Found 31 hits of ic50 for UniProtKB: P28088 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelin receptor type B
(Bos taurus) | BDBM50043326
(CHEMBL438733 | c(Cys-Ser-Cys)-Ser-Ser-Leu-Met-Asp-...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]2CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(160)81-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)/t56-,57-,64+,66+,67-,68+,69-,70-,71-,72+,73-,74-,75-,76-,77-,78+,79-,80-,81+,82+,86-,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0930 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50000558
(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)/t56-,57-,64+,66-,67-,68-,69+,70-,71-,72+,73-,74+,75-,76-,77+,78-,79+,80-,81-,82+,86-,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50043322
(CHEMBL427748 | c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C109H159N25O32S5/c1-12-57(10)88(108(164)126-77(109(165)166)39-60-43-113-65-23-17-16-22-63(60)65)134-100(156)71(36-55(6)7)119-99(155)76(42-86(143)144)124-94(150)70(35-54(4)5)118-97(153)74(40-61-44-112-52-114-61)122-104(160)81-49-169-168-48-64(111)89(145)127-78(45-135)103(159)132-82-50-170-171-51-83(106(162)133-87(56(8)9)107(163)125-73(38-59-25-27-62(138)28-26-59)95(151)121-72(96(152)131-81)37-58-20-14-13-15-21-58)130-91(147)67(29-30-84(139)140)116-90(146)66(24-18-19-32-110)115-98(154)75(41-85(141)142)123-92(148)68(31-33-167-11)117-93(149)69(34-53(2)3)120-101(157)79(46-136)128-102(158)80(47-137)129-105(82)161/h13-17,20-23,25-28,43-44,52-57,64,66-83,87-88,113,135-138H,12,18-19,24,29-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,155)(H,120,157)(H,121,151)(H,122,160)(H,123,148)(H,124,150)(H,125,163)(H,126,164)(H,127,145)(H,128,158)(H,129,161)(H,130,147)(H,131,152)(H,132,159)(H,133,162)(H,134,156)(H,139,140)(H,141,142)(H,143,144)(H,165,166)/t57-,64+,66+,67-,68+,69-,70-,71-,72-,73+,74-,75-,76-,77-,78-,79+,80-,81-,82+,83+,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50368776
(CHEMBL1790962)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C109H161N25O31S5/c1-13-57(10)87(107(162)125-77(109(164)165)40-61-43-113-66-24-18-17-23-64(61)66)133-98(153)72(37-55(6)7)123-108(163)88(58(11)138)134-99(154)71(36-54(4)5)118-96(151)75(41-62-44-112-52-114-62)121-103(158)81-49-168-167-48-65(111)89(144)126-78(45-135)102(157)131-82-50-169-170-51-83(105(160)132-86(56(8)9)106(161)124-74(39-60-26-28-63(139)29-27-60)94(149)120-73(95(150)130-81)38-59-21-15-14-16-22-59)129-91(146)68(30-31-84(140)141)116-90(145)67(25-19-20-33-110)115-97(152)76(42-85(142)143)122-92(147)69(32-34-166-12)117-93(148)70(35-53(2)3)119-100(155)79(46-136)127-101(156)80(47-137)128-104(82)159/h14-18,21-24,26-29,43-44,52-58,65,67-83,86-88,113,135-139H,13,19-20,25,30-42,45-51,110-111H2,1-12H3,(H,112,114)(H,115,152)(H,116,145)(H,117,148)(H,118,151)(H,119,155)(H,120,149)(H,121,158)(H,122,147)(H,123,163)(H,124,161)(H,125,162)(H,126,144)(H,127,156)(H,128,159)(H,129,146)(H,130,150)(H,131,157)(H,132,160)(H,133,153)(H,134,154)(H,140,141)(H,142,143)(H,164,165)/t57-,58-,65+,67+,68-,69+,70?,71-,72-,73-,74+,75-,76-,77-,78-,79+,80-,81-,82+,83+,86-,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289647
(CHEMBL263855 | Compound RES-701-1(1-10)/[A15]ET-1)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C117H150N28O27/c1-12-60(7)97(113(167)140-89(117(171)172)43-69-51-123-78-31-22-19-28-75(69)78)144-114(168)98(61(8)13-2)143-110(164)88(48-95(152)153)137-103(157)79(38-58(3)4)132-106(160)85(45-71-53-120-57-127-71)131-100(154)62(9)128-102(156)80(39-65-24-15-14-16-25-65)133-104(158)81(40-66-33-35-72(147)36-34-66)139-112(166)96(59(5)6)142-109(163)83(42-68-50-122-77-30-21-18-27-74(68)77)135-108(162)87-47-92(149)124-54-93(150)130-86(46-91(118)148)107(161)134-82(41-67-49-121-76-29-20-17-26-73(67)76)105(159)136-84(44-70-52-119-56-126-70)101(155)125-55-94(151)141-99(64(11)146)115(169)129-63(10)116(170)145-37-23-32-90(145)111(165)138-87/h14-22,24-31,33-36,49-53,56-64,79-90,96-99,121-123,146-147H,12-13,23,32,37-48,54-55H2,1-11H3,(H2,118,148)(H,119,126)(H,120,127)(H,124,149)(H,125,155)(H,128,156)(H,129,169)(H,130,150)(H,131,154)(H,132,160)(H,133,158)(H,134,161)(H,135,162)(H,136,159)(H,137,157)(H,138,165)(H,139,166)(H,140,167)(H,141,151)(H,142,163)(H,143,164)(H,144,168)(H,152,153)(H,171,172)/t60-,61-,62-,63-,64+,79-,80-,81-,82-,83-,84+,85-,86+,87+,88-,89-,90+,96-,97-,98-,99+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50368772
(CHEMBL2373291)Show SMILES [H][C@@]12CSSC[C@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C112H165N25O31S5/c1-11-59(8)90(110(165)128-80(112(167)168)43-64-46-116-69-27-19-18-26-67(64)69)136-102(157)77(41-62-24-16-13-17-25-62)127-111(166)91(60(9)141)137-101(156)74(39-57(4)5)121-99(154)78(44-65-47-115-55-117-65)124-106(161)84-52-171-170-51-68(114)92(147)129-81(48-138)105(160)134-85-53-172-173-54-86(108(163)135-89(58(6)7)109(164)126-76(42-63-29-31-66(142)32-30-63)97(152)123-75(98(153)133-84)40-61-22-14-12-15-23-61)132-94(149)71(33-34-87(143)144)119-93(148)70(28-20-21-36-113)118-100(155)79(45-88(145)146)125-95(150)72(35-37-169-10)120-96(151)73(38-56(2)3)122-103(158)82(49-139)130-104(159)83(50-140)131-107(85)162/h12,14-15,18-19,22-23,26-27,29-32,46-47,55-60,62,68,70-86,89-91,116,138-142H,11,13,16-17,20-21,24-25,28,33-45,48-54,113-114H2,1-10H3,(H,115,117)(H,118,155)(H,119,148)(H,120,151)(H,121,154)(H,122,158)(H,123,152)(H,124,161)(H,125,150)(H,126,164)(H,127,166)(H,128,165)(H,129,147)(H,130,159)(H,131,162)(H,132,149)(H,133,153)(H,134,160)(H,135,163)(H,136,157)(H,137,156)(H,143,144)(H,145,146)(H,167,168)/t59-,60+,68+,70+,71-,72+,73-,74-,75-,76+,77-,78-,79?,80-,81-,82+,83-,84-,85+,86-,89-,90-,91-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50368774
(CHEMBL1790963)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C109H161N25O31S5/c1-13-56(9)86(106(161)124-76(109(164)165)40-61-43-113-66-25-19-18-24-64(61)66)132-107(162)87(57(10)14-2)133-108(163)88(58(11)138)134-98(153)71(37-54(5)6)118-96(151)74(41-62-44-112-52-114-62)121-102(157)80-49-168-167-48-65(111)89(144)125-77(45-135)101(156)130-81-50-169-170-51-82(104(159)131-85(55(7)8)105(160)123-73(39-60-27-29-63(139)30-28-60)94(149)120-72(95(150)129-80)38-59-22-16-15-17-23-59)128-91(146)68(31-32-83(140)141)116-90(145)67(26-20-21-34-110)115-97(152)75(42-84(142)143)122-92(147)69(33-35-166-12)117-93(148)70(36-53(3)4)119-99(154)78(46-136)126-100(155)79(47-137)127-103(81)158/h15-19,22-25,27-30,43-44,52-58,65,67-82,85-88,113,135-139H,13-14,20-21,26,31-42,45-51,110-111H2,1-12H3,(H,112,114)(H,115,152)(H,116,145)(H,117,148)(H,118,151)(H,119,154)(H,120,149)(H,121,157)(H,122,147)(H,123,160)(H,124,161)(H,125,144)(H,126,155)(H,127,158)(H,128,146)(H,129,150)(H,130,156)(H,131,159)(H,132,162)(H,133,163)(H,134,153)(H,140,141)(H,142,143)(H,164,165)/t56-,57-,58+,65+,67+,68-,69+,70-,71-,72-,73+,74-,75-,76-,77-,78+,79-,80-,81+,82+,85-,86-,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50368777
(CHEMBL2373292)Show SMILES [H][C@@]12CSSC[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C110H163N25O31S5/c1-14-57(8)87(107(163)125-76(109(165)166)40-61-44-114-66-25-19-18-24-64(61)66)134-99(155)77(43-110(10,11)12)126-108(164)88(58(9)139)135-98(154)71(37-55(4)5)119-96(152)74(41-62-45-113-53-115-62)122-103(159)81-50-169-168-49-65(112)89(145)127-78(46-136)102(158)132-82-51-170-171-52-83(105(161)133-86(56(6)7)106(162)124-73(39-60-27-29-63(140)30-28-60)94(150)121-72(95(151)131-81)38-59-22-16-15-17-23-59)130-91(147)68(31-32-84(141)142)117-90(146)67(26-20-21-34-111)116-97(153)75(42-85(143)144)123-92(148)69(33-35-167-13)118-93(149)70(36-54(2)3)120-100(156)79(47-137)128-101(157)80(48-138)129-104(82)160/h15-19,22-25,27-30,44-45,53-58,65,67-83,86-88,114,136-140H,14,20-21,26,31-43,46-52,111-112H2,1-13H3,(H,113,115)(H,116,153)(H,117,146)(H,118,149)(H,119,152)(H,120,156)(H,121,150)(H,122,159)(H,123,148)(H,124,162)(H,125,163)(H,126,164)(H,127,145)(H,128,157)(H,129,160)(H,130,147)(H,131,151)(H,132,158)(H,133,161)(H,134,155)(H,135,154)(H,141,142)(H,143,144)(H,165,166)/t57-,58+,65+,67+,68-,69+,70?,71-,72-,73+,74-,75-,76-,77-,78-,79+,80-,81-,82+,83+,86-,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50043324
(CHEMBL411171 | c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C111H165N25O30S5/c1-14-59(11)89(109(163)127-79(111(165)166)42-63-45-115-68-26-20-19-25-66(63)68)136-110(164)90(60(12)15-2)135-101(155)74(39-57(7)8)121-96(150)73(38-56(5)6)120-99(153)77(43-64-46-114-54-116-64)124-105(159)83-51-169-168-50-67(113)91(145)128-80(47-137)104(158)133-84-52-170-171-53-85(107(161)134-88(58(9)10)108(162)126-76(41-62-28-30-65(140)31-29-62)97(151)123-75(98(152)132-83)40-61-23-17-16-18-24-61)131-93(147)70(32-33-86(141)142)118-92(146)69(27-21-22-35-112)117-100(154)78(44-87(143)144)125-94(148)71(34-36-167-13)119-95(149)72(37-55(3)4)122-102(156)81(48-138)129-103(157)82(49-139)130-106(84)160/h16-20,23-26,28-31,45-46,54-60,67,69-85,88-90,115,137-140H,14-15,21-22,27,32-44,47-53,112-113H2,1-13H3,(H,114,116)(H,117,154)(H,118,146)(H,119,149)(H,120,153)(H,121,150)(H,122,156)(H,123,151)(H,124,159)(H,125,148)(H,126,162)(H,127,163)(H,128,145)(H,129,157)(H,130,160)(H,131,147)(H,132,152)(H,133,158)(H,134,161)(H,135,155)(H,136,164)(H,141,142)(H,143,144)(H,165,166)/t59-,60-,67+,69+,70-,71+,72-,73-,74-,75-,76+,77-,78-,79-,80-,81+,82-,83-,84+,85+,88-,89-,90-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd.
Curated by ChEMBL
| Assay Description
Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptor |
J Med Chem 36: 4087-93 (1994)
BindingDB Entry DOI: 10.7270/Q2FT8MPC |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289650
(CHEMBL414047 | Compound RES-701-1(1-10)/[A15]ET-3)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C117H150N28O28/c1-12-59(7)97(113(168)140-89(117(172)173)42-68-50-123-78-26-19-16-23-75(68)78)144-114(169)98(60(8)13-2)143-110(165)88(47-95(153)154)137-103(158)79(37-57(3)4)132-106(161)85(44-70-52-120-56-127-70)131-100(155)61(9)128-102(157)80(38-64-28-32-71(147)33-29-64)133-104(159)81(39-65-30-34-72(148)35-31-65)139-112(167)96(58(5)6)142-109(164)83(41-67-49-122-77-25-18-15-22-74(67)77)135-108(163)87-46-92(150)124-53-93(151)130-86(45-91(118)149)107(162)134-82(40-66-48-121-76-24-17-14-21-73(66)76)105(160)136-84(43-69-51-119-55-126-69)101(156)125-54-94(152)141-99(63(11)146)115(170)129-62(10)116(171)145-36-20-27-90(145)111(166)138-87/h14-19,21-26,28-35,48-52,55-63,79-90,96-99,121-123,146-148H,12-13,20,27,36-47,53-54H2,1-11H3,(H2,118,149)(H,119,126)(H,120,127)(H,124,150)(H,125,156)(H,128,157)(H,129,170)(H,130,151)(H,131,155)(H,132,161)(H,133,159)(H,134,162)(H,135,163)(H,136,160)(H,137,158)(H,138,166)(H,139,167)(H,140,168)(H,141,152)(H,142,164)(H,143,165)(H,144,169)(H,153,154)(H,172,173)/t59-,60-,61-,62-,63+,79-,80-,81-,82-,83-,84+,85-,86+,87+,88-,89-,90+,96-,97-,98-,99+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289648
(CHEMBL408437 | Compound RES-701-1(1-10)/[A15]SRTX6...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C116H147N29O28/c1-10-59(6)97(113(169)141-88(116(172)173)42-67-50-123-76-28-19-16-25-73(67)76)144-112(168)96(58(4)5)143-110(166)87(47-95(153)154)139-101(157)77(34-35-90(117)148)131-107(163)84(44-69-52-120-56-127-69)132-99(155)60(7)128-102(158)79(38-63-21-12-11-13-22-63)134-104(160)80(39-64-30-32-70(147)33-31-64)135-103(159)78(37-57(2)3)133-105(161)81(40-65-48-121-74-26-17-14-23-71(65)74)137-109(165)86-46-92(150)124-53-93(151)130-85(45-91(118)149)108(164)136-82(41-66-49-122-75-27-18-15-24-72(66)75)106(162)138-83(43-68-51-119-55-126-68)100(156)125-54-94(152)142-98(62(9)146)114(170)129-61(8)115(171)145-36-20-29-89(145)111(167)140-86/h11-19,21-28,30-33,48-52,55-62,77-89,96-98,121-123,146-147H,10,20,29,34-47,53-54H2,1-9H3,(H2,117,148)(H2,118,149)(H,119,126)(H,120,127)(H,124,150)(H,125,156)(H,128,158)(H,129,170)(H,130,151)(H,131,163)(H,132,155)(H,133,161)(H,134,160)(H,135,159)(H,136,164)(H,137,165)(H,138,162)(H,139,157)(H,140,167)(H,141,169)(H,142,152)(H,143,166)(H,144,168)(H,153,154)(H,172,173)/t59-,60-,61-,62+,77-,78-,79-,80-,81-,82-,83+,84-,85+,86+,87-,88-,89+,96-,97-,98+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289112
(CHEMBL438745 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(O)=O Show InChI InChI=1S/C105H116N22O23/c1-56-104(148)127-37-15-26-85(127)102(146)124-83(49-88(133)111-53-89(134)115-81(47-86(106)131)99(143)120-79(45-66-51-110-73-25-14-12-23-71(66)73)98(142)122-80(46-67-52-108-55-113-67)92(136)112-54-90(135)126-91(57(2)128)103(147)114-56)101(145)121-78(44-65-50-109-72-24-13-11-22-70(65)72)97(141)118-74(39-58-16-5-3-6-17-58)93(137)116-75(40-59-18-7-4-8-19-59)95(139)123-82(48-87(107)132)100(144)119-76(41-60-28-33-68(129)34-29-60)94(138)117-77(42-61-30-35-69(130)36-31-61)96(140)125-84(105(149)150)43-62-27-32-63-20-9-10-21-64(63)38-62/h3-14,16-25,27-36,38,50-52,55-57,74-85,91,109-110,128-130H,15,26,37,39-49,53-54H2,1-2H3,(H2,106,131)(H2,107,132)(H,108,113)(H,111,133)(H,112,136)(H,114,147)(H,115,134)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,145)(H,122,142)(H,123,139)(H,124,146)(H,125,140)(H,126,135)(H,149,150)/t56-,57+,74-,75-,76-,77-,78-,79-,80+,81+,82-,83+,84+,85+,91+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289108
(CHEMBL384792 | RES-701-1 | RES-701-1-C-terminal an...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(46-86(132)110-51-87(133)114-79(44-84(104)130)97(142)119-77(41-61-48-108-70-24-13-10-21-67(61)70)96(141)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)99(144)120-76(40-60-47-107-69-23-12-9-20-66(60)69)95(140)117-72(36-56-16-5-3-6-17-56)91(136)115-73(37-57-18-7-4-8-19-57)93(138)122-80(45-85(105)131)98(143)118-74(38-58-27-31-64(128)32-28-58)92(137)116-75(39-59-29-33-65(129)34-30-59)94(139)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,132)(H,111,135)(H,113,146)(H,114,133)(H,115,136)(H,116,137)(H,117,140)(H,118,143)(H,119,142)(H,120,144)(H,121,141)(H,122,138)(H,123,145)(H,124,139)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81+,82-,83+,89+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289108
(CHEMBL384792 | RES-701-1 | RES-701-1-C-terminal an...)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(46-86(132)110-51-87(133)114-79(44-84(104)130)97(142)119-77(41-61-48-108-70-24-13-10-21-67(61)70)96(141)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)99(144)120-76(40-60-47-107-69-23-12-9-20-66(60)69)95(140)117-72(36-56-16-5-3-6-17-56)91(136)115-73(37-57-18-7-4-8-19-57)93(138)122-80(45-85(105)131)98(143)118-74(38-58-27-31-64(128)32-28-58)92(137)116-75(39-59-29-33-65(129)34-30-59)94(139)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,132)(H,111,135)(H,113,146)(H,114,133)(H,115,136)(H,116,137)(H,117,140)(H,118,143)(H,119,142)(H,120,144)(H,121,141)(H,122,138)(H,123,145)(H,124,139)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81+,82-,83+,89+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289111
(CHEMBL411057 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(46-86(132)110-51-87(133)114-79(44-84(104)130)97(142)119-77(41-61-48-108-70-24-13-10-21-67(61)70)96(141)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)99(144)120-76(40-60-47-107-69-23-12-9-20-66(60)69)95(140)117-72(36-56-16-5-3-6-17-56)91(136)115-73(37-57-18-7-4-8-19-57)93(138)122-80(45-85(105)131)98(143)118-74(38-58-27-31-64(128)32-28-58)92(137)116-75(39-59-29-33-65(129)34-30-59)94(139)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,132)(H,111,135)(H,113,146)(H,114,133)(H,115,136)(H,116,137)(H,117,140)(H,118,143)(H,119,142)(H,120,144)(H,121,141)(H,122,138)(H,123,145)(H,124,139)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81+,82+,83+,89+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289107
(CHEMBL263294 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C101H114N22O23/c1-54-100(144)123-36-16-27-81(123)98(142)120-79(47-84(129)107-51-85(130)111-77(45-82(102)127)95(139)116-75(43-62-49-106-69-26-15-13-24-67(62)69)94(138)118-76(44-63-50-104-53-109-63)88(132)108-52-86(131)122-87(55(2)124)99(143)110-54)97(141)117-74(42-61-48-105-68-25-14-12-23-66(61)68)93(137)114-70(37-56-17-6-3-7-18-56)89(133)112-71(38-57-19-8-4-9-20-57)91(135)119-78(46-83(103)128)96(140)115-72(39-59-28-32-64(125)33-29-59)90(134)113-73(40-60-30-34-65(126)35-31-60)92(136)121-80(101(145)146)41-58-21-10-5-11-22-58/h3-15,17-26,28-35,48-50,53-55,70-81,87,105-106,124-126H,16,27,36-47,51-52H2,1-2H3,(H2,102,127)(H2,103,128)(H,104,109)(H,107,129)(H,108,132)(H,110,143)(H,111,130)(H,112,133)(H,113,134)(H,114,137)(H,115,140)(H,116,139)(H,117,141)(H,118,138)(H,119,135)(H,120,142)(H,121,136)(H,122,131)(H,145,146)/t54-,55+,70-,71-,72-,73-,74-,75-,76+,77+,78-,79+,80+,81+,87+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289113
(CHEMBL267754 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C114H125N25O24/c1-60-113(161)139-39-17-30-93(139)111(159)136-91(51-96(145)122-57-97(146)126-89(49-94(115)143)108(156)132-86(45-67-53-119-78-27-14-10-23-74(67)78)106(154)134-88(48-70-56-117-59-124-70)100(148)123-58-98(147)138-99(61(2)140)112(160)125-60)110(158)133-85(44-66-52-118-77-26-13-9-22-73(66)77)105(153)129-81(40-62-18-5-3-6-19-62)101(149)127-82(41-63-20-7-4-8-21-63)104(152)135-90(50-95(116)144)109(157)130-83(42-64-31-35-71(141)36-32-64)102(150)128-84(43-65-33-37-72(142)38-34-65)103(151)131-87(46-68-54-120-79-28-15-11-24-75(68)79)107(155)137-92(114(162)163)47-69-55-121-80-29-16-12-25-76(69)80/h3-16,18-29,31-38,52-56,59-61,81-93,99,118-121,140-142H,17,30,39-51,57-58H2,1-2H3,(H2,115,143)(H2,116,144)(H,117,124)(H,122,145)(H,123,148)(H,125,160)(H,126,146)(H,127,149)(H,128,150)(H,129,153)(H,130,157)(H,131,151)(H,132,156)(H,133,158)(H,134,154)(H,135,152)(H,136,159)(H,137,155)(H,138,147)(H,162,163)/t60-,61+,81-,82-,83-,84-,85-,86-,87-,88+,89+,90-,91+,92-,93+,99+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289117
(CHEMBL407422 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C101H114N22O24/c1-53-100(145)123-35-13-22-81(123)98(143)120-79(46-84(130)107-50-85(131)111-77(44-82(102)128)95(140)116-75(42-61-48-106-69-21-12-10-19-67(61)69)94(139)118-76(43-62-49-104-52-109-62)88(133)108-51-86(132)122-87(54(2)124)99(144)110-53)97(142)117-74(41-60-47-105-68-20-11-9-18-66(60)68)93(138)114-70(36-55-14-5-3-6-15-55)89(134)112-71(37-56-16-7-4-8-17-56)91(136)119-78(45-83(103)129)96(141)115-72(38-57-23-29-63(125)30-24-57)90(135)113-73(39-58-25-31-64(126)32-26-58)92(137)121-80(101(146)147)40-59-27-33-65(127)34-28-59/h3-12,14-21,23-34,47-49,52-54,70-81,87,105-106,124-127H,13,22,35-46,50-51H2,1-2H3,(H2,102,128)(H2,103,129)(H,104,109)(H,107,130)(H,108,133)(H,110,144)(H,111,131)(H,112,134)(H,113,135)(H,114,138)(H,115,141)(H,116,140)(H,117,142)(H,118,139)(H,119,136)(H,120,143)(H,121,137)(H,122,132)(H,146,147)/t53-,54+,70-,71-,72-,73-,74-,75-,76+,77+,78-,79+,80+,81+,87+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289109
(CHEMBL409339 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C92H105N21O22/c1-48-91(133)113-31-13-22-73(113)89(131)110-71(41-76(119)98-45-77(120)102-69(39-74(93)117)86(128)106-67(37-55-43-97-62-21-12-10-19-60(55)62)85(127)108-68(38-56-44-95-47-100-56)80(122)99-46-78(121)112-79(49(2)114)90(132)101-48)88(130)107-66(36-54-42-96-61-20-11-9-18-59(54)61)84(126)104-63(32-50-14-5-3-6-15-50)81(123)103-64(33-51-16-7-4-8-17-51)82(124)109-70(40-75(94)118)87(129)105-65(34-52-23-27-57(115)28-24-52)83(125)111-72(92(134)135)35-53-25-29-58(116)30-26-53/h3-12,14-21,23-30,42-44,47-49,63-73,79,96-97,114-116H,13,22,31-41,45-46H2,1-2H3,(H2,93,117)(H2,94,118)(H,95,100)(H,98,119)(H,99,122)(H,101,132)(H,102,120)(H,103,123)(H,104,126)(H,105,129)(H,106,128)(H,107,130)(H,108,127)(H,109,124)(H,110,131)(H,111,125)(H,112,121)(H,134,135)/t48-,49+,63-,64-,65-,66-,67-,68+,69+,70-,71+,72-,73+,79+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289116
(CHEMBL441573 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(46-86(132)110-51-87(133)114-79(44-84(104)130)97(142)119-77(41-61-48-108-70-24-13-10-21-67(61)70)96(141)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)99(144)120-76(40-60-47-107-69-23-12-9-20-66(60)69)95(140)117-72(36-56-16-5-3-6-17-56)91(136)115-73(37-57-18-7-4-8-19-57)93(138)122-80(45-85(105)131)98(143)118-74(38-58-27-31-64(128)32-28-58)92(137)116-75(39-59-29-33-65(129)34-30-59)94(139)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,132)(H,111,135)(H,113,146)(H,114,133)(H,115,136)(H,116,137)(H,117,140)(H,118,143)(H,119,142)(H,120,144)(H,121,141)(H,122,138)(H,123,145)(H,124,139)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75+,76-,77-,78+,79+,80-,81+,82-,83+,89+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >98 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289115
(CHEMBL410321 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(O)=O Show InChI InChI=1S/C94H108N22O23/c1-49-94(139)116-31-13-22-74(116)92(137)114-73(41-77(122)100-45-78(123)105-71(39-75(95)120)89(134)110-69(37-56-43-99-63-21-12-10-19-61(56)63)88(133)112-70(38-57-44-97-48-103-57)83(128)101-46-79(124)115-81(50(2)117)93(138)104-49)91(136)111-68(36-55-42-98-62-20-11-9-18-60(55)62)87(132)108-65(32-51-14-5-3-6-15-51)85(130)107-66(33-52-16-7-4-8-17-52)86(131)113-72(40-76(96)121)90(135)109-67(35-54-25-29-59(119)30-26-54)84(129)106-64(82(127)102-47-80(125)126)34-53-23-27-58(118)28-24-53/h3-12,14-21,23-30,42-44,48-50,64-74,81,98-99,117-119H,13,22,31-41,45-47H2,1-2H3,(H2,95,120)(H2,96,121)(H,97,103)(H,100,122)(H,101,128)(H,102,127)(H,104,138)(H,105,123)(H,106,129)(H,107,130)(H,108,132)(H,109,135)(H,110,134)(H,111,136)(H,112,133)(H,113,131)(H,114,137)(H,115,124)(H,125,126)/t49-,50+,64-,65-,66-,67-,68-,69-,70+,71+,72-,73+,74+,81+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289114
(CHEMBL409433 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C114H125N25O24/c1-60-113(161)139-39-17-30-93(139)111(159)136-91(51-96(145)122-57-97(146)126-89(49-94(115)143)108(156)132-86(45-67-53-119-78-27-14-10-23-74(67)78)106(154)134-88(48-70-56-117-59-124-70)100(148)123-58-98(147)138-99(61(2)140)112(160)125-60)110(158)133-85(44-66-52-118-77-26-13-9-22-73(66)77)105(153)129-81(40-62-18-5-3-6-19-62)101(149)127-82(41-63-20-7-4-8-21-63)104(152)135-90(50-95(116)144)109(157)130-83(42-64-31-35-71(141)36-32-64)102(150)128-84(43-65-33-37-72(142)38-34-65)103(151)131-87(46-68-54-120-79-28-15-11-24-75(68)79)107(155)137-92(114(162)163)47-69-55-121-80-29-16-12-25-76(69)80/h3-16,18-29,31-38,52-56,59-61,81-93,99,118-121,140-142H,17,30,39-51,57-58H2,1-2H3,(H2,115,143)(H2,116,144)(H,117,124)(H,122,145)(H,123,148)(H,125,160)(H,126,146)(H,127,149)(H,128,150)(H,129,153)(H,130,157)(H,131,151)(H,132,156)(H,133,158)(H,134,154)(H,135,152)(H,136,159)(H,137,155)(H,138,147)(H,162,163)/t60-,61+,81-,82-,83-,84-,85-,86-,87+,88+,89+,90-,91+,92-,93+,99+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289110
(CHEMBL414131 | RES-701-1-C-terminal analogue)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(O)=O Show InChI InChI=1S/C95H110N22O23/c1-49-94(138)117-32-14-23-75(117)92(136)115-74(42-78(123)101-46-79(124)106-72(40-76(96)121)89(133)111-70(38-57-44-100-64-22-13-11-20-62(57)64)88(132)113-71(39-58-45-98-48-103-58)82(126)102-47-80(125)116-81(51(3)118)93(137)104-49)91(135)112-69(37-56-43-99-63-21-12-10-19-61(56)63)87(131)109-66(33-52-15-6-4-7-16-52)84(128)108-67(34-53-17-8-5-9-18-53)86(130)114-73(41-77(97)122)90(134)110-68(36-55-26-30-60(120)31-27-55)85(129)107-65(83(127)105-50(2)95(139)140)35-54-24-28-59(119)29-25-54/h4-13,15-22,24-31,43-45,48-51,65-75,81,99-100,118-120H,14,23,32-42,46-47H2,1-3H3,(H2,96,121)(H2,97,122)(H,98,103)(H,101,123)(H,102,126)(H,104,137)(H,105,127)(H,106,124)(H,107,129)(H,108,128)(H,109,131)(H,110,134)(H,111,133)(H,112,135)(H,113,132)(H,114,130)(H,115,136)(H,116,125)(H,139,140)/t49-,50+,51+,65-,66-,67-,68-,69-,70-,71+,72+,73-,74+,75+,81+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity against Endothelin B receptor expressed from bovine cerebellum membrane preparation |
Bioorg Med Chem Lett 6: 775-778 (1996)
Article DOI: 10.1016/0960-894X(96)00127-8
BindingDB Entry DOI: 10.7270/Q2S182G7 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289656
(CHEMBL416287 | RES-701-1)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)C[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O)C(O)=O Show InChI InChI=1S/C41H53N13O13/c1-19-40(65)54-9-5-8-29(54)38(63)52-28(41(66)67)13-31(57)45-16-32(58)49-27(12-30(42)56)37(62)50-25(10-21-14-44-24-7-4-3-6-23(21)24)36(61)51-26(11-22-15-43-18-47-22)35(60)46-17-33(59)53-34(20(2)55)39(64)48-19/h3-4,6-7,14-15,18-20,25-29,34,44,55H,5,8-13,16-17H2,1-2H3,(H2,42,56)(H,43,47)(H,45,57)(H,46,60)(H,48,64)(H,49,58)(H,50,62)(H,51,61)(H,52,63)(H,53,59)(H,66,67)/t19-,20+,25-,26+,27+,28+,29+,34+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289653
(ENDOTHELIN | ET-1 | Endothelin 1 | Et 1)Show SMILES [H][C@]12CSSC[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N2)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)/t56-,57-,64+,66-,67-,68-,69+,70-,71-,72+,73-,74+,75-,76-,77+,78-,79+,80-,81-,82+,86-,87-,88-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289651
(CHEMBL407188 | Compound [S15]ET-1)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C65H89N13O15/c1-9-36(7)54(63(90)75-50(65(92)93)27-40-30-68-44-19-15-14-18-43(40)44)78-64(91)55(37(8)10-2)77-60(87)49(29-52(81)82)73-56(83)45(24-34(3)4)70-59(86)48(28-41-31-67-33-69-41)72-61(88)51(32-79)76-58(85)46(25-38-16-12-11-13-17-38)71-57(84)47(74-62(89)53(66)35(5)6)26-39-20-22-42(80)23-21-39/h11-23,30-31,33-37,45-51,53-55,68,79-80H,9-10,24-29,32,66H2,1-8H3,(H,67,69)(H,70,86)(H,71,84)(H,72,88)(H,73,83)(H,74,89)(H,75,90)(H,76,85)(H,77,87)(H,78,91)(H,81,82)(H,92,93)/t36-,37-,45-,46-,47-,48-,49-,50-,51-,53-,54-,55-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289654
(CHEMBL436894 | Compound SRTX6b)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C64H86N14O15S/c1-7-35(6)54(63(91)75-49(64(92)93)26-38-29-68-43-16-12-11-15-41(38)43)78-62(90)53(34(4)5)77-60(88)48(28-52(81)82)74-56(84)44(21-22-51(66)80)70-59(87)47(27-39-30-67-32-69-39)73-61(89)50(31-94)76-58(86)46(24-36-13-9-8-10-14-36)72-57(85)45(25-37-17-19-40(79)20-18-37)71-55(83)42(65)23-33(2)3/h8-20,29-30,32-35,42,44-50,53-54,68,79,94H,7,21-28,31,65H2,1-6H3,(H2,66,80)(H,67,69)(H,70,87)(H,71,83)(H,72,85)(H,73,89)(H,74,84)(H,75,91)(H,76,86)(H,77,88)(H,78,90)(H,81,82)(H,92,93)/t35-,42-,44-,45-,46-,47-,48-,49-,50-,53-,54-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289652
(CHEMBL437610 | Compound ET-3)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C65H89N13O15S/c1-9-35(7)54(63(90)75-50(65(92)93)26-39-29-68-44-14-12-11-13-43(39)44)78-64(91)55(36(8)10-2)77-60(87)49(28-52(81)82)73-56(83)45(23-33(3)4)70-59(86)48(27-40-30-67-32-69-40)72-61(88)51(31-94)76-58(85)46(24-37-15-19-41(79)20-16-37)71-57(84)47(74-62(89)53(66)34(5)6)25-38-17-21-42(80)22-18-38/h11-22,29-30,32-36,45-51,53-55,68,79-80,94H,9-10,23-28,31,66H2,1-8H3,(H,67,69)(H,70,86)(H,71,84)(H,72,88)(H,73,83)(H,74,89)(H,75,90)(H,76,85)(H,77,87)(H,78,91)(H,81,82)(H,92,93)/t35-,36-,45-,46-,47-,48-,49-,50-,51-,53-,54-,55-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289657
(CHEMBL414168 | RES-701-1)Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C62H64N10O11/c63-46(31-40-34-65-47-17-9-7-15-44(40)47)56(76)67-49(27-36-11-3-1-4-12-36)57(77)68-50(28-37-13-5-2-6-14-37)59(79)71-53(33-55(64)75)61(81)70-51(29-38-19-23-42(73)24-20-38)58(78)69-52(30-39-21-25-43(74)26-22-39)60(80)72-54(62(82)83)32-41-35-66-48-18-10-8-16-45(41)48/h1-26,34-35,46,49-54,65-66,73-74H,27-33,63H2,(H2,64,75)(H,67,76)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,80)(H,82,83)/t46-,49-,50-,51-,52-,53-,54-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289655
(CHEMBL414740 | N-C cyclized RES-70I-1)Show SMILES C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O Show InChI InChI=1S/C103H115N23O23/c1-54-103(149)126-35-15-26-83(126)101(147)124-82(46-88(134)135)100(146)121-77(41-61-48-108-70-24-13-10-21-67(61)70)96(142)117-72(36-56-16-5-3-6-17-56)92(138)115-73(37-57-18-7-4-8-19-57)95(141)123-81(45-85(105)131)99(145)118-74(38-58-27-31-64(128)32-28-58)93(139)116-75(39-59-29-33-65(129)34-30-59)94(140)119-76(40-60-47-107-69-23-12-9-20-66(60)69)90(136)110-51-86(132)114-80(44-84(104)130)98(144)120-78(42-62-49-109-71-25-14-11-22-68(62)71)97(143)122-79(43-63-50-106-53-112-63)91(137)111-52-87(133)125-89(55(2)127)102(148)113-54/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,137)(H,113,148)(H,114,132)(H,115,138)(H,116,139)(H,117,142)(H,118,145)(H,119,140)(H,120,144)(H,121,146)(H,122,143)(H,123,141)(H,124,147)(H,125,133)(H,134,135)/t54-,55+,72-,73+,74+,75-,76+,77+,78-,79+,80+,81-,82-,83+,89+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
Endothelin receptor type B
(Bos taurus) | BDBM50289649
(CHEMBL429908 | linear peptide of RES-701-1)Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)CN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C103H117N23O24/c1-54(113-101(147)89(55(2)127)125-87(133)52-111-90(136)78(43-63-51-107-53-112-63)121-96(142)77(41-61-49-109-70-24-13-10-21-67(61)70)119-97(143)79(44-84(105)130)114-86(132)47-104)102(148)126-35-15-26-83(126)100(146)123-81(46-88(134)135)99(145)120-76(40-60-48-108-69-23-12-9-20-66(60)69)95(141)117-72(36-56-16-5-3-6-17-56)91(137)115-73(37-57-18-7-4-8-19-57)93(139)122-80(45-85(106)131)98(144)118-74(38-58-27-31-64(128)32-28-58)92(138)116-75(39-59-29-33-65(129)34-30-59)94(140)124-82(103(149)150)42-62-50-110-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,48-51,53-55,72-83,89,108-110,127-129H,15,26,35-47,52,104H2,1-2H3,(H2,105,130)(H2,106,131)(H,107,112)(H,111,136)(H,113,147)(H,114,132)(H,115,137)(H,116,138)(H,117,141)(H,118,144)(H,119,143)(H,120,145)(H,121,142)(H,122,139)(H,123,146)(H,124,140)(H,125,133)(H,134,135)(H,149,150)/t54-,55+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,89-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding activity to ET-B receptor on bovine cerebellum membrane |
Bioorg Med Chem Lett 7: 1715-1720 (1997)
Article DOI: 10.1016/S0960-894X(97)00296-5
BindingDB Entry DOI: 10.7270/Q27081F2 |
More data for this
Ligand-Target Pair | |
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