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Compile Data Set for Download or QSAR

Found 480 hits of ic50 for UniProtKB: O00311   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50237672
PNG
(CHEMBL4089159)
Show SMILES COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
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n/an/a 0.600n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL




Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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n/an/a 0.690n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253706
PNG
(CHEMBL4083927)
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n/an/a 0.700n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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n/an/a 0.850n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50380230
PNG
(CHEMBL2016862)
Show SMILES O=C1NCC2(CCCCC2)c2sc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C15H17N3OS/c19-14-11-6-12(10-7-17-18-8-10)20-13(11)15(9-16-14)4-2-1-3-5-15/h6-8H,1-5,9H2,(H,16,19)(H,17,18)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


ACS Med Chem Lett 2: 720-723 (2011)


Article DOI: 10.1021/ml200029w
BindingDB Entry DOI: 10.7270/Q2SQ91CR
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329436
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CC(C)NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C18H19N5O/c1-11(2)21-17(24)13-10-15(14-8-9-20-18(19)23-14)22-16(13)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H,21,24)(H2,19,20,23)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329435
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCc2ccccc2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O/c23-22-24-12-11-18(27-22)19-13-17(20(26-19)16-9-5-2-6-10-16)21(28)25-14-15-7-3-1-4-8-15/h1-13,26H,14H2,(H,25,28)(H2,23,24,27)
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Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123148
PNG
(US8742113, 242)
Show SMILES Cc1ccsc1CN=C1CC(=O)C(O1)=Cc1c[nH]c2ncccc12 |w:14.16,7.7|
Show InChI InChI=1S/C18H15N3O2S/c1-11-4-6-24-16(11)10-20-17-8-14(22)15(23-17)7-12-9-21-18-13(12)3-2-5-19-18/h2-7,9H,8,10H2,1H3,(H,19,21)/b15-7-,20-17-
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n/an/a 1n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123147
PNG
(US8742113, 239)
Show SMILES O=C1CC(OC1=Cc1c[nH]c2ncccc12)=Nc1ccc2[nH]ncc2c1 |w:6.7,16.19|
Show InChI InChI=1S/C19H13N5O2/c25-16-8-18(23-13-3-4-15-12(6-13)10-22-24-15)26-17(16)7-11-9-21-19-14(11)2-1-5-20-19/h1-7,9-10H,8H2,(H,20,21)(H,22,24)/b17-7-,23-18+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329437
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CNC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-18-15(22)11-9-13(12-7-8-19-16(17)21-12)20-14(11)10-5-3-2-4-6-10/h2-9,20H,1H3,(H,18,22)(H2,17,19,21)
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Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329439
PNG
(4-(3-Carbamoyl-5-pyridin-4-yl-1H-pyrrol-2-yl)-pipe...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C20H26N4O3/c1-20(2,3)27-19(26)24-10-6-14(7-11-24)17-15(18(21)25)12-16(23-17)13-4-8-22-9-5-13/h4-5,8-9,12,14,23H,6-7,10-11H2,1-3H3,(H2,21,25)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50380236
PNG
(CHEMBL2016856)
Show SMILES O=C1CCC2(CCCCC2)c2sc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C16H18N2OS/c19-13-4-7-16(5-2-1-3-6-16)15-12(13)8-14(20-15)11-9-17-18-10-11/h8-10H,1-7H2,(H,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


ACS Med Chem Lett 2: 720-723 (2011)


Article DOI: 10.1021/ml200029w
BindingDB Entry DOI: 10.7270/Q2SQ91CR
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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n/an/a 1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50380229
PNG
(CHEMBL2016996)
Show SMILES O=C1NCC2(CCCCC2)c2sc(cc12)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C17H17N5OS/c23-16-10-6-11(12-13-15(21-8-19-12)22-9-20-13)24-14(10)17(7-18-16)4-2-1-3-5-17/h6,8-9H,1-5,7H2,(H,18,23)(H,19,20,21,22)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


ACS Med Chem Lett 2: 720-723 (2011)


Article DOI: 10.1021/ml200029w
BindingDB Entry DOI: 10.7270/Q2SQ91CR
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443650
PNG
(CHEMBL3093074)
Show SMILES C1CC1[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H17N5O/c1-2-5-12(6-3-1)16(13-8-9-13)22-19-24-23-18(25-19)15-11-21-17-14(15)7-4-10-20-17/h1-7,10-11,13,16H,8-9H2,(H,20,21)(H,22,24)/t16-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253676
PNG
(CHEMBL4087760)
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n/an/a 1.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253759
PNG
(CHEMBL4078941)
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n/an/a 1.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253708
PNG
(CHEMBL4070822)
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n/an/a 1.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50272192
PNG
(4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1...)
Show SMILES Cc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c1-11-9-13(7-8-16(11)20)15-10-14(18-17(21)19-15)12-5-3-2-4-6-12/h2-10,20H,1H3,(H,18,19,21)
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n/an/a 1.40n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Bioorg Med Chem Lett 22: 3727-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.024
BindingDB Entry DOI: 10.7270/Q20C4WS0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253753
PNG
(CHEMBL4062209)
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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253702
PNG
(CHEMBL4080673)
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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253677
PNG
(CHEMBL4095460)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253706
PNG
(CHEMBL4083927)
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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443651
PNG
(CHEMBL3093073)
Show SMILES CC(C)[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H19N5O/c1-12(2)16(13-7-4-3-5-8-13)22-19-24-23-18(25-19)15-11-21-17-14(15)9-6-10-20-17/h3-12,16H,1-2H3,(H,20,21)(H,22,24)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123131
PNG
(US8742113, 15)
Show SMILES CCOC(=O)C1C(=O)C(OC1=Nc1ccccc1Cl)=Cc1c[nH]c2ncccc12 |w:19.21,11.12|
Show InChI InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,17H,2H2,1H3,(H,23,24)/b16-10-,25-20-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123146
PNG
(US8742113, 233)
Show SMILES Cc1cc(F)ccc1N=C1CC(=O)C(O1)=Cc1c[nH]c2ncccc12 |w:15.17,8.8|
Show InChI InChI=1S/C19H14FN3O2/c1-11-7-13(20)4-5-15(11)23-18-9-16(24)17(25-18)8-12-10-22-19-14(12)3-2-6-21-19/h2-8,10H,9H2,1H3,(H,21,22)/b17-8-,23-18+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329419
PNG
(5-(2-amino-5-bromopyrimidin-4-yl)-2-p-tolyl-1H-pyr...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Br
Show InChI InChI=1S/C15H12BrN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
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Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329434
PNG
(2,5-Dipyridin-4-yl-1H-pyrrole-3-carboxamide | CHEM...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccncc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4O/c16-15(20)12-9-13(10-1-5-17-6-2-10)19-14(12)11-3-7-18-8-4-11/h1-9,19H,(H2,16,20)
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Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253753
PNG
(CHEMBL4062209)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50237689
PNG
(CHEMBL4066943)
Show SMILES COC(=O)C1=C(Nc2ccccc2F)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
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Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor


Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253703
PNG
(CHEMBL4078031)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253674
PNG
(CHEMBL4084945)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50237692
PNG
(CHEMBL4091162)
Show SMILES COC(=O)C1=C(Nc2ccc(F)cc2F)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
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Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor


Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253698
PNG
(CHEMBL4068071)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253668
PNG
(CHEMBL4086790)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50253672
PNG
(CHEMBL4091279)
PDB

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Takeda Pharmaceutical Company, Ltd.

Curated by ChEMBL




Bioorg Med Chem 25: 3658-3670 (2017)


Article DOI: 10.1016/j.bmc.2017.04.044
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123140
PNG
(US8742113, 126)
Show SMILES CCOC(=O)C1C(=O)C(OC1=Nc1ccc(NCCO)cc1C)=Cc1c[nH]c2ncccc12 |w:23.25,11.12|
Show InChI InChI=1S/C24H24N4O5/c1-3-32-24(31)20-21(30)19(12-15-13-27-22-17(15)5-4-8-26-22)33-23(20)28-18-7-6-16(11-14(18)2)25-9-10-29/h4-8,11-13,20,25,29H,3,9-10H2,1-2H3,(H,26,27)/b19-12-,28-23+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50272192
PNG
(4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1...)
Show SMILES Cc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c1-11-9-13(7-8-16(11)20)15-10-14(18-17(21)19-15)12-5-3-2-4-6-12/h2-10,20H,1H3,(H,18,19,21)
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Novartis Institutes of Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of CDC7-DBF4 (unknown origin)


Bioorg Med Chem Lett 18: 4482-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.061
BindingDB Entry DOI: 10.7270/Q2319VPM
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123137
PNG
(US8742113, 89)
Show SMILES OCCCOC(=O)C1C(=O)C(OC1=Nc1ccc(F)cc1)=Cc1c[nH]c2ncccc12 |w:21.23,13.14|
Show InChI InChI=1S/C22H18FN3O5/c23-14-4-6-15(7-5-14)26-21-18(22(29)30-10-2-9-27)19(28)17(31-21)11-13-12-25-20-16(13)3-1-8-24-20/h1,3-8,11-12,18,27H,2,9-10H2,(H,24,25)/b17-11-,26-21-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123144
PNG
(US8742113, 173)
Show SMILES COCCOC(=O)C1C(=O)C(OC1=Nc1ccccc1Cl)=Cc1c[nH]c2ncccc12 |w:21.23,13.14|
Show InChI InChI=1S/C22H18ClN3O5/c1-29-9-10-30-22(28)18-19(27)17(11-13-12-25-20-14(13)5-4-8-24-20)31-21(18)26-16-7-3-2-6-15(16)23/h2-8,11-12,18H,9-10H2,1H3,(H,24,25)/b17-11-,26-21-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123143
PNG
(US8742113, 157)
Show SMILES CC(C)OC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(OCCO)cc1C |w:10.10,22.25|
Show InChI InChI=1S/C25H25N3O6/c1-14(2)33-25(31)21-22(30)20(12-16-13-27-23-18(16)5-4-8-26-23)34-24(21)28-19-7-6-17(11-15(19)3)32-10-9-29/h4-8,11-14,21,29H,9-10H2,1-3H3,(H,26,27)/b20-12-,28-24+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM123142
PNG
(US8742113, 142)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCOCC1 |w:9.9,21.24|
Show InChI InChI=1S/C19H20N4O5/c1-2-27-19(25)15-16(24)14(28-18(15)22-23-6-8-26-9-7-23)10-12-11-21-17-13(12)4-3-5-20-17/h3-5,10-11,15H,2,6-9H2,1H3,(H,20,21)/b14-10-,22-18-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...


US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50237673
PNG
(CHEMBL4098085)
Show SMILES CCOC(=O)C1=C(Nc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:5|
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Carna Biosciences, Inc.

Curated by ChEMBL




Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50237682
PNG
(CHEMBL4083363)
Show SMILES COC(=O)C1=C(Nc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
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Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor


Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383714
PNG
(CHEMBL2030402)
Show SMILES Clc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1 |r|
Show InChI InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Bioorg Med Chem Lett 22: 3727-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.024
BindingDB Entry DOI: 10.7270/Q20C4WS0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50237695
PNG
(CHEMBL4072935)
Show SMILES COC(=O)C1=C(Nc2ccncc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
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n/an/a 3.5n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL




Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50383736
PNG
(CHEMBL2030400)
Show SMILES F[C@H]1CN[C@@H](C1)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1 |r|
Show InChI InChI=1S/C14H11BrFN3O2/c15-6-1-2-10-8(3-6)11-12(21-10)14(20)19-13(18-11)9-4-7(16)5-17-9/h1-3,7,9,17H,4-5H2,(H,18,19,20)/t7-,9+/m1/s1
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n/an/a 3.70n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP


Bioorg Med Chem Lett 22: 3727-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.024
BindingDB Entry DOI: 10.7270/Q20C4WS0
More data for this
Ligand-Target Pair
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