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Compile Data Set for Download or QSAR

Found 4 hits of kd for UniProtKB: P47809   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity mitogen-activated protein kinase kinase 4


(Mus musculus)
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/an/a 8.20n/an/an/an/an/a


TBA

Assay Description
Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112963
BindingDB Entry DOI: 10.7270/Q2MW2MXG
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4


(Mus musculus)
BDBM50568580
PNG
(CHEMBL4857316)
Show SMILES Fc1c(NS(=O)(=O)Cc2ccccc2)cccc1C(=O)c1c[nH]c2ncc(cc12)-c1cnc(nc1)C1CC1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.10n/an/an/an/an/a


TBA

Assay Description
Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112963
BindingDB Entry DOI: 10.7270/Q2MW2MXG
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4


(Mus musculus)
BDBM50568579
PNG
(CHEMBL4848804)
Show SMILES COc1ncc(cn1)-c1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 0.850n/an/an/an/an/a


TBA

Assay Description
Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112963
BindingDB Entry DOI: 10.7270/Q2MW2MXG
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4


(Mus musculus)
BDBM50568578
PNG
(CHEMBL4868537)
Show SMILES Fc1c(NS(=O)(=O)Cc2ccccc2)cccc1C(=O)c1c[nH]c2ncc(cc12)-c1cc2OCCOc2cc1Cl
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 3.5n/an/an/an/an/a


TBA

Assay Description
Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112963
BindingDB Entry DOI: 10.7270/Q2MW2MXG
More data for this
Ligand-Target Pair