Found 6 hits of ic50 for UniProtKB: P36956 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sterol regulatory element-binding protein 1
(Homo sapiens) | BDBM50351538
(CHEMBL1824673)Show SMILES CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C18H19N3O2S2/c1-3-4-16-11-14(9-10-19-16)18-20-17(12-24-18)13-5-7-15(8-6-13)21-25(2,22)23/h5-12,21H,3-4H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02179
BindingDB Entry DOI: 10.7270/Q2D79G6N |
More data for this
Ligand-Target Pair | |
Sterol regulatory element-binding protein 1
(Homo sapiens) | BDBM50571643
(CHEMBL4851466)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\Cn1nnnc1-c1ccccc1)[C@H](C)CCC(F)(F)C(C)(C)O |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 723 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02179
BindingDB Entry DOI: 10.7270/Q2D79G6N |
More data for this
Ligand-Target Pair | |
Sterol regulatory element-binding protein 1
(Homo sapiens) | BDBM50571642
(CHEMBL4876668)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\Cn1nnc(n1)-c1ccc(F)cc1)[C@H](C)CCC(F)(F)C(C)(C)O |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02179
BindingDB Entry DOI: 10.7270/Q2D79G6N |
More data for this
Ligand-Target Pair | |
Sterol regulatory element-binding protein 1
(Homo sapiens) | BDBM50521013
(CHEBI:17933 | Calcifediol)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)(C)O Show InChI InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02179
BindingDB Entry DOI: 10.7270/Q2D79G6N |
More data for this
Ligand-Target Pair | |
Sterol regulatory element-binding protein 1
(Homo sapiens) | BDBM50571644
(CHEMBL4851396)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\Cn1nnnc1-c1ccc(F)cc1)[C@H](C)CCC(F)(F)C(C)(C)O |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02179
BindingDB Entry DOI: 10.7270/Q2D79G6N |
More data for this
Ligand-Target Pair | |
Sterol regulatory element-binding protein 1
(Homo sapiens) | BDBM50351521
(CHEMBL1824658)Show InChI InChI=1S/C17H16N2S/c1-3-15-10-14(8-9-18-15)17-19-16(11-20-17)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02179
BindingDB Entry DOI: 10.7270/Q2D79G6N |
More data for this
Ligand-Target Pair | |
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