Found 6 hits of ic50 for UniProtKB: P16638 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ATP-citrate synthase
(Rattus norvegicus) | BDBM50394674
(CHEMBL2165254)Show InChI InChI=1S/C15H11ClO4/c1-6-2-7-4-8-5-10(18)13(16)15(20)12(8)14(19)11(7)9(17)3-6/h2-3,5,17-18,20H,4H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACLY |
J Med Chem 54: 5615-38 (2011)
Article DOI: 10.1021/jm2005805
BindingDB Entry DOI: 10.7270/Q21N8261 |
More data for this
Ligand-Target Pair | |
ATP-citrate synthase
(Rattus norvegicus) | BDBM50394674
(CHEMBL2165254)Show InChI InChI=1S/C15H11ClO4/c1-6-2-7-4-8-5-10(18)13(16)15(20)12(8)14(19)11(7)9(17)3-6/h2-3,5,17-18,20H,4H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat liver ATP citrate lyase using tripotassium citrate as substrate by malate dehydrogenase-based oxaloacetate reduction assay |
Eur J Med Chem 126: 920-928 (2017)
Article DOI: 10.1016/j.ejmech.2016.12.018
BindingDB Entry DOI: 10.7270/Q2028TSK |
More data for this
Ligand-Target Pair | |
ATP-citrate synthase
(Rattus norvegicus) | BDBM50394674
(CHEMBL2165254)Show InChI InChI=1S/C15H11ClO4/c1-6-2-7-4-8-5-10(18)13(16)15(20)12(8)14(19)11(7)9(17)3-6/h2-3,5,17-18,20H,4H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pisa
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACLY by MDH enzyme coupled assay |
Eur J Med Chem 157: 1276-1291 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.001
BindingDB Entry DOI: 10.7270/Q2N0197R |
More data for this
Ligand-Target Pair | |
ATP-citrate synthase
(Rattus norvegicus) | BDBM50469147
(CHEMBL4281691)Show SMILES CC1=CC(O)=C2C(=O)c3c(O)c(ccc3OC2(C)C1=O)-c1ccc2OC3(C)C(OC(=O)CC(O)=O)C4(C)OC4C(O)=C3C(=O)c2c1O |c:44,t:1,4| Show InChI InChI=1S/C33H26O14/c1-11-9-14(34)21-25(40)19-15(45-31(21,2)28(11)43)7-5-12(23(19)38)13-6-8-16-20(24(13)39)26(41)22-27(42)29-33(4,47-29)30(32(22,3)46-16)44-18(37)10-17(35)36/h5-9,29-30,34,38-39,42H,10H2,1-4H3,(H,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pisa
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACLY |
Eur J Med Chem 157: 1276-1291 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.001
BindingDB Entry DOI: 10.7270/Q2N0197R |
More data for this
Ligand-Target Pair | |
ATP-citrate synthase
(Rattus norvegicus) | BDBM50394675
(PURPURONE)Show SMILES Oc1ccc(CCn2c3=C(C(=O)c4cc(O)c(O)cc4-c3c3-c4cc(O)c(O)cc4C(=O)C(c4ccc(O)c(O)c4)=c23)c2ccc(O)c(O)c2)cc1 |t:8,44| Show InChI InChI=1S/C40H27NO11/c42-20-5-1-17(2-6-20)9-10-41-37-33(18-3-7-25(43)27(45)11-18)39(51)23-15-31(49)29(47)13-21(23)35(37)36-22-14-30(48)32(50)16-24(22)40(52)34(38(36)41)19-4-8-26(44)28(46)12-19/h1-8,11-16,42-50H,9-10H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACLY |
J Med Chem 54: 5615-38 (2011)
Article DOI: 10.1021/jm2005805
BindingDB Entry DOI: 10.7270/Q21N8261 |
More data for this
Ligand-Target Pair | |
ATP-citrate synthase
(Rattus norvegicus) | BDBM50469153
(CHEMBL4292319)Show SMILES CC12OC1C(O)=C1C(=O)c3c(O)c(ccc3OC1(C)C2O)-c1ccc2OC3(C)C(OC(=O)CC(O)=O)C4(C)OC4C(O)=C3C(=O)c2c1O |c:46,t:6| Show InChI InChI=1S/C33H28O15/c1-30-18(24(41)26-32(3,47-26)28(30)43)22(39)16-12(45-30)7-5-10(20(16)37)11-6-8-13-17(21(11)38)23(40)19-25(42)27-33(4,48-27)29(31(19,2)46-13)44-15(36)9-14(34)35/h5-8,26-29,37-38,41-43H,9H2,1-4H3,(H,34,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pisa
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACLY |
Eur J Med Chem 157: 1276-1291 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.001
BindingDB Entry DOI: 10.7270/Q2N0197R |
More data for this
Ligand-Target Pair | |
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