BindingDB PrimarySearch

Found 5 hits of ec50 for UniProtKB: P40145
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Adenylate cyclase type 1/2/3/4/5/6/7/8/9 (Homo sapiens (Human))	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
University of Lund Curated by ChEMBL					Assay Description Compound was tested for the adenylate cyclase stimulation				J Med Chem 35: 502-7 (1992) BindingDB Entry DOI: 10.7270/Q2TH8N95
University of Lund Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50010261 ((3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	94	n/a	n/a	n/a	n/a
Kunming Medical University Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit m...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126823 BindingDB Entry DOI: 10.7270/Q2Q52T4B
Kunming Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50537925 (CHEMBL4644318) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	105	n/a	n/a	n/a	n/a
Kunming Medical University Curated by ChEMBL					Assay Description Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit m...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126823 BindingDB Entry DOI: 10.7270/Q2Q52T4B
Kunming Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 1/2/3/4/5/6/7/8/9 (Homo sapiens (Human))	BDBM50004821 (2,3,4,5-Tetrahydro-1H-benzo[d]azepine-7,8-diol \| C...) Show SMILES Oc1cc2CCNCCc2cc1O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a
University of Lund Curated by ChEMBL					Assay Description Compound was tested for the adenylate cyclase stimulation				J Med Chem 35: 502-7 (1992) BindingDB Entry DOI: 10.7270/Q2TH8N95
University of Lund Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 1/2/3/4/5/6/7/8/9 (Homo sapiens (Human))	BDBM50230364 (CHEMBL146629) Show SMILES [H][C@@]1(CNCCc2cc(O)c(O)cc12)C1CCCCC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Lund Curated by ChEMBL					Assay Description Compound was tested for the adenylate cyclase stimulation				J Med Chem 35: 502-7 (1992) BindingDB Entry DOI: 10.7270/Q2TH8N95
University of Lund Curated by ChEMBL					More data for this Ligand-Target Pair