Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM26621 (4-[dihydroxy(oxo)--stibanyl]-2-nitrobenzoic acid |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | 19 | -10.4 | 4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Johns Hopkins University | Assay Description The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w... | Mol Pharmacol 73: 669-77 (2008) Article DOI: 10.1124/mol.107.042622 BindingDB Entry DOI: 10.7270/Q2WS8RJX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM26622 (Compound 13793 | ethyl 4-{4-[dihydroxy(oxo)--stiba...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | 36 | -10.0 | 17 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Johns Hopkins University | Assay Description The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w... | Mol Pharmacol 73: 669-77 (2008) Article DOI: 10.1124/mol.107.042622 BindingDB Entry DOI: 10.7270/Q2WS8RJX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92732 (NSC332395, 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318446 (NSC332395 | US9624235, Compound 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318443 (NSC332398 | US9624235, Compound 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92729 (NSC332398, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92731 (NSC332389, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318445 (NSC332389 | US9624235, Compound 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318444 (NSC332384 | US9624235, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92730 (NSC332384, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318448 (NSC332397 | US9624235, Compound 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92733 (NSC332396, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318447 (NSC332396 | US9624235, Compound 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318454 (NSC614430 | US9624235, Compound 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92740 (NSC614430, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318452 (NSC131534 | US9624235, Compound 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92738 (NSC131534, 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318449 (NSC300598 | US9624235, Compound 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92735 (NSC300598, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92736 (NSC89640, 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318450 (NSC89640 | US9624235, Compound 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318451 (NSC107215 | US9624235, Compound 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92737 (NSC107215, 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92739 (NSC375491, 12 | US9624235, Compound 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92739 (NSC375491, 12 | US9624235, Compound 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM92741 (NSC402686, 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh | Assay Description A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described. | Biochemistry 51: 6246-59 (2012) Article DOI: 10.1021/bi300490r BindingDB Entry DOI: 10.7270/Q2D7991B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-(apurinic or apyrimidinic site) endonuclease (Homo sapiens (Human)) | BDBM318455 (NSC402686 | US9624235, Compound 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent | Assay Description The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ... | US Patent US9624235 (2017) BindingDB Entry DOI: 10.7270/Q2SQ92GH | |||||||||||
More data for this Ligand-Target Pair |