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Compile Data Set for Download or QSAR

Found 25 hits of ic50 for UniProtKB: P43367   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50503849
PNG
(CHEMBL4590466)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C=O |r|
Show InChI InChI=1S/C29H39N3O5/c1-20(2)15-24(18-33)30-27(34)25(16-21(3)4)31-28(35)26(17-22-11-7-5-8-12-22)32-29(36)37-19-23-13-9-6-10-14-23/h5-14,18,20-21,24-26H,15-17,19H2,1-4H3,(H,30,34)(H,31,35)(H,32,36)/t24-,25-,26-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...


Bioorg Med Chem 27: 436-441 (2019)


Article DOI: 10.1016/j.bmc.2018.12.022
BindingDB Entry DOI: 10.7270/Q2NP27P1
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189833
PNG
((S)-N-butyl-3-((S)-2-(4-fluorophenylsulfonamido)-3...)
Show SMILES CCCCNC(=O)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C
Show InChI InChI=1S/C22H34FN3O5S/c1-6-7-12-24-22(29)20(27)18(13-14(2)3)25-21(28)19(15(4)5)26-32(30,31)17-10-8-16(23)9-11-17/h8-11,14-15,18-19,26H,6-7,12-13H2,1-5H3,(H,24,29)(H,25,28)/t18-,19-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50503846
PNG
(CHEMBL4540394)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O |r|
Show InChI InChI=1S/C32H37N3O5/c1-23(2)18-28(30(37)33-27(21-36)19-24-12-6-3-7-13-24)34-31(38)29(20-25-14-8-4-9-15-25)35-32(39)40-22-26-16-10-5-11-17-26/h3-17,21,23,27-29H,18-20,22H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)/t27-,28-,29-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...


Bioorg Med Chem 27: 436-441 (2019)


Article DOI: 10.1016/j.bmc.2018.12.022
BindingDB Entry DOI: 10.7270/Q2NP27P1
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50503847
PNG
(CHEMBL4574306)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(OCC#C)cc1)C=O |r|
Show InChI InChI=1S/C35H39N3O6/c1-4-19-43-30-17-15-27(16-18-30)21-29(23-39)36-33(40)31(20-25(2)3)37-34(41)32(22-26-11-7-5-8-12-26)38-35(42)44-24-28-13-9-6-10-14-28/h1,5-18,23,25,29,31-32H,19-22,24H2,2-3H3,(H,36,40)(H,37,41)(H,38,42)/t29-,31-,32-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...


Bioorg Med Chem 27: 436-441 (2019)


Article DOI: 10.1016/j.bmc.2018.12.022
BindingDB Entry DOI: 10.7270/Q2NP27P1
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50114340
PNG
((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C=O |r|
Show InChI InChI=1S/C17H25FN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22)/t14-,16-/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50263559
PNG
(((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-...)
Show SMILES COCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C25H37N3O7/c1-17(2)15-21(28-25(32)35-14-13-34-12-11-33-3)23(30)27-20(16-18-7-5-4-6-8-18)22(29)24(31)26-19-9-10-19/h4-8,17,19-21H,9-16H2,1-3H3,(H,26,31)(H,27,30)(H,28,32)/t20-,21-/m0/s1
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n/an/a 99n/an/an/an/an/an/a



Senju Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of pig kidney m-calpain


Bioorg Med Chem Lett 18: 5174-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.089
BindingDB Entry DOI: 10.7270/Q2P55NBS
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50263560
PNG
(2-methoxyethyl (S)-1-((S)-4-(cyclopropylamino)-3,4...)
Show SMILES COCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C23H33N3O6/c1-15(2)13-19(26-23(30)32-12-11-31-3)21(28)25-18(14-16-7-5-4-6-8-16)20(27)22(29)24-17-9-10-17/h4-8,15,17-19H,9-14H2,1-3H3,(H,24,29)(H,25,28)(H,26,30)/t18-,19-/m0/s1
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Senju Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of pig kidney m-calpain


Bioorg Med Chem Lett 18: 5174-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.089
BindingDB Entry DOI: 10.7270/Q2P55NBS
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189825
PNG
((2S)-2-((((4-cyanophenyl)amino)thioxomethyl)amino)...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1ccc(cc1)C#N)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C18H24N4O3S/c1-11(2)9-15(16(23)21-14-7-8-25-17(14)24)22-18(26)20-13-5-3-12(10-19)4-6-13/h3-6,11,14-15,17,24H,7-9H2,1-2H3,(H,21,23)(H2,20,22,26)/t14-,15-,17?/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50263561
PNG
(2-(2-(2-methoxyethoxy)ethoxy)ethyl (S)-1-((S)-4-(c...)
Show SMILES COCCOCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C27H41N3O8/c1-19(2)17-23(30-27(34)38-16-15-37-14-13-36-12-11-35-3)25(32)29-22(18-20-7-5-4-6-8-20)24(31)26(33)28-21-9-10-21/h4-8,19,21-23H,9-18H2,1-3H3,(H,28,33)(H,29,32)(H,30,34)/t22-,23-/m0/s1
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Senju Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of pig kidney m-calpain


Bioorg Med Chem Lett 18: 5174-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.089
BindingDB Entry DOI: 10.7270/Q2P55NBS
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50503845
PNG
(CHEMBL4531762)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O |r|
Show InChI InChI=1S/C23H35N3O6/c1-15(2)10-18(12-27)24-22(30)20(13-28)25-21(29)19(11-16(3)4)26-23(31)32-14-17-8-6-5-7-9-17/h5-9,12,15-16,18-20,28H,10-11,13-14H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t18-,19-,20-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...


Bioorg Med Chem 27: 436-441 (2019)


Article DOI: 10.1016/j.bmc.2018.12.022
BindingDB Entry DOI: 10.7270/Q2NP27P1
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189834
PNG
((2S)-2-((((3-cyanophenyl)amino)thioxomethyl)amino)...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1cccc(c1)C#N)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C18H24N4O3S/c1-11(2)8-15(16(23)21-14-6-7-25-17(14)24)22-18(26)20-13-5-3-4-12(9-13)10-19/h3-5,9,11,14-15,17,24H,6-8H2,1-2H3,(H,21,23)(H2,20,22,26)/t14-,15-,17?/m0/s1
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Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189832
PNG
((2S)-4-methyl-2-((((4-methylphenyl)amino)thioxomet...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1ccc(C)cc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C18H27N3O3S/c1-11(2)10-15(16(22)20-14-8-9-24-17(14)23)21-18(25)19-13-6-4-12(3)5-7-13/h4-7,11,14-15,17,23H,8-10H2,1-3H3,(H,20,22)(H2,19,21,25)/t14-,15-,17?/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50263613
PNG
(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyl (S)-1...)
Show SMILES COCCOCCOCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C29H45N3O9/c1-21(2)19-25(32-29(36)41-18-17-40-16-15-39-14-13-38-12-11-37-3)27(34)31-24(20-22-7-5-4-6-8-22)26(33)28(35)30-23-9-10-23/h4-8,21,23-25H,9-20H2,1-3H3,(H,30,35)(H,31,34)(H,32,36)/t24-,25-/m0/s1
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Senju Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of pig kidney m-calpain


Bioorg Med Chem Lett 18: 5174-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.089
BindingDB Entry DOI: 10.7270/Q2P55NBS
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50263558
PNG
(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)e...)
Show SMILES COCCOCCOCCOCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C31H49N3O10/c1-23(2)21-27(34-31(38)44-20-19-43-18-17-42-16-15-41-14-13-40-12-11-39-3)29(36)33-26(22-24-7-5-4-6-8-24)28(35)30(37)32-25-9-10-25/h4-8,23,25-27H,9-22H2,1-3H3,(H,32,37)(H,33,36)(H,34,38)/t26-,27-/m0/s1
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Senju Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of pig kidney m-calpain


Bioorg Med Chem Lett 18: 5174-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.089
BindingDB Entry DOI: 10.7270/Q2P55NBS
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189835
PNG
((2S)-2-((((4-fluorophenyl)amino)thioxomethyl)amino...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1ccc(F)cc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C17H24FN3O3S/c1-10(2)9-14(15(22)20-13-7-8-24-16(13)23)21-17(25)19-12-5-3-11(18)4-6-12/h3-6,10,13-14,16,23H,7-9H2,1-2H3,(H,20,22)(H2,19,21,25)/t13-,14-,16?/m0/s1
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Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189828
PNG
(1-((S)-1-((3S)-2-hydroxy-tetrahydrofuran-3-ylamino...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C17H25N3O3S/c1-11(2)10-14(15(21)19-13-8-9-23-16(13)22)20-17(24)18-12-6-4-3-5-7-12/h3-7,11,13-14,16,22H,8-10H2,1-2H3,(H,19,21)(H2,18,20,24)/t13-,14-,16?/m0/s1
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Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189827
PNG
((2S)-2-((((4-methoxyphenyl)amino)thioxomethyl)amin...)
Show SMILES COc1ccc(NC(=S)N[C@@H](CC(C)C)C(=O)N[C@H]2CCOC2O)cc1
Show InChI InChI=1S/C18H27N3O4S/c1-11(2)10-15(16(22)20-14-8-9-25-17(14)23)21-18(26)19-12-4-6-13(24-3)7-5-12/h4-7,11,14-15,17,23H,8-10H2,1-3H3,(H,20,22)(H2,19,21,26)/t14-,15-,17?/m0/s1
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Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189822
PNG
((2S)-2-((benzylamino)thioxomethyl)amino)-4-methyl-...)
Show SMILES CC(C)C[C@H](NC(=S)NCc1ccccc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C18H27N3O3S/c1-12(2)10-15(16(22)20-14-8-9-24-17(14)23)21-18(25)19-11-13-6-4-3-5-7-13/h3-7,12,14-15,17,23H,8-11H2,1-2H3,(H,20,22)(H2,19,21,25)/t14-,15-,17?/m0/s1
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Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189830
PNG
((2S)-4-methyl-2-((((2-methylphenyl)amino)thioxomet...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1ccccc1C)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C18H27N3O3S/c1-11(2)10-15(16(22)19-14-8-9-24-17(14)23)21-18(25)20-13-7-5-4-6-12(13)3/h4-7,11,14-15,17,23H,8-10H2,1-3H3,(H,19,22)(H2,20,21,25)/t14-,15-,17?/m0/s1
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n/an/a 250n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189831
PNG
((2S)-4-methyl-2-((((3-methylphenyl)amino)thioxomet...)
Show SMILES CC(C)C[C@H](NC(=S)Nc1cccc(C)c1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C18H27N3O3S/c1-11(2)9-15(16(22)20-14-7-8-24-17(14)23)21-18(25)19-13-6-4-5-12(3)10-13/h4-6,10-11,14-15,17,23H,7-9H2,1-3H3,(H,20,22)(H2,19,21,25)/t14-,15-,17?/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189823
PNG
((2S,3S)-3-methyl-2-(((phenylamino)thioxomethyl)ami...)
Show SMILES CC[C@H](C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C17H25N3O3S/c1-3-11(2)14(15(21)19-13-9-10-23-16(13)22)20-17(24)18-12-7-5-4-6-8-12/h4-8,11,13-14,16,22H,3,9-10H2,1-2H3,(H,19,21)(H2,18,20,24)/t11-,13-,14-,16?/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189829
PNG
((2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)...)
Show SMILES CC(C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C16H23N3O3S/c1-10(2)13(14(20)18-12-8-9-22-15(12)21)19-16(23)17-11-6-4-3-5-7-11/h3-7,10,12-13,15,21H,8-9H2,1-2H3,(H,18,20)(H2,17,19,23)/t12-,13-,15?/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189826
PNG
((S)-2-(4-fluorophenylsulfonamido)-N-((3S)-2-hydrox...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@H]1CCOC1O
Show InChI InChI=1S/C15H21FN2O5S/c1-9(2)13(14(19)17-12-7-8-23-15(12)20)18-24(21,22)11-5-3-10(16)4-6-11/h3-6,9,12-13,15,18,20H,7-8H2,1-2H3,(H,17,19)/t12-,13-,15?/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50503848
PNG
(CHEMBL4475662)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C29H45N3O6/c1-18(2)13-22(25(33)29(7)17-38-29)30-26(34)23(14-19(3)4)31-27(35)24(15-20(5)6)32-28(36)37-16-21-11-9-8-10-12-21/h8-12,18-20,22-24H,13-17H2,1-7H3,(H,30,34)(H,31,35)(H,32,36)/t22-,23-,24-,29+/m0/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of recombinant porcine calpain 2 protease using BODIPY-FL casein as substrate measured at 30 secs time interval for 30 mins by fluorescenc...


Bioorg Med Chem 27: 436-441 (2019)


Article DOI: 10.1016/j.bmc.2018.12.022
BindingDB Entry DOI: 10.7270/Q2NP27P1
More data for this
Ligand-Target Pair
Calpain-2 catalytic subunit


(Sus scrofa)
BDBM50189824
PNG
(CHEMBL206737 | N-(1-cyano-3-methylbutyl)-2-((4-flu...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C#N
Show InChI InChI=1S/C17H24FN3O3S/c1-11(2)9-14(10-19)20-17(22)16(12(3)4)21-25(23,24)15-7-5-13(18)6-8-15/h5-8,11-12,14,16,21H,9H2,1-4H3,(H,20,22)/t14-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Senju Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of porcein kidney m calpain


J Med Chem 49: 3926-32 (2006)


Article DOI: 10.1021/jm060157n
BindingDB Entry DOI: 10.7270/Q21R6Q48
More data for this
Ligand-Target Pair