Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrin alpha-M/beta-2 (Homo sapiens (Human)) | BDBM50462087 (CHEMBL4243248) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Inhibition of C3bi-AP binding to CR3 derived from human PMN | J Med Chem 61: 3253-3276 (2018) Article DOI: 10.1021/acs.jmedchem.7b00882 BindingDB Entry DOI: 10.7270/Q2MK6GJ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-M/beta-2 (Homo sapiens (Human)) | BDBM75309 ((2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Inhibition of C3bi-AP binding to CR3 derived from human PMN | J Med Chem 61: 3253-3276 (2018) Article DOI: 10.1021/acs.jmedchem.7b00882 BindingDB Entry DOI: 10.7270/Q2MK6GJ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-M/beta-2 (Homo sapiens (Human)) | BDBM50462087 (CHEMBL4243248) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Antagonist activity at CR3 in carboxyfluorescein diacetate succiminidyl ester-labeled human PMN assessed as inhibition of TNF/PMA-stimulated adhesion... | J Med Chem 61: 3253-3276 (2018) Article DOI: 10.1021/acs.jmedchem.7b00882 BindingDB Entry DOI: 10.7270/Q2MK6GJ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-M/beta-2 (Homo sapiens (Human)) | BDBM75309 ((2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Antagonist activity at CR3 in carboxyfluorescein diacetate succiminidyl ester-labeled human PMN assessed as inhibition of TNF/PMA-stimulated adhesion... | J Med Chem 61: 3253-3276 (2018) Article DOI: 10.1021/acs.jmedchem.7b00882 BindingDB Entry DOI: 10.7270/Q2MK6GJ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-M/beta-2 (Homo sapiens (Human)) | BDBM50055896 (3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of Mac-1 interaction with ICAM | J Med Chem 40: 50-60 (1997) Article DOI: 10.1021/jm960626t BindingDB Entry DOI: 10.7270/Q2HD7TRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-M/beta-2 (Homo sapiens (Human)) | BDBM50055896 (3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of Mac-1 integrin (alphaM-beta2) | J Med Chem 40: 50-60 (1997) Article DOI: 10.1021/jm960626t BindingDB Entry DOI: 10.7270/Q2HD7TRV | |||||||||||
More data for this Ligand-Target Pair |