Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150812 (US8981106, 2 (SX-576) | USRE47267, Compound 2) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150824 (US8981106, 14 (SX-585) | USRE47267, Compound 14) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150822 (US8981106, 13 (SX-578) | USRE47267, Compound 13) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50255479 (CHEMBL4067429) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Neurosciences Therapeutic Area Unit , GSK Pharmaceuticals R&D , 898 Halei Road, Zhangjiang Hi-Tech Park , Pudong , Shanghai 201203 , P. R. China. Curated by ChEMBL | Assay Description Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as induction of beta-arrest... | J Med Chem 61: 2518-2532 (2018) Article DOI: 10.1021/acs.jmedchem.7b01854 BindingDB Entry DOI: 10.7270/Q2959M1F | |||||||||||
More data for this Ligand-Target Pair |