Found 13 hits of ic50 for UniProtKB: P70605 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215069
(1,2,3-tris-[3-(4-(N-ethyl)-quinoliniumylamino)-pro...)Show SMILES CCn1cc\c(=[NH+]\CCCOc2cccc(OCCCNc3cc[n+](CC)c4ccccc34)c2OCCC\[NH+]=c2/ccn(CC)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C48H54N6O3/c1-4-52-31-25-40(37-17-7-10-20-43(37)52)49-28-14-34-55-46-23-13-24-47(56-35-15-29-50-41-26-32-53(5-2)44-21-11-8-18-38(41)44)48(46)57-36-16-30-51-42-27-33-54(6-3)45-22-12-9-19-39(42)45/h7-13,17-27,31-33H,4-6,14-16,28-30,34-36H2,1-3H3/p+3/b49-40-,51-42+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215071
(CHEMBL375272 | N-[3-(4-quinolinylamino)-propyl]-N-...)Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)c1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1 Show InChI InChI=1S/C56H59N9O2/c1(10-27-57-53-23-31-61-49-19-6-2-15-45(49)53)11-35-65(36-12-28-58-54-24-32-62-50-20-7-3-16-46(50)54)42-39-43(66-37-13-29-59-55-25-33-63-51-21-8-4-17-47(51)55)41-44(40-42)67-38-14-30-60-56-26-34-64-52-22-9-5-18-48(52)56/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215070
(1,2,3-tri[3-(4-quinolinylamino)-propoxy]-benzene |...)Show SMILES C(CNc1ccnc2ccccc12)COc1cccc(OCCCNc2ccnc3ccccc23)c1OCCCNc1ccnc2ccccc12 Show InChI InChI=1S/C42H42N6O3/c1-4-14-34-31(11-1)37(19-25-46-34)43-22-8-28-49-40-17-7-18-41(50-29-9-23-44-38-20-26-47-35-15-5-2-12-32(35)38)42(40)51-30-10-24-45-39-21-27-48-36-16-6-3-13-33(36)39/h1-7,11-21,25-27H,8-10,22-24,28-30H2,(H,43,46)(H,44,47)(H,45,48) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215076
(CHEMBL229982 | N-[3-(4-quinolinylamino)-propyl]-N-...)Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)Cc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1 Show InChI InChI=1S/C57H61N9O2/c1(10-27-58-54-23-31-62-50-19-6-2-15-46(50)54)11-35-66(36-12-28-59-55-24-32-63-51-20-7-3-16-47(51)55)42-43-39-44(67-37-13-29-60-56-25-33-64-52-21-8-4-17-48(52)56)41-45(40-43)68-38-14-30-61-57-26-34-65-53-22-9-5-18-49(53)57/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38,42H2,(H,58,62)(H,59,63)(H,60,64)(H,61,65) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215075
(CHEMBL229818 | N-[3-(4-quinolinylamino)-propyl]-3,...)Show SMILES C(CNc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C42H43N7O2/c1-4-13-37-34(10-1)40(16-23-47-37)44-20-7-19-43-31-28-32(50-26-8-21-45-41-17-24-48-38-14-5-2-11-35(38)41)30-33(29-31)51-27-9-22-46-42-18-25-49-39-15-6-3-12-36(39)42/h1-6,10-18,23-25,28-30,43H,7-9,19-22,26-27H2,(H,44,47)(H,45,48)(H,46,49) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215072
(CHEMBL389273 | N-(4-quinolinyl)-3,4-di-[3-(4-quino...)Show SMILES C(CNc1ccnc2ccccc12)COc1ccc(CCNc2ccnc3ccccc23)cc1OCCCNc1ccnc2ccccc12 Show InChI InChI=1S/C41H40N6O2/c1-4-12-34-31(9-1)37(18-24-45-34)42-21-7-27-48-40-16-15-30(17-23-44-39-20-26-47-36-14-6-3-11-33(36)39)29-41(40)49-28-8-22-43-38-19-25-46-35-13-5-2-10-32(35)38/h1-6,9-16,18-20,24-26,29H,7-8,17,21-23,27-28H2,(H,42,45)(H,43,46)(H,44,47) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215068
(CHEMBL229341 | N-[3-(4-quinolinylamino)-proyl]-3,5...)Show SMILES C(CNCc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C43H45N7O2/c1-4-13-38-35(10-1)41(16-23-48-38)45-20-7-19-44-31-32-28-33(51-26-8-21-46-42-17-24-49-39-14-5-2-11-36(39)42)30-34(29-32)52-27-9-22-47-43-18-25-50-40-15-6-3-12-37(40)43/h1-6,10-18,23-25,28-30,44H,7-9,19-22,26-27,31H2,(H,45,48)(H,46,49)(H,47,50) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215073
(CHEMBL229340 | N-[3-(4-quinolinyl)-aminopropyl]-N-...)Show SMILES NCCCCCCCCN(CCCNc1ccnc2ccccc12)C(=O)\C=C\C(=O)NCCCNc1ccnc2ccccc12 Show InChI InChI=1S/C36H47N7O2/c37-21-9-3-1-2-4-10-27-43(28-12-24-39-34-20-26-41-32-16-8-6-14-30(32)34)36(45)18-17-35(44)42-23-11-22-38-33-19-25-40-31-15-7-5-13-29(31)33/h5-8,13-20,25-26H,1-4,9-12,21-24,27-28,37H2,(H,38,40)(H,39,41)(H,42,44)/b18-17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50377980
(CHEMBL558625)Show SMILES C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]1OC(=O)c2c1ccc1OCOc21 |r| Show InChI InChI=1S/C21H20NO6/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3/q+1/t18-,19+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch A/S
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique |
J Med Chem 51: 7625-34 (2009)
Article DOI: 10.1021/jm800809f
BindingDB Entry DOI: 10.7270/Q28S4QT0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215074
(CHEMBL425668 | N-(3-guanidinopropyl)-N-[4-(4'-amin...)Show SMILES [#7]-[#6]-c1ccc(cc1)-c1ccc(-[#6]-[#7](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#6]=[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])cc1 |w:24.25| Show InChI InChI=1S/C26H37N9O2/c27-17-19-3-7-21(8-4-19)22-9-5-20(6-10-22)18-35(16-2-15-34-26(30)31)24(37)12-11-23(36)32-13-1-14-33-25(28)29/h3-12H,1-2,13-18,27H2,(H,32,36)(H4,28,29,33)(H4,30,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215079
(4,4'bis(guanidinomethyl)-cis-stilbene | CHEMBL2291...)Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-c1ccc(\[#6]=[#6]/c2ccc(-[#6]\[#7]=[#6](\[#7])-[#7])cc2)cc1 Show InChI InChI=1S/C18H22N6/c19-17(20)23-11-15-7-3-13(4-8-15)1-2-14-5-9-16(10-6-14)12-24-18(21)22/h1-10H,11-12H2,(H4,19,20,23)(H4,21,22,24)/b2-1- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215078
(CHEMBL373955 | N-(3-guanidinopropyl)-N(8-aminoocty...)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#6]=[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] |w:20.20| Show InChI InChI=1S/C20H41N9O2/c21-11-5-3-1-2-4-6-15-29(16-8-14-28-20(24)25)18(31)10-9-17(30)26-12-7-13-27-19(22)23/h9-10H,1-8,11-16,21H2,(H,26,30)(H4,22,23,27)(H4,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 3
(Rattus norvegicus) | BDBM50215077
(CHEMBL390821 | N-(3-guanidinopropyl)-N-(8-aminooct...)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#6]=[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] |w:20.20| Show InChI InChI=1S/C20H41N9O2/c21-11-5-3-1-2-4-6-15-29(16-8-14-28-20(24)25)18(31)10-9-17(30)26-12-7-13-27-19(22)23/h9-10H,1-8,11-16,21H2,(H,26,30)(H4,22,23,27)(H4,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London
Curated by ChEMBL
| Assay Description
Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons |
Bioorg Med Chem 15: 5457-79 (2007)
Article DOI: 10.1016/j.bmc.2007.05.054
BindingDB Entry DOI: 10.7270/Q2416WSJ |
More data for this
Ligand-Target Pair | |
Search and Browse
