Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM50535044 (CHEMBL4471567) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assay | ACS Med Chem Lett 7: 780-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00169 BindingDB Entry DOI: 10.7270/Q2CV4N75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM426060 (US10513520, Compound 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a |
Regents of the University of Minnesota US Patent | Assay Description ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ... | US Patent US10513520 (2019) BindingDB Entry DOI: 10.7270/Q2VD71VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM50119454 (CHEMBL3140272) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assay | ACS Med Chem Lett 7: 780-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00169 BindingDB Entry DOI: 10.7270/Q2CV4N75 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM426057 (US10513520, Compound 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a |
Regents of the University of Minnesota US Patent | Assay Description ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ... | US Patent US10513520 (2019) BindingDB Entry DOI: 10.7270/Q2VD71VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM50535045 (CHEMBL4455776) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assay | ACS Med Chem Lett 7: 780-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00169 BindingDB Entry DOI: 10.7270/Q2CV4N75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM426059 (US10513520, Compound 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a |
Regents of the University of Minnesota US Patent | Assay Description ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ... | US Patent US10513520 (2019) BindingDB Entry DOI: 10.7270/Q2VD71VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM50535046 (CHEMBL4549820) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assay | ACS Med Chem Lett 7: 780-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00169 BindingDB Entry DOI: 10.7270/Q2CV4N75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM426058 (US10513520, Compound 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a |
Regents of the University of Minnesota US Patent | Assay Description ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ... | US Patent US10513520 (2019) BindingDB Entry DOI: 10.7270/Q2VD71VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM50535047 (CHEMBL4468179) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity to His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells by isothermal titration calorimetric assay | ACS Med Chem Lett 7: 780-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00169 BindingDB Entry DOI: 10.7270/Q2CV4N75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM426056 (US10513520, Compound 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 3.65E+3 | n/a | n/a | n/a | n/a | n/a |
Regents of the University of Minnesota US Patent | Assay Description ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ... | US Patent US10513520 (2019) BindingDB Entry DOI: 10.7270/Q2VD71VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM50360481 (CHEMBL1934757) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.65E+3 | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Binding affinity to recombinant human HINT1 by isothermal titration calorimetric assay | ACS Med Chem Lett 7: 780-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00169 BindingDB Entry DOI: 10.7270/Q2CV4N75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine 5'-monophosphoramidase HINT1 (Homo sapiens (Human)) | BDBM426061 (US10513520, Compound GMP | guanosine monophosphate) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a |
Regents of the University of Minnesota US Patent | Assay Description ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ... | US Patent US10513520 (2019) BindingDB Entry DOI: 10.7270/Q2VD71VS | |||||||||||
More data for this Ligand-Target Pair |