BindingDB PrimarySearch

Found 28 hits of ic50 for UniProtKB: P06612
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259215 (CHEMBL4064887 \| US10266550, Compound 11b) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259244 (CHEMBL4076393 \| US10266550, Compound 16) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259247 (CHEMBL4065223 \| US10266550, Compound 11g) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259214 (CHEMBL4061346 \| US10266550, Compound 11a) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259245 (CHEMBL4064127 \| US10266550, Compound 17a) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	725	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259248 (CHEMBL4104625 \| US10266550, Compound 17bbSelectivi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	725	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259242 (CHEMBL4072011 \| US10266550, Compound 11e) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259221 (CHEMBL4097472 \| US10266550, Compound 11d) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259246 (CHEMBL4066307 \| US10266550, Compound 10a) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259212 (CHEMBL2002459 \| US10266550, Compound 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259246 (CHEMBL4066307 \| US10266550, Compound 10a) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379468 (US10266550, Compound 11c) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379475 (US10266550, Compound 11j) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379478 (US10266550, Compound 15a) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379474 (US10266550, Compound 11i) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379465 (US10266550, Compound 10b) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259242 (CHEMBL4072011 \| US10266550, Compound 11e) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379471 (US10266550, Compound 11f) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379477 (US10266550, Compound 12) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379123 (Ethyl 5,6-difluoro-9-nitro-3-oxo-3H-pyrido[3,2,1-k...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379458 (5, 6-Difluoro-9-nitro-3-oxo-3H-pyrido[3, 2,1-kl]ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379461 (US10266550, Compound 7d) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379476 (US10266550, Compound 11k) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM50259213 (CHEMBL4079855 \| US10266550, Compound 7e) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379459 (9-Cyano-5, 6-d fluoro-3-oxo-3H-pyrido[3, 2, 1-d]ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379133 (Ethyl 9-cyano-5, 6-difluoro-3-oxo-3H-pyrido[3, 2, ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379134 (Ethyl 5, 6-difluoro-3-oxo-9-(trifluoromethyl)-3H-p...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Escherichia coli (strain K12))	BDBM379460 (US10266550, Compound 7c) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
University of Bath					More data for this Ligand-Target Pair