Compile Data Set for Download or QSAR

Found 699 hits of ic50 for UniProtKB: O60885   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480649 (US10899769, Example 44b) Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1noc(=O)[nH]1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480561 (US10899769, Example 45a) Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3noc(=O)[nH]3)c(cc12)C(F)F |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480490 (US10899769, Example 3 | US10899769, Example 49) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C25H28F2N6O/c1-14-25(34)30(2)13-21-24(29-23(33(14)21)15-6-7-15)32-8-4-5-16-9-18(17-11-28-31(3)12-17)19(22(26)27)10-20(16)32/h9-12,14-15,22H,4-8,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480572 (5-(3-cyclopropyl-5,7- dimethyl-6-oxo-5,6,7,8- tetr...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C#N Show InChI InChI=1S/C25H23N7O/c1-14-25(33)30(2)13-21-23(29-24(32(14)21)15-7-8-15)18-5-4-6-20-19(18)9-16(10-26)22(28-20)17-11-27-31(3)12-17/h4-6,9,11-12,14-15H,7-8,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480580 (3-cyclopropyl-1-(3-(1,3- dimethyl-1H-pyrazol-4- yl...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cn(C)nc1C Show InChI InChI=1S/C25H26N6O/c1-14-20(12-30(4)28-14)21-10-17-6-5-7-18(19(17)11-26-21)23-22-13-29(3)25(32)15(2)31(22)24(27-23)16-8-9-16/h5-7,10-12,15-16H,8-9,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480603 (5,7-dimethyl-1-(3-(1- methyl-1H-pyrazol-3- yl)isoq...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-c1ccn(C)n1 Show InChI InChI=1S/C26H28N6O2/c1-16-26(33)30(2)15-23-24(28-25(32(16)23)17-8-11-34-12-9-17)19-6-4-5-18-13-22(27-14-20(18)19)21-7-10-31(3)29-21/h4-7,10,13-14,16-17H,8-9,11-12,15H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480553 (US10899769, Example 37a) Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1cnc(C)s1 |r,wD:1.0,(8.86,-2.42,;8.86,-.88,;10.2,-.11,;11.53,-.88,;10.2,1.43,;11.53,2.2,;8.86,2.2,;7.53,1.43,;6.06,1.9,;5.16,.66,;6.06,-.59,;5.59,-2.06,;6.62,-3.2,;6.14,-4.66,;4.64,-4.98,;3.61,-3.84,;4.08,-2.38,;7.53,-.11,;5.59,3.37,;4.08,3.69,;3.05,2.54,;3.61,5.15,;4.64,6.29,;6.14,5.97,;7.17,7.12,;8.68,6.8,;9.16,5.33,;8.13,4.19,;6.62,4.51,;9.71,7.94,;9.39,9.45,;10.72,10.22,;11.87,9.19,;13.37,9.51,;11.24,7.78,)| Show InChI InChI=1S/C26H26FN5O2S/c1-14-26(33)31(3)13-21-24(30-25(32(14)21)16-6-8-34-9-7-16)23-18-11-29-20(22-12-28-15(2)35-22)10-17(18)4-5-19(23)27/h4-5,10-12,14,16H,6-9,13H2,1-3H3/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480607 ((R)-1-(3-(difluoromethyl)- 2-(1-methyl-1H-pyrazol-...) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2nc(-c3ccn(C)n3)c(cc12)C(F)F |r| Show InChI InChI=1S/C27H28F2N6O2/c1-15-27(36)33(2)14-22-24(31-26(35(15)22)16-8-11-37-12-9-16)17-5-4-6-20-18(17)13-19(25(28)29)23(30-20)21-7-10-34(3)32-21/h4-7,10,13,15-16,25H,8-9,11-12,14H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480632 ((R)-3-cyclopropyl-1-(3 (difluoromethyl)-2-(1- met...) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)F |r| Show InChI InChI=1S/C25H24F2N6O/c1-13-25(34)31(2)12-20-22(30-24(33(13)20)14-7-8-14)16-5-4-6-19-17(16)9-18(23(26)27)21(29-19)15-10-28-32(3)11-15/h4-6,9-11,13-14,23H,7-8,12H2,1-3H3/t13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480634 ((R)-3-cyclopropyl-5,7- dimethyl-1-(3-(1-methyl- 1H...) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C24H24N6O/c1-14-24(31)28(2)13-21-22(27-23(30(14)21)15-7-8-15)18-6-4-5-16-9-20(25-11-19(16)18)17-10-26-29(3)12-17/h4-6,9-12,14-15H,7-8,13H2,1-3H3/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480490 (US10899769, Example 3 | US10899769, Example 49) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C25H28F2N6O/c1-14-25(34)30(2)13-21-24(29-23(33(14)21)15-6-7-15)32-8-4-5-16-9-18(17-11-28-31(3)12-17)19(22(26)27)10-20(16)32/h9-12,14-15,22H,4-8,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480546 (US10899769, Example 30a) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-n1cnc(C)c1 |r| Show InChI InChI=1S/C26H28N6O2/c1-16-13-31(15-28-16)23-11-19-5-4-6-20(21(19)12-27-23)24-22-14-30(3)26(33)17(2)32(22)25(29-24)18-7-9-34-10-8-18/h4-6,11-13,15,17-18H,7-10,14H2,1-3H3/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480605 (1-(3-(1,3-dimethyl-1H- pyrazol-4-yl)isoquinolin-8-...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-c1cn(C)nc1C Show InChI InChI=1S/C27H30N6O2/c1-16-22(14-32(4)30-16)23-12-19-6-5-7-20(21(19)13-28-23)25-24-15-31(3)27(34)17(2)33(24)26(29-25)18-8-10-35-11-9-18/h5-7,12-14,17-18H,8-11,15H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480562 (3-(5-(3-Cyclopropyl-5,7-dimethyl-6-oxo-5,6,7,8-tet...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3nsc(=O)[nH]3)c(cc12)C(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480552 (US10899769, Example 36a) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2nc(-c3cnn(C)c3)c(cc12)C(F)F |r,wU:1.0,(7.53,-.11,;7.53,1.43,;8.86,2.2,;10.2,1.43,;8.86,3.74,;10.2,4.51,;7.53,4.51,;6.2,3.74,;4.73,4.21,;3.83,2.97,;4.73,1.72,;4.25,.25,;5.29,-.89,;4.81,-2.35,;3.3,-2.67,;2.27,-1.53,;2.75,-.07,;6.2,2.2,;4.25,5.68,;5.29,6.82,;6.79,6.5,;4.81,8.28,;3.3,8.6,;2.27,7.46,;.77,7.78,;-.26,6.64,;-1.77,6.96,;-2.91,5.93,;-4.25,6.7,;-3.93,8.2,;-4.96,9.35,;-2.4,8.36,;.21,5.17,;1.72,4.85,;2.75,6,;-.82,4.03,;-.34,2.56,;-2.33,4.35,)| Show InChI InChI=1S/C27H27F3N6O2/c1-14-27(37)34(2)13-21-24(33-26(36(14)21)15-6-8-38-9-7-15)22-17-10-18(25(29)30)23(16-11-31-35(3)12-16)32-20(17)5-4-19(22)28/h4-5,10-12,14-15,25H,6-9,13H2,1-3H3/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480563 (3-(8-(3-Cyclopropyl-5,7-dimethyl-6-oxo-5,6,7,8-tet...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1nsc(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480571 (3-cyclopropyl-l-(3-(3,6- dihydro-2H-pyran-4- yl)is...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)C1=CCOCC1 |t:30| Show InChI InChI=1S/C25H26N4O2/c1-15-25(30)28(2)14-22-23(27-24(29(15)22)17-6-7-17)19-5-3-4-18-12-21(26-13-20(18)19)16-8-10-31-11-9-16/h3-5,8,12-13,15,17H,6-7,9-11,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480575 (3-cyclopropyl-5,7- dimethyl-1-(3-(tetrahydro- 2H-p...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)C1CCOCC1 Show InChI InChI=1S/C25H28N4O2/c1-15-25(30)28(2)14-22-23(27-24(29(15)22)17-6-7-17)19-5-3-4-18-12-21(26-13-20(18)19)16-8-10-31-11-9-16/h3-5,12-13,15-17H,6-11,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480577 (3-cyclopropyl-1-(3- (difluoromethyl)-2-(1 methyl-...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C25H24F2N6O/c1-13-25(34)31(2)12-20-22(30-24(33(13)20)14-7-8-14)16-5-4-6-19-17(16)9-18(23(26)27)21(29-19)15-10-28-32(3)11-15/h4-6,9-11,13-14,23H,7-8,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480579 (3-cyclopropyl-5,7- dimethyl-1-(3-(l-methyl- 1H-pyr...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1ccn(C)n1 Show InChI InChI=1S/C24H24N6O/c1-14-24(31)28(2)13-21-22(26-23(30(14)21)15-7-8-15)17-6-4-5-16-11-20(25-12-18(16)17)19-9-10-29(3)27-19/h4-6,9-12,14-15H,7-8,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480588 (3-cyclopropyl-5,7- dimethyl-1-(3-(4-methyl- 1H-imi...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-n1cnc(C)c1 Show InChI InChI=1S/C24H24N6O/c1-14-11-29(13-26-14)21-9-17-5-4-6-18(19(17)10-25-21)22-20-12-28(3)24(31)15(2)30(20)23(27-22)16-7-8-16/h4-6,9-11,13,15-16H,7-8,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480590 (3-cyclopropyl-1-(3-(3,4- dimethyl-1H-pyrazol-1- yl...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-n1cc(C)c(C)n1 Show InChI InChI=1S/C25H26N6O/c1-14-12-30(28-15(14)2)22-10-18-6-5-7-19(20(18)11-26-22)23-21-13-29(4)25(32)16(3)31(21)24(27-23)17-8-9-17/h5-7,10-12,16-17H,8-9,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480594 (3-cyclopropyl-5,7- dimethyl-1-(3-(1-methyl- 1H-imi...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cn(C)cn1 Show InChI InChI=1S/C24H24N6O/c1-14-24(31)29(3)12-21-22(27-23(30(14)21)15-7-8-15)17-6-4-5-16-9-19(25-10-18(16)17)20-11-28(2)13-26-20/h4-6,9-11,13-15H,7-8,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480630 (5,7-dimethyl-1-(3-(1- methyl-1H-pyrazol-4- yl)isoq...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-c1cnn(C)c1 Show InChI InChI=1S/C26H28N6O2/c1-16-26(33)30(2)15-23-24(29-25(32(16)23)17-7-9-34-10-8-17)20-6-4-5-18-11-22(27-13-21(18)20)19-12-28-31(3)14-19/h4-6,11-14,16-17H,7-10,15H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480636 (US10899769, Example 8b) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C#N |r| Show InChI InChI=1S/C27H27N7O2/c1-16-27(35)32(2)15-23-25(31-26(34(16)23)17-7-9-36-10-8-17)20-5-4-6-22-21(20)11-18(12-28)24(30-22)19-13-29-33(3)14-19/h4-6,11,13-14,16-17H,7-10,15H2,1-3H3/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480526 (3-Cyclopropyl-1-(3-(difluoromethyl)-2-(tetrahydro-...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(C3CCOCC3)c(cc12)C(F)F Show InChI InChI=1S/C26H28F2N4O2/c1-14-26(33)31(2)13-21-23(30-25(32(14)21)16-6-7-16)17-4-3-5-20-18(17)12-19(24(27)28)22(29-20)15-8-10-34-11-9-15/h3-5,12,14-16,24H,6-11,13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480529 (3-Cyclopropyl-5,7-dimethyl-1-(3-(2-methylthiazol-5...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cnc(C)s1 Show InChI InChI=1S/C24H23N5OS/c1-13-24(30)28(3)12-20-22(27-23(29(13)20)15-7-8-15)17-6-4-5-16-9-19(26-10-18(16)17)21-11-25-14(2)31-21/h4-6,9-11,13,15H,7-8,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480637 (US10899769, Example 15b) Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)C1CCOCC1 |r| Show InChI InChI=1S/C27H32N4O3/c1-17-27(32)30(2)16-24-25(29-26(31(17)24)19-8-12-34-13-9-19)21-5-3-4-20-14-23(28-15-22(20)21)18-6-10-33-11-7-18/h3-5,14-15,17-19H,6-13,16H2,1-2H3/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480533 (1-(3-(2H-Tetrazol-5-yl)isoquinolin-8-yl)-3-cyclopr...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1nn[nH]n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480542 (US10899769, Example 26a) Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)(F)F |r| Show InChI InChI=1S/C27H27F3N6O2/c1-15-26(37)34(2)14-22-24(33-25(36(15)22)16-7-9-38-10-8-16)18-5-4-6-21-19(18)11-20(27(28,29)30)23(32-21)17-12-31-35(3)13-17/h4-6,11-13,15-16H,7-10,14H2,1-3H3/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480642 (US10899769, Example 31b) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-c1cnc(C)s1 |r| Show InChI InChI=1S/C26H27N5O2S/c1-15-26(32)30(3)14-22-24(29-25(31(15)22)17-7-9-33-10-8-17)19-6-4-5-18-11-21(28-12-20(18)19)23-13-27-16(2)34-23/h4-6,11-13,15,17H,7-10,14H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480643 (US10899769, Example 32b) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(n12)C1(C)CCOCC1)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)F |r| Show InChI InChI=1S/C28H30F2N6O2/c1-16-26(37)34(3)15-22-24(33-27(36(16)22)28(2)8-10-38-11-9-28)18-6-5-7-21-19(18)12-20(25(29)30)23(32-21)17-13-31-35(4)14-17/h5-7,12-14,16,25H,8-11,15H2,1-4H3/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM570184 (US11427593, Compound ZB-BD-202) Show SMILES Cc1cc(-c2cc(CS(C)(=O)=O)cnc2OC2CCCCC2)n2cc[nH]c(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen kit (Perkin Elmer) was used to detect effect of the compounds on binding of BRD4 bromodomain to acetylated histone H4 polypeptide. The br...				Citation and Details BindingDB Entry DOI: 10.7270/Q2N3016N
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480585 (3-cyclopropyl-1-(3- (difluoromethyl)-2-(3- methyl-...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(c(cc12)C(F)F)-n1cnc(C)n1 Show InChI InChI=1S/C24H23F2N7O/c1-12-24(34)31(3)10-19-20(29-22(33(12)19)14-7-8-14)15-5-4-6-18-16(15)9-17(21(25)26)23(28-18)32-11-27-13(2)30-32/h4-6,9,11-12,14,21H,7-8,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480591 (3-cyclopropyl-5,7- dimethyl-1-(3-(3-methyl- 1H-pyr...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-n1ccc(C)n1 Show InChI InChI=1S/C24H24N6O/c1-14-9-10-29(27-14)21-11-17-5-4-6-18(19(17)12-25-21)22-20-13-28(3)24(31)15(2)30(20)23(26-22)16-7-8-16/h4-6,9-12,15-16H,7-8,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480611 (1-(3-(1,3-dimethyl-1H- pyrazol-4-yl)-7- fluoroisoq...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1cn(C)nc1C |(.6,5.86,;.13,4.39,;-1.38,4.07,;-2.41,5.21,;-1.86,2.61,;-3.34,2.21,;-.82,1.46,;.68,1.78,;1.93,.88,;3.17,1.78,;2.7,3.25,;3.47,4.58,;5.01,4.58,;5.78,5.91,;5.01,7.25,;3.47,7.25,;2.7,5.91,;1.16,3.25,;1.93,-.66,;3.26,-1.43,;4.59,-.66,;3.26,-2.97,;1.93,-3.74,;.59,-2.97,;-.74,-3.74,;-2.07,-2.97,;-2.07,-1.43,;-.74,-.66,;.59,-1.43,;-3.41,-3.74,;-3.41,-5.28,;-4.87,-5.76,;-5.27,-7.25,;-5.78,-4.51,;-4.87,-3.27,;-5.27,-1.78,)| Show InChI InChI=1S/C27H29FN6O2/c1-15-20(13-33(4)31-15)22-11-18-5-6-21(28)24(19(18)12-29-22)25-23-14-32(3)27(35)16(2)34(23)26(30-25)17-7-9-36-10-8-17/h5-6,11-13,16-17H,7-10,14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480638 (US10899769, Example 16b) Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)N1CCOCC1 |r| Show InChI InChI=1S/C26H31N5O3/c1-17-26(32)29(2)16-22-24(28-25(31(17)22)18-6-10-33-11-7-18)20-5-3-4-19-14-23(27-15-21(19)20)30-8-12-34-13-9-30/h3-5,14-15,17-18H,6-13,16H2,1-2H3/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480528 (3-cyclopropyl-1-(3-(difluoromethyl)-2-(4-methyl-1H...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(c(cc12)C(F)F)-n1cc(C)nn1 Show InChI InChI=1S/C24H23F2N7O/c1-12-10-32(30-29-12)23-17(21(25)26)9-16-15(5-4-6-18(16)27-23)20-19-11-31(3)24(34)13(2)33(19)22(28-20)14-7-8-14/h4-6,9-10,13-14,21H,7-8,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480530 (3-Cyclopropyl-5,7-dimethyl-1-(3-(4-methyl-1H-pyraz...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-n1cc(C)cn1 Show InChI InChI=1S/C24H24N6O/c1-14-10-26-29(12-14)21-9-17-5-4-6-18(19(17)11-25-21)22-20-13-28(3)24(31)15(2)30(20)23(27-22)16-7-8-16/h4-6,9-12,15-16H,7-8,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480525 (3-Cyclopropyl-1-(3-(difluoromethyl)-2-(3,6-dihydro...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(C3=CCOCC3)c(cc12)C(F)F |t:25| Show InChI InChI=1S/C26H26F2N4O2/c1-14-26(33)31(2)13-21-23(30-25(32(14)21)16-6-7-16)17-4-3-5-20-18(17)12-19(24(27)28)22(29-20)15-8-10-34-11-9-15/h3-5,8,12,14,16,24H,6-7,9-11,13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480589 (3-cyclopropyl-5,7- dimethyl-1-(3-(3-methyl- 1H-1,2...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-n1cnc(C)n1 Show InChI InChI=1S/C23H23N7O/c1-13-23(31)28(3)11-19-21(26-22(30(13)19)15-7-8-15)17-6-4-5-16-9-20(24-10-18(16)17)29-12-25-14(2)27-29/h4-6,9-10,12-13,15H,7-8,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480576 (3-cyclopropyl-1- (3-(1,5- dimethyl-1H-pyrazol-4- y...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3C)c(cc12)C#N Show InChI InChI=1S/C26H25N7O/c1-14-20(12-28-32(14)4)23-17(11-27)10-19-18(6-5-7-21(19)29-23)24-22-13-31(3)26(34)15(2)33(22)25(30-24)16-8-9-16/h5-7,10,12,15-16H,8-9,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480578 (3-cyclopropyl-1-(3- (difluoromethyl)-2-(1,5- dime...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3C)c(cc12)C(F)F Show InChI InChI=1S/C26H26F2N6O/c1-13-19(11-29-33(13)4)22-18(24(27)28)10-17-16(6-5-7-20(17)30-22)23-21-12-32(3)26(35)14(2)34(21)25(31-23)15-8-9-15/h5-7,10-11,14-15,24H,8-9,12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480527 (3-cyclopropyl-1-(3-(difluoromethyl)-2-(4-methyl-1H...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(c(cc12)C(F)F)-n1cnc(C)c1 Show InChI InChI=1S/C25H24F2N6O/c1-13-10-32(12-28-13)24-18(22(26)27)9-17-16(5-4-6-19(17)29-24)21-20-11-31(3)25(34)14(2)33(20)23(30-21)15-7-8-15/h4-6,9-10,12,14-15,22H,7-8,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480592 (3-cyclopropyl-1-(3- (difluoromethyl)-2-(oxazol- 2-...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3ncco3)c(cc12)C(F)F Show InChI InChI=1S/C24H21F2N5O2/c1-12-24(32)30(2)11-18-19(29-22(31(12)18)13-6-7-13)14-4-3-5-17-15(14)10-16(21(25)26)20(28-17)23-27-8-9-33-23/h3-5,8-10,12-13,21H,6-7,11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480609 (1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquino...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1 |(1.37,5.11,;.9,3.65,;-.61,3.33,;-1.64,4.47,;-1.09,1.86,;-2.57,1.46,;-.05,.72,;1.45,1.04,;2.7,.13,;3.94,1.04,;3.47,2.5,;4.24,3.84,;5.78,3.84,;6.55,5.17,;5.78,6.5,;4.24,6.5,;3.47,5.17,;1.93,2.5,;2.7,-1.41,;4.03,-2.18,;5.36,-1.41,;4.03,-3.72,;2.7,-4.49,;1.36,-3.72,;.03,-4.49,;-1.3,-3.72,;-1.3,-2.18,;.03,-1.41,;1.36,-2.18,;-2.64,-4.49,;-2.64,-6.03,;-4.1,-6.5,;-5.01,-5.26,;-6.55,-5.26,;-4.1,-4.01,)| Show InChI InChI=1S/C26H27FN6O2/c1-15-26(34)31(2)14-22-24(29-25(33(15)22)16-7-10-35-11-8-16)23-18-13-28-21(20-6-9-32(3)30-20)12-17(18)4-5-19(23)27/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480492 (US10899769, Example 5a) Show SMILES C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)F |r| Show InChI InChI=1S/C27H28F2N6O2/c1-15-27(36)33(2)14-22-24(32-26(35(15)22)16-7-9-37-10-8-16)18-5-4-6-21-19(18)11-20(25(28)29)23(31-21)17-12-30-34(3)13-17/h4-6,11-13,15-16,25H,7-10,14H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM570192 (US11427593, Compound ZB-BD-242) Show SMILES Cc1cc(-c2cc(CS(C)(=O)=O)ccc2Oc2ccc(F)cc2F)n2cn[nH]c(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen kit (Perkin Elmer) was used to detect effect of the compounds on binding of BRD4 bromodomain to acetylated histone H4 polypeptide. The br...				Citation and Details BindingDB Entry DOI: 10.7270/Q2N3016N
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480586 (3-cyclopropyl-1-(3- (difluoromethyl)-2-(2- methylt...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnc(C)s3)c(cc12)C(F)F Show InChI InChI=1S/C25H23F2N5OS/c1-12-25(33)31(3)11-19-21(30-24(32(12)19)14-7-8-14)15-5-4-6-18-16(15)9-17(23(26)27)22(29-18)20-10-28-13(2)34-20/h4-6,9-10,12,14,23H,7-8,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480559 (1-(6-Fluoro-1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cc2c(nn(C)c2cc1F)-c1cnn(C)c1 Show InChI InChI=1S/C25H28FN7O2/c1-14-25(34)30(2)13-21-23(28-24(33(14)21)15-5-7-35-8-6-15)17-9-18-20(10-19(17)26)32(4)29-22(18)16-11-27-31(3)12-16/h9-12,14-15H,5-8,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair

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