Compile Data Set for Download or QSAR

Found 3 hits of ic50 for UniProtKB: P9WG49   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 1 (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50259247 (CHEMBL4065223 | US10266550, Compound 11g) Show SMILES Nc1ccc2c(c1)oc1c(N3CCC(CC3)N3CCCCC3)c(F)cc3c1n2cc(C(O)=O)c3=O Show InChI InChI=1S/C26H27FN4O4/c27-19-13-17-22-25(23(19)30-10-6-16(7-11-30)29-8-2-1-3-9-29)35-21-12-15(28)4-5-20(21)31(22)14-18(24(17)32)26(33)34/h4-5,12-14,16H,1-3,6-11,28H2,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50259242 (CHEMBL4072011 | US10266550, Compound 11e) Show SMILES Nc1ccc2c(c1)oc1c(NCCN3CCOCC3)c(F)cc3c1n2cc(C(O)=O)c3=O Show InChI InChI=1S/C22H21FN4O5/c23-15-10-13-19-21(18(15)25-3-4-26-5-7-31-8-6-26)32-17-9-12(24)1-2-16(17)27(19)11-14(20(13)28)22(29)30/h1-2,9-11,25H,3-8,24H2,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50259221 (CHEMBL4097472 | US10266550, Compound 11d) Show SMILES Nc1ccc2c(c1)oc1c(N3CCOCC3)c(F)cc3c1n2cc(C(O)=O)c3=O Show InChI InChI=1S/C20H16FN3O5/c21-13-8-11-16-19(17(13)23-3-5-28-6-4-23)29-15-7-10(22)1-2-14(15)24(16)9-12(18(11)25)20(26)27/h1-2,7-9H,3-6,22H2,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath					Assay Description The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...				J Med Chem 51: 4226-38 (2008) BindingDB Entry DOI: 10.7270/Q2H997HD
					More data for this Ligand-Target Pair