Found 12 hits of ic50 for UniProtKB: P22459 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50279106
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456976
(CHEMBL4207745)Show SMILES Nc1nc(\C=C\CNC(=O)c2cc(Cl)c(Cl)[nH]2)c[nH]1 Show InChI InChI=1S/C11H11Cl2N5O/c12-7-4-8(18-9(7)13)10(19)15-3-1-2-6-5-16-11(14)17-6/h1-2,4-5,18H,3H2,(H,15,19)(H3,14,16,17)/b2-1+ | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50220547
(4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-ami...)Show SMILES Nc1ncc(C=CCNC(=O)c2cc(Br)c(Br)[nH]2)[nH]1 |w:6.6| Show InChI InChI=1S/C11H11Br2N5O/c12-7-4-8(18-9(7)13)10(19)15-3-1-2-6-5-16-11(14)17-6/h1-2,4-5,18H,3H2,(H,15,19)(H3,14,16,17) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456974
(CHEMBL3621636)Show InChI InChI=1S/C11H12BrN5O/c12-7-4-9(15-5-7)10(18)14-3-1-2-8-6-16-11(13)17-8/h1-2,4-6,15H,3H2,(H,14,18)(H3,13,16,17)/b2-1+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456970
(CHEMBL3261431)Show SMILES Nc1nc(\C=C\CNC(=O)c2cc3cc(F)ccc3[nH]2)c[nH]1 Show InChI InChI=1S/C15H14FN5O/c16-10-3-4-12-9(6-10)7-13(21-12)14(22)18-5-1-2-11-8-19-15(17)20-11/h1-4,6-8,21H,5H2,(H,18,22)(H3,17,19,20)/b2-1+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456975
(CHEMBL4213446)Show InChI InChI=1S/C12H14BrN5O/c1-7-9(13)5-10(17-7)11(19)15-4-2-3-8-6-16-12(14)18-8/h2-3,5-6,17H,4H2,1H3,(H,15,19)(H3,14,16,18)/b3-2+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456982
(CHEMBL4208517)Show SMILES Cc1[nH]c(C(=O)NC\C=C\c2c[nH]c(N)n2)c(Br)c1Br Show InChI InChI=1S/C12H13Br2N5O/c1-6-8(13)9(14)10(18-6)11(20)16-4-2-3-7-5-17-12(15)19-7/h2-3,5,18H,4H2,1H3,(H,16,20)(H3,15,17,19)/b3-2+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456977
(CHEMBL3261430)Show InChI InChI=1S/C15H15N5O/c16-15-18-9-11(19-15)5-3-7-17-14(21)13-8-10-4-1-2-6-12(10)20-13/h1-6,8-9,20H,7H2,(H,17,21)(H3,16,18,19)/b5-3+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456969
(CHEMBL4202870)Show InChI InChI=1S/C12H14ClN5O/c1-7-9(13)5-10(17-7)11(19)15-4-2-3-8-6-16-12(14)18-8/h2-3,5-6,17H,4H2,1H3,(H,15,19)(H3,14,16,18)/b3-2+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456971
(CHEMBL4210636)Show SMILES Nc1nc(\C=C\CNC(=O)c2cc3cc(Cl)ccc3[nH]2)c[nH]1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-4-12-9(6-10)7-13(21-12)14(22)18-5-1-2-11-8-19-15(17)20-11/h1-4,6-8,21H,5H2,(H,18,22)(H3,17,19,20)/b2-1+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50237157
(CHEMBL4079366)Show SMILES Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 Show InChI InChI=1S/C29H34N6O2/c1-19-3-7-21(8-4-19)29(22-9-5-20(2)6-10-22,25-13-11-23(34-25)27(36)32-17-15-30)26-14-12-24(35-26)28(37)33-18-16-31/h3-14,34-35H,15-18,30-31H2,1-2H3,(H,32,36)(H,33,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dublin Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of Kv1.4 (unknown origin) expressed in HEK293 cells by whole cell patch clamp Qpatch method |
J Med Chem 60: 2245-2256 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 4
(Homo sapiens (Human)) | BDBM50456973
(Clathrodin)Show InChI InChI=1S/C11H13N5O/c12-11-15-7-8(16-11)3-1-6-14-10(17)9-4-2-5-13-9/h1-5,7,13H,6H2,(H,14,17)(H3,12,15,16)/b3-1+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method |
Eur J Med Chem 139: 232-241 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4 |
More data for this Ligand-Target Pair | |