Compile Data Set for Download or QSAR

Found 6 hits of ic50 for UniProtKB: P10499   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily A member 1 (Rattus norvegicus)	BDBM50237249 (CHEMBL4076021) Show SMILES CC(C)(C)OC(=O)NCCNC(=O)c1ccc(cc1)-c1c2ccc(n2)c(-c2ccc(cc2)C(=O)NCCNC(=O)OC(C)(C)C)c2ccc([nH]2)c(-c2ccc(cc2)C(=O)NCCNC(=O)OC(C)(C)C)c2ccc(n2)c(-c2ccc(cc2)C(=O)NCCNC(=O)OC(C)(C)C)c2ccc1[nH]2 Show InChI InChI=1S/C76H86N12O12/c1-73(2,3)97-69(93)81-41-37-77-65(89)49-21-13-45(14-22-49)61-53-29-31-55(85-53)62(46-15-23-50(24-16-46)66(90)78-38-42-82-70(94)98-74(4,5)6)57-33-35-59(87-57)64(48-19-27-52(28-20-48)68(92)80-40-44-84-72(96)100-76(10,11)12)60-36-34-58(88-60)63(56-32-30-54(61)86-56)47-17-25-51(26-18-47)67(91)79-39-43-83-71(95)99-75(7,8)9/h13-36,85,88H,37-44H2,1-12H3,(H,77,89)(H,78,90)(H,79,91)(H,80,92)(H,81,93)(H,82,94)(H,83,95)(H,84,96)/b61-53-,61-54-,62-55-,62-57-,63-56-,63-58-,64-59-,64-60-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant rat Kv1.1 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 1 (Rattus norvegicus)	BDBM50237157 (CHEMBL4079366) Show SMILES Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 Show InChI InChI=1S/C29H34N6O2/c1-19-3-7-21(8-4-19)29(22-9-5-20(2)6-10-22,25-13-11-23(34-25)27(36)32-17-15-30)26-14-12-24(35-26)28(37)33-18-16-31/h3-14,34-35H,15-18,30-31H2,1-2H3,(H,32,36)(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant rat Kv(1.1)4 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 1 (Rattus norvegicus)	BDBM50237157 (CHEMBL4079366) Show SMILES Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 Show InChI InChI=1S/C29H34N6O2/c1-19-3-7-21(8-4-19)29(22-9-5-20(2)6-10-22,25-13-11-23(34-25)27(36)32-17-15-30)26-14-12-24(35-26)28(37)33-18-16-31/h3-14,34-35H,15-18,30-31H2,1-2H3,(H,32,36)(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant rat Kv1.1 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 1/2 (Rattus norvegicus)	BDBM50237157 (CHEMBL4079366) Show SMILES Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 Show InChI InChI=1S/C29H34N6O2/c1-19-3-7-21(8-4-19)29(22-9-5-20(2)6-10-22,25-13-11-23(34-25)27(36)32-17-15-30)26-14-12-24(35-26)28(37)33-18-16-31/h3-14,34-35H,15-18,30-31H2,1-2H3,(H,32,36)(H,33,37)	PDB MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant rat Kv(1.1)3/Kv1.2 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 1/2 (Rattus norvegicus)	BDBM50237157 (CHEMBL4079366) Show SMILES Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 Show InChI InChI=1S/C29H34N6O2/c1-19-3-7-21(8-4-19)29(22-9-5-20(2)6-10-22,25-13-11-23(34-25)27(36)32-17-15-30)26-14-12-24(35-26)28(37)33-18-16-31/h3-14,34-35H,15-18,30-31H2,1-2H3,(H,32,36)(H,33,37)	PDB MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant rat Kv(1.1)2/Kv(1.2)2 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 1/2 (Rattus norvegicus)	BDBM50237157 (CHEMBL4079366) Show SMILES Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 Show InChI InChI=1S/C29H34N6O2/c1-19-3-7-21(8-4-19)29(22-9-5-20(2)6-10-22,25-13-11-23(34-25)27(36)32-17-15-30)26-14-12-24(35-26)28(37)33-18-16-31/h3-14,34-35H,15-18,30-31H2,1-2H3,(H,32,36)(H,33,37)	PDB MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant rat Kv1.1/Kv(1.2)3 expressed in HEK293 cells at -90 mV holding potential by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
					More data for this Ligand-Target Pair