Found 7 hits of ic50 data for polymerid = 50000511 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50514449
(CHEMBL4171381)Show SMILES CCC(=O)N[C@@H]([C@H](O)C(C)C)C(=O)O[C@H](C(C)C)[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@H](OC(=O)[C@H]([C@@H](C)OC)N(C)C1=O)C(C)C |r| Show InChI InChI=1S/C49H75N7O15/c1-17-34(58)52-35(39(59)24(2)3)47(65)70-40(25(4)5)36-46(64)56(15)38(30(11)68-16)49(67)71-41(26(6)7)37(51-31(12)57)48(66)69-33(23-32-21-19-18-20-22-32)45(63)55(14)28(9)42(60)50-27(8)44(62)54(13)29(10)43(61)53-36/h18-22,24-27,29-30,33,35-41,59H,9,17,23H2,1-8,10-16H3,(H,50,60)(H,51,57)(H,52,58)(H,53,61)/t27-,29-,30+,33+,35-,36-,37-,38-,39+,40+,41+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Galphaq/11 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01977
BindingDB Entry DOI: 10.7270/Q2W099PS |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50468902
(CHEMBL4288881)Show SMILES CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r| Show InChI InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20,22-24,26-28,32-38,56H,6,21H2,1-5,7-15H3,(H,47,57)(H,48,54)(H,49,55)(H,50,58)/t24-,26-,27+,28+,32+,33-,34-,35-,36-,37+,38+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-alphaq/11 in human platelet rich plasma assessed as inhibition of ADP-mediated calcium ion mobilization |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50468902
(CHEMBL4288881)Show SMILES CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r| Show InChI InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20,22-24,26-28,32-38,56H,6,21H2,1-5,7-15H3,(H,47,57)(H,48,54)(H,49,55)(H,50,58)/t24-,26-,27+,28+,32+,33-,34-,35-,36-,37+,38+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Galphaq/11 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01977
BindingDB Entry DOI: 10.7270/Q2W099PS |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50577153
(CHEMBL4873047)Show SMILES C\C=C1/N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@H](OC1=O)C(C)C)[C@H](OC(=O)[C@@H](NC(C)=O)[C@@H](O)C(C)C)C(C)C |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of wild type GNAQ (unknown origin) expressed in CRISPR/Cas9 engineered HEK293 cells |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.1c00194
BindingDB Entry DOI: 10.7270/Q2ZK5MGS |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50566319
(CHEMBL4877306)Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1CCn2cc(nc2[C@@H]1CC1CCCCC1)-c1ccccc1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Galphaq/11 (unknown origin) expressed in CHO cells coexpressing M1 receptor assessed as reduction in carbachol-induced IP1 accumulation... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01977
BindingDB Entry DOI: 10.7270/Q2W099PS |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50566320
(CHEMBL4867175)Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCn2cc(nc2[C@@H]1CC1CCCCC1)-c1ccccc1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Galphaq/11 (unknown origin) expressed in CHO cells coexpressing M1 receptor assessed as reduction in carbachol-induced IP1 accumulation... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01977
BindingDB Entry DOI: 10.7270/Q2W099PS |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50566319
(CHEMBL4877306)Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1CCn2cc(nc2[C@@H]1CC1CCCCC1)-c1ccccc1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Galphaq/11 (unknown origin) expressed in HEK293 cells cotransfected with AT1R/Galphaq-RLuc8/ Ggamma2-venus/Gbeta1 assessed as inh... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01977
BindingDB Entry DOI: 10.7270/Q2W099PS |
More data for this
Ligand-Target Pair | |
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