Compile Data Set for Download or QSAR

Found 14 hits of ic50 for UniProtKB: P36506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498024 (CHEMBL3326332) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cccc(NCC[C@H](O)CO)c2o1 |r| Show InChI InChI=1S/C20H22N2O5/c1-26-17-7-3-5-14(19(17)21)18-10-16(25)13-4-2-6-15(20(13)27-18)22-9-8-12(24)11-23/h2-7,10,12,22-24H,8-9,11,21H2,1H3/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Rattus norvegicus)	BDBM50498018 (CHEMBL3326331) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cccc(NCCCO)c2o1 Show InChI InChI=1S/C19H20N2O4/c1-24-16-8-3-6-13(18(16)20)17-11-15(23)12-5-2-7-14(19(12)25-17)21-9-4-10-22/h2-3,5-8,11,21-22H,4,9-10,20H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498026 (CHEMBL3326319) Show SMILES CCOc1cccc(c1N)-c1cc(=O)c2ccccc2o1 Show InChI InChI=1S/C17H15NO3/c1-2-20-15-9-5-7-12(17(15)18)16-10-13(19)11-6-3-4-8-14(11)21-16/h3-10H,2,18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498028 (CHEMBL3326325) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NCCCO)c2o1 Show InChI InChI=1S/C19H19ClN2O4/c1-25-16-5-2-4-12(18(16)21)17-10-15(24)13-8-11(20)9-14(19(13)26-17)22-6-3-7-23/h2,4-5,8-10,22-23H,3,6-7,21H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498030 (CHEMBL3326326) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NCC[C@H](O)CO)c2o1 |r| Show InChI InChI=1S/C20H21ClN2O5/c1-27-17-4-2-3-13(19(17)22)18-9-16(26)14-7-11(21)8-15(20(14)28-18)23-6-5-12(25)10-24/h2-4,7-9,12,23-25H,5-6,10,22H2,1H3/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50108771 (2'-amino-3'-methoxyflavone | 2-(2-Amino-3-methoxy-...) Show SMILES COc1cccc(c1N)-c1cc(=O)c2ccccc2o1 Show InChI InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498029 (CHEMBL3326323) Show SMILES CCCCNc1cc(Cl)cc2c1oc(cc2=O)-c1cccc(OC)c1N Show InChI InChI=1S/C20H21ClN2O3/c1-3-4-8-23-15-10-12(21)9-14-16(24)11-18(26-20(14)15)13-6-5-7-17(25-2)19(13)22/h5-7,9-11,23H,3-4,8,22H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498027 (CHEMBL3326329) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NCc3ccccc3)c2o1 Show InChI InChI=1S/C23H19ClN2O3/c1-28-20-9-5-8-16(22(20)25)21-12-19(27)17-10-15(24)11-18(23(17)29-21)26-13-14-6-3-2-4-7-14/h2-12,26H,13,25H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498025 (CHEMBL3326324) Show SMILES COCCCNc1cc(Cl)cc2c1oc(cc2=O)-c1cccc(OC)c1N Show InChI InChI=1S/C20H21ClN2O4/c1-25-8-4-7-23-15-10-12(21)9-14-16(24)11-18(27-20(14)15)13-5-3-6-17(26-2)19(13)22/h3,5-6,9-11,23H,4,7-8,22H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498022 (CHEMBL3326328) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NCCCN)c2o1 Show InChI InChI=1S/C19H20ClN3O3/c1-25-16-5-2-4-12(18(16)22)17-10-15(24)13-8-11(20)9-14(19(13)26-17)23-7-3-6-21/h2,4-5,8-10,23H,3,6-7,21-22H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498021 (CHEMBL3326327) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NCCCN(C)C)c2o1 Show InChI InChI=1S/C21H24ClN3O3/c1-25(2)9-5-8-24-16-11-13(22)10-15-17(26)12-19(28-21(15)16)14-6-4-7-18(27-3)20(14)23/h4,6-7,10-12,24H,5,8-9,23H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498020 (CHEMBL3326320) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)ccc2o1 Show InChI InChI=1S/C16H12ClNO3/c1-20-14-4-2-3-10(16(14)18)15-8-12(19)11-7-9(17)5-6-13(11)21-15/h2-8H,18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498019 (CHEMBL3326322) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NC(C)C)c2o1 Show InChI InChI=1S/C19H19ClN2O3/c1-10(2)22-14-8-11(20)7-13-15(23)9-17(25-19(13)14)12-5-4-6-16(24-3)18(12)21/h4-10,22H,21H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Rattus norvegicus)	BDBM50498023 (CHEMBL3326330) Show SMILES COc1cccc(c1N)-c1cc(=O)c2cc(Cl)cc(NC3CCOCC3)c2o1 Show InChI InChI=1S/C21H21ClN2O4/c1-26-18-4-2-3-14(20(18)23)19-11-17(25)15-9-12(22)10-16(21(15)28-19)24-13-5-7-27-8-6-13/h2-4,9-11,13,24H,5-8,23H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...				Eur J Med Chem 85: 127-38 (2014) Article DOI: 10.1016/j.ejmech.2014.07.018 BindingDB Entry DOI: 10.7270/Q2Z322NF
					More data for this Ligand-Target Pair