1-2-16-4-5/h1-2,4,6-7H,3,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366610 (CHEMBL4169695) Show SMILES N[C@@H]([C@H](OCc1ccsc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO5S/c10-6(8(11)12)7(9(13)14)15-3-5-1-2-16-4-5/h1-2,4,6-7H,3,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366610 (CHEMBL4169695) Show SMILES N[C@@H]([C@H](OCc1ccsc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO5S/c10-6(8(11)12)7(9(13)14)15-3-5-1-2-16-4-5/h1-2,4,6-7H,3,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	871	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50196924 (CHEMBL3960774) Show SMILES N[C@@H](C(NS(=O)(=O)c1ccc(Cl)cc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H11ClN2O6S/c11-5-1-3-6(4-2-5)20(18,19)13-8(10(16)17)7(12)9(14)15/h1-4,7-8,13H,12H2,(H,14,15)(H,16,17)/t7-,8?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	977	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method				J Med Chem 59: 8771-8786 (2016) Article DOI: 10.1021/acs.jmedchem.6b01066 BindingDB Entry DOI: 10.7270/Q2Z03B4C
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50196924 (CHEMBL3960774) Show SMILES N[C@@H](C(NS(=O)(=O)c1ccc(Cl)cc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H11ClN2O6S/c11-5-1-3-6(4-2-5)20(18,19)13-8(10(16)17)7(12)9(14)15/h1-4,7-8,13H,12H2,(H,14,15)(H,16,17)/t7-,8?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method				J Med Chem 59: 8771-8786 (2016) Article DOI: 10.1021/acs.jmedchem.6b01066 BindingDB Entry DOI: 10.7270/Q2Z03B4C
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50173935 (2-Amino-N-biphenyl-4-yl-succinamic acid | CHEMBL19...) Show SMILES NC(CC(=O)Nc1ccc(cc1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C16H16N2O3/c17-14(16(20)21)10-15(19)18-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,14H,10,17H2,(H,18,19)(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50173914 (2-Amino-N-(3'-chloro-4'-fluoro-6-methyl-biphenyl-3...) Show SMILES Cc1ccc(NC(=O)CC(N)C(O)=O)cc1-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C17H16ClFN2O3/c1-9-2-4-11(21-16(22)8-15(20)17(23)24)7-12(9)10-3-5-14(19)13(18)6-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50173917 (2-Amino-N-(10-ethyl-10H-phenoxazin-2-yl)-succinami...) Show SMILES CCN1c2ccccc2Oc2ccc(NC(=O)CC(N)C(O)=O)cc12 Show InChI InChI=1S/C18H19N3O4/c1-2-21-13-5-3-4-6-15(13)25-16-8-7-11(9-14(16)21)20-17(22)10-12(19)18(23)24/h3-9,12H,2,10,19H2,1H3,(H,20,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366617 (CHEMBL4163105) Show SMILES N[C@@H]([C@H](OCc1cccs1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO5S/c10-6(8(11)12)7(9(13)14)15-4-5-2-1-3-16-5/h1-3,6-7H,4,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50197054 (CHEMBL3937517) Show SMILES N[C@@H]([C@H](NS(=O)(=O)c1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H12N2O6S/c11-7(9(13)14)8(10(15)16)12-19(17,18)6-4-2-1-3-5-6/h1-5,7-8,12H,11H2,(H,13,14)(H,15,16)/t7-,8-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method				J Med Chem 59: 8771-8786 (2016) Article DOI: 10.1021/acs.jmedchem.6b01066 BindingDB Entry DOI: 10.7270/Q2Z03B4C
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366655 (CHEMBL4177165) Show SMILES N[C@@H]([C@H](OCc1ccoc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO6/c10-6(8(11)12)7(9(13)14)16-4-5-1-2-15-3-5/h1-3,6-7H,4,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366617 (CHEMBL4163105) Show SMILES N[C@@H]([C@H](OCc1cccs1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO5S/c10-6(8(11)12)7(9(13)14)15-4-5-2-1-3-16-5/h1-3,6-7H,4,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366655 (CHEMBL4177165) Show SMILES N[C@@H]([C@H](OCc1ccoc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO6/c10-6(8(11)12)7(9(13)14)16-4-5-1-2-15-3-5/h1-3,6-7H,4,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50197054 (CHEMBL3937517) Show SMILES N[C@@H]([C@H](NS(=O)(=O)c1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H12N2O6S/c11-7(9(13)14)8(10(15)16)12-19(17,18)6-4-2-1-3-5-6/h1-5,7-8,12H,11H2,(H,13,14)(H,15,16)/t7-,8-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method				J Med Chem 59: 8771-8786 (2016) Article DOI: 10.1021/acs.jmedchem.6b01066 BindingDB Entry DOI: 10.7270/Q2Z03B4C
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50410452 (CHEMBL2113125) Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-13(20-16(21)9-15(19)17(22)23)6-7-14(10)11-2-4-12(18)5-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3				Bioorg Med Chem Lett 15: 4985-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.003 BindingDB Entry DOI: 10.7270/Q25H7FSP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366650 (CHEMBL4166282) Show SMILES N[C@@H]([C@H](OCC#N)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C6H8N2O5/c7-1-2-13-4(6(11)12)3(8)5(9)10/h3-4H,2,8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366640 (CHEMBL4166545) Show SMILES N[C@@H]([C@H](OCc1ccco1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO6/c10-6(8(11)12)7(9(13)14)16-4-5-2-1-3-15-5/h1-3,6-7H,4,10H2,(H,11,12)(H,13,14)/t6-,7-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50366650 (CHEMBL4166282) Show SMILES N[C@@H]([C@H](OCC#N)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C6H8N2O5/c7-1-2-13-4(6(11)12)3(8)5(9)10/h3-4H,2,8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair

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