Found 7 hits of ic50 for UniProtKB: P28472 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50106149
(1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-4-(3-tri...)Show SMILES FC(F)(F)c1cc(Cl)c(c(Cl)c1)-n1cc(cn1)C1(N=N1)C(F)(F)F |c:20| Show InChI InChI=1S/C12H4Cl2F6N4/c13-7-1-5(11(15,16)17)2-8(14)9(7)24-4-6(3-21-24)10(22-23-10)12(18,19)20/h1-4H | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-EBOB binding to human GABA-A receptor beta3 subunit (range 1-28) |
Bioorg Med Chem Lett 11: 2979-81 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6QTJ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50106148
(5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]...)Show SMILES Nc1c(c(nn1-c1c(Cl)cc(cc1Cl)C(F)(F)F)C#N)S(=O)C(F)(F)F |(7.75,-3.07,;6.27,-2.6,;5.81,-1.15,;4.26,-1.15,;3.77,-2.62,;5.03,-3.52,;5.06,-5.06,;6.39,-5.83,;7.72,-5.05,;6.39,-7.39,;5.06,-8.16,;3.73,-7.39,;3.73,-5.83,;2.39,-5.07,;5.06,-9.7,;3.82,-10.73,;6.32,-10.73,;5.06,-11.11,;3.35,.09,;2.43,1.35,;6.69,.11,;6.06,1.52,;8.24,-.05,;9.31,-.92,;8.92,1.36,;9.62,.13,)| Show InChI InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-EBOB binding to drosophila GABA-A receptor (range 1-28) |
Bioorg Med Chem Lett 11: 2979-81 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6QTJ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50106149
(1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-4-(3-tri...)Show SMILES FC(F)(F)c1cc(Cl)c(c(Cl)c1)-n1cc(cn1)C1(N=N1)C(F)(F)F |c:20| Show InChI InChI=1S/C12H4Cl2F6N4/c13-7-1-5(11(15,16)17)2-8(14)9(7)24-4-6(3-21-24)10(22-23-10)12(18,19)20/h1-4H | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-EBOB binding to human GABA-A receptor beta3 subunit (range 1-28) |
Bioorg Med Chem Lett 11: 2979-81 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6QTJ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50106148
(5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]...)Show SMILES Nc1c(c(nn1-c1c(Cl)cc(cc1Cl)C(F)(F)F)C#N)S(=O)C(F)(F)F |(7.75,-3.07,;6.27,-2.6,;5.81,-1.15,;4.26,-1.15,;3.77,-2.62,;5.03,-3.52,;5.06,-5.06,;6.39,-5.83,;7.72,-5.05,;6.39,-7.39,;5.06,-8.16,;3.73,-7.39,;3.73,-5.83,;2.39,-5.07,;5.06,-9.7,;3.82,-10.73,;6.32,-10.73,;5.06,-11.11,;3.35,.09,;2.43,1.35,;6.69,.11,;6.06,1.52,;8.24,-.05,;9.31,-.92,;8.92,1.36,;9.62,.13,)| Show InChI InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-EBOB binding to drosophila GABA-A receptor (range 1-28) |
Bioorg Med Chem Lett 11: 2979-81 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6QTJ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50395121
(CHEMBL2163548)Show SMILES CN1C(=O)NC(=O)[C@](CC=C)(C1=O)c1cccc(c1)C1(N=N1)C(F)(F)F |r,c:22| Show InChI InChI=1S/C16H13F3N4O3/c1-3-7-14(11(24)20-13(26)23(2)12(14)25)9-5-4-6-10(8-9)15(21-22-15)16(17,18)19/h3-6,8H,1,7H2,2H3,(H,20,24,26)/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description
Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells |
J Med Chem 55: 6554-65 (2012)
Article DOI: 10.1021/jm300631e
BindingDB Entry DOI: 10.7270/Q25B03MX |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50055935
(5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidi...)Show InChI InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 8.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description
Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells |
J Med Chem 55: 6554-65 (2012)
Article DOI: 10.1021/jm300631e
BindingDB Entry DOI: 10.7270/Q25B03MX |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit beta-3
(Homo sapiens (Human)) | BDBM50395120
(CHEMBL2163549)Show SMILES CN1C(=O)NC(=O)[C@@](CC=C)(C1=O)c1cccc(c1)C1(N=N1)C(F)(F)F |r,c:22| Show InChI InChI=1S/C16H13F3N4O3/c1-3-7-14(11(24)20-13(26)23(2)12(14)25)9-5-4-6-10(8-9)15(21-22-15)16(17,18)19/h3-6,8H,1,7H2,2H3,(H,20,24,26)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description
Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells |
J Med Chem 55: 6554-65 (2012)
Article DOI: 10.1021/jm300631e
BindingDB Entry DOI: 10.7270/Q25B03MX |
More data for this
Ligand-Target Pair | |
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