Compile Data Set for Download or QSAR

Found 14 hits of ec50 for UniProtKB: P63079   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-4/beta-3 (Rattus norvegicus (Rat))	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha4beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta (Rattus norvegicus (Rat))	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3 (Rattus norvegicus (Rat))	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta (Rattus norvegicus (Rat))	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha4beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 (RAT-Rattus norvegicus)	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha6beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta (Rattus norvegicus (Rat))	BDBM50457445 (CHEMBL4212818) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2ccccn12)-c1cccs1 Show InChI InChI=1S/C18H12ClN3OS/c19-13-8-6-12(7-9-13)18(23)21-17-16(14-4-3-11-24-14)20-15-5-1-2-10-22(15)17/h1-11H,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	860	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 (Rattus norvegicus (Rat)-RAT)	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	870	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta (Rattus norvegicus (Rat))	BDBM50457445 (CHEMBL4212818) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2ccccn12)-c1cccs1 Show InChI InChI=1S/C18H12ClN3OS/c19-13-8-6-12(7-9-13)18(23)21-17-16(14-4-3-11-24-14)20-15-5-1-2-10-22(15)17/h1-11H,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	970	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha4beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Rattus norvegicus (Rat))	BDBM50457439 (CHEMBL4213357) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2c(Br)cc(Br)cn12)-c1cccs1 Show InChI InChI=1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.01E+3	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 (RAT-Rattus norvegicus)	BDBM50457445 (CHEMBL4212818) Show SMILES Clc1ccc(cc1)C(=O)Nc1c(nc2ccccn12)-c1cccs1 Show InChI InChI=1S/C18H12ClN3OS/c19-13-8-6-12(7-9-13)18(23)21-17-16(14-4-3-11-24-14)20-15-5-1-2-10-22(15)17/h1-11H,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a
Johannes Gutenberg University Mainz Curated by ChEMBL					Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha6beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assay				J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2 (Rattus norvegicus (Rat)-RAT)	BDBM50452383 (CHEMBL4218339) Show SMILES CC(C)[C@@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=S |r,t:4| Show InChI InChI=1S/C18H17ClN2S/c1-11(2)16-18(22)20-15-9-8-13(19)10-14(15)17(21-16)12-6-4-3-5-7-12/h3-11,16H,1-2H3,(H,20,22)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>2.40E+4	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development Curated by ChEMBL					Assay Description Displacement of [3H]-flumazenil from rat GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assay				Bioorg Med Chem Lett 27: 5415-5419 (2017) Article DOI: 10.1016/j.bmcl.2017.11.008 BindingDB Entry DOI: 10.7270/Q27D2XQ8
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Rattus norvegicus (Rat))	BDBM50452383 (CHEMBL4218339) Show SMILES CC(C)[C@@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=S |r,t:4| Show InChI InChI=1S/C18H17ClN2S/c1-11(2)16-18(22)20-15-9-8-13(19)10-14(15)17(21-16)12-6-4-3-5-7-12/h3-11,16H,1-2H3,(H,20,22)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>2.40E+4	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development Curated by ChEMBL					Assay Description Displacement of [3H]-flumazenil from rat GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assay				Bioorg Med Chem Lett 27: 5415-5419 (2017) Article DOI: 10.1016/j.bmcl.2017.11.008 BindingDB Entry DOI: 10.7270/Q27D2XQ8
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2 (Rattus norvegicus (Rat))	BDBM50452383 (CHEMBL4218339) Show SMILES CC(C)[C@@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=S |r,t:4| Show InChI InChI=1S/C18H17ClN2S/c1-11(2)16-18(22)20-15-9-8-13(19)10-14(15)17(21-16)12-6-4-3-5-7-12/h3-11,16H,1-2H3,(H,20,22)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>2.40E+4	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development Curated by ChEMBL					Assay Description Displacement of [3H]-flumazenil from rat GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assay				Bioorg Med Chem Lett 27: 5415-5419 (2017) Article DOI: 10.1016/j.bmcl.2017.11.008 BindingDB Entry DOI: 10.7270/Q27D2XQ8
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Mus musculus-Rattus norvegicus (Rat))	BDBM50229715 (CHEMBL4070615) Show SMILES [H][C@]12CN([C@@H](C)[C@@]1([H])C(=O)N(C)c1ccncc21)S(=O)(=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C19H19N3O5S/c1-11-18-14(13-8-20-6-5-15(13)21(2)19(18)23)9-22(11)28(24,25)12-3-4-16-17(7-12)27-10-26-16/h3-8,11,14,18H,9-10H2,1-2H3/t11-,14+,18+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 assessed as increase in GABA-induced current response at -60 mV hold...				Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR
					More data for this Ligand-Target Pair