Compile Data Set for Download or QSAR

Found 496 hits of ic50 for UniProtKB: Q00960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396904 (US9981950, Example 113B) Show SMILES Nc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C13H11F3N6/c14-11-2-1-9(5-10(11)12(15)16)22-7-8(19-20-22)6-21-4-3-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM398608 (US10323021, Example 114) Show SMILES CC(F)(F)c1cc(ccc1Cl)-n1cc(Cn2ccnc2N)nn1 Show InChI InChI=1S/C14H13ClF2N6/c1-14(16,17)11-6-10(2-3-12(11)15)23-8-9(20-21-23)7-22-5-4-19-13(22)18/h2-6,8H,7H2,1H3,(H2,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396901 (US9981950, Example 110) Show SMILES Nc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1 Show InChI InChI=1S/C13H11ClF2N6O/c14-10-2-1-9(5-11(10)23-12(15)16)22-7-8(19-20-22)6-21-4-3-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396903 (US9981950, Example 113A) Show SMILES Nc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F Show InChI InChI=1S/C13H11ClF2N6/c14-11-2-1-9(5-10(11)12(15)16)22-7-8(19-20-22)6-21-4-3-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204883 ((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...) Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)cc1 Show InChI InChI=1S/C20H21N3O4/c1-12-2-4-13(5-3-12)27-14-6-8-23(9-7-14)20(26)19-21-15-10-17(24)18(25)11-16(15)22-19/h2-5,10-11,14,24-25H,6-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204865 (CHEMBL220611 | [4-(4-fluoro-benzyl)-piperidin-1-yl...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C20H20FN3O3/c21-14-3-1-12(2-4-14)9-13-5-7-24(8-6-13)20(27)19-22-15-10-17(25)18(26)11-16(15)23-19/h1-4,10-11,13,25-26H,5-9H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204868 (CHEMBL424752 | N-[2-(4-benzyl-piperidin-1-carbonyl...) Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1NS(C)(=O)=O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H27N5O5S2/c1-33(29,30)25-19-13-17-18(14-20(19)26-34(2,31)32)24-21(23-17)22(28)27-10-8-16(9-11-27)12-15-6-4-3-5-7-15/h3-7,13-14,16,25-26H,8-12H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396889 (US9981950, Example 96) Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1 Show InChI InChI=1S/C15H14ClF2N5O/c1-2-14-19-5-6-22(14)8-10-9-23(21-20-10)11-3-4-12(16)13(7-11)24-15(17)18/h3-7,9,15H,2,8H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396848 (US9981950, Example 55) Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(C)c1 Show InChI InChI=1S/C14H14ClN5/c1-10-7-13(3-4-14(10)15)20-9-12(17-18-20)8-19-6-5-16-11(19)2/h3-7,9H,8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.64	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204882 (CHEMBL375615 | [4-(4-chloro-phenoxy)-piperidin-1-y...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(Cl)cc1 Show InChI InChI=1S/C19H18ClN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396863 (US9981950, Example 70) Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(C)c1 Show InChI InChI=1S/C15H16ClN5/c1-3-15-17-6-7-20(15)9-12-10-21(19-18-12)13-4-5-14(16)11(2)8-13/h4-8,10H,3,9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.84	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396893 (US9981950, Example 100) Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(OC(F)F)c1 Show InChI InChI=1S/C14H12F3N5O/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-12(15)13(6-11)23-14(16)17/h2-6,8,14H,7H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396902 (US9981950, Example 111) Show SMILES Nc1nccn1Cc1cn(nn1)-c1cc(F)cc(c1)C(F)F Show InChI InChI=1S/C13H11F3N6/c14-9-3-8(12(15)16)4-11(5-9)22-7-10(19-20-22)6-21-2-1-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.13	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204899 ((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396891 (US9981950, Example 98) Show SMILES OCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1 Show InChI InChI=1S/C15H14ClF2N5O2/c16-12-2-1-11(7-13(12)25-15(17)18)23-9-10(20-21-23)8-22-5-4-19-14(22)3-6-24/h1-2,4-5,7,9,15,24H,3,6,8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.26	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204887 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methyl-benz...) Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O3/c1-13-3-2-4-15(9-13)10-14-5-7-24(8-6-14)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,9,11-12,14,25-26H,5-8,10H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396884 (US9981950, Example 91) Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F Show InChI InChI=1S/C15H14ClF2N5/c1-2-14-19-5-6-22(14)8-10-9-23(21-20-10)11-3-4-13(16)12(7-11)15(17)18/h3-7,9,15H,2,8H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.43	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204861 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methoxy-ben...) Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O4/c1-28-15-4-2-3-14(10-15)9-13-5-7-24(8-6-13)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,10-13,25-26H,5-9H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204864 (CHEMBL220474 | [4-(4-fluoro-phenoxy)-piperidin-1-y...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204868 (CHEMBL424752 | N-[2-(4-benzyl-piperidin-1-carbonyl...) Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1NS(C)(=O)=O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H27N5O5S2/c1-33(29,30)25-19-13-17-18(14-20(19)26-34(2,31)32)24-21(23-17)22(28)27-10-8-16(9-11-27)12-15-6-4-3-5-7-15/h3-7,13-14,16,25-26H,8-12H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189391 ((5-hydroxy-1H-benzo[d]imidazol-2-yl)(4-(p-tolyloxy...) Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)cc1 Show InChI InChI=1S/C20H21N3O3/c1-13-2-5-15(6-3-13)26-16-8-10-23(11-9-16)20(25)19-21-17-7-4-14(24)12-18(17)22-19/h2-7,12,16,24H,8-11H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204883 ((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...) Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)cc1 Show InChI InChI=1S/C20H21N3O4/c1-12-2-4-13(5-3-12)27-14-6-8-23(9-7-14)20(26)19-21-15-10-17(24)18(25)11-16(15)22-19/h2-5,10-11,14,24-25H,6-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204863 ((4-benzyl-piperidin-1-yl)-[4(7)-hydroxy-1H-benzimi...) Show SMILES Oc1ccc(O)c2[nH]c(nc12)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O3/c24-15-6-7-16(25)18-17(15)21-19(22-18)20(26)23-10-8-14(9-11-23)12-13-4-2-1-3-5-13/h1-7,14,24-25H,8-12H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204861 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methoxy-ben...) Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O4/c1-28-15-4-2-3-14(10-15)9-13-5-7-24(8-6-13)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,10-13,25-26H,5-9H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189380 (CHEMBL215372 | N-(2-(4-benzylpiperidine-1-carbonyl...) Show SMILES CS(=O)(=O)Nc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H24N4O3S/c1-29(27,28)24-17-7-8-18-19(14-17)23-20(22-18)21(26)25-11-9-16(10-12-25)13-15-5-3-2-4-6-15/h2-8,14,16,24H,9-13H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396890 (US9981950, Example 97) Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1 Show InChI InChI=1S/C16H16ClF2N5O/c1-10(2)15-20-5-6-23(15)8-11-9-24(22-21-11)12-3-4-13(17)14(7-12)25-16(18)19/h3-7,9-10,16H,8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.12	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189383 ((4-(3-methoxybenzyl)piperidin-1-yl)(5-hydroxy-1H-b...) Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O3/c1-27-17-4-2-3-15(12-17)11-14-7-9-24(10-8-14)21(26)20-22-18-6-5-16(25)13-19(18)23-20/h2-6,12-14,25H,7-11H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396882 (US9981950, Example 89) Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F Show InChI InChI=1S/C14H12ClF2N5/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-13(15)12(6-11)14(16)17/h2-6,8,14H,7H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.37	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396878 (US9981950, Example 85) Show SMILES CCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C16H16F3N5/c1-2-3-15-20-6-7-23(15)9-11-10-24(22-21-11)12-4-5-14(17)13(8-12)16(18)19/h4-8,10,16H,2-3,9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204862 (CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...) Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1 Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204862 (CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...) Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1 Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396874 (US9981950, Example 81) Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C14H12F3N5/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-13(15)12(6-11)14(16)17/h2-6,8,14H,7H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.83	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396887 (US9981950, Example 94) Show SMILES FC(F)Oc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1 Show InChI InChI=1S/C16H14ClF2N5O/c17-13-4-3-12(7-14(13)25-16(18)19)24-9-11(21-22-24)8-23-6-5-20-15(23)10-1-2-10/h3-7,9-10,16H,1-2,8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.91	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204884 (6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...) Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1 Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204884 (6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...) Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1 Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204865 (CHEMBL220611 | [4-(4-fluoro-benzyl)-piperidin-1-yl...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C20H20FN3O3/c21-14-3-1-12(2-4-14)9-13-5-7-24(8-6-13)20(27)19-22-15-10-17(25)18(26)11-16(15)23-19/h1-4,10-11,13,25-26H,5-9H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241126 ((4-benzylpiperidin-1-yl)(5-hydroxy-1H-benzo[d]imid...) Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O2/c24-16-6-7-17-18(13-16)22-19(21-17)20(25)23-10-8-15(9-11-23)12-14-4-2-1-3-5-14/h1-7,13,15,24H,8-12H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189385 ((4-(4-fluorobenzyl)piperidin-1-yl)(5-hydroxy-1H-be...) Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C20H20FN3O2/c21-15-3-1-13(2-4-15)11-14-7-9-24(10-8-14)20(26)19-22-17-6-5-16(25)12-18(17)23-19/h1-6,12,14,25H,7-11H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204899 ((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396898 (US9981950, Example 105) Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(C)(F)F Show InChI InChI=1S/C15H14F3N5/c1-10-19-5-6-22(10)8-11-9-23(21-20-11)12-3-4-14(16)13(7-12)15(2,17)18/h3-7,9H,8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.05	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396876 (US9981950, Example 83) Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C15H14F3N5/c1-2-14-19-5-6-22(14)8-10-9-23(21-20-10)11-3-4-13(16)12(7-11)15(17)18/h3-7,9,15H,2,8H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.11	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396894 (US9981950, Example 101) Show SMILES OCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(OC(F)F)c1 Show InChI InChI=1S/C15H14F3N5O2/c16-12-2-1-11(7-13(12)25-15(17)18)23-9-10(20-21-23)8-22-5-4-19-14(22)3-6-24/h1-2,4-5,7,9,15,24H,3,6,8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.26	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396879 (US9981950, Example 86) Show SMILES CCCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C17H18F3N5/c1-2-3-4-16-21-7-8-24(16)10-12-11-25(23-22-12)13-5-6-15(18)14(9-13)17(19)20/h5-9,11,17H,2-4,10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.29	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204895 ((4-amino-1H-indol-2-yl)-(4-benzyl-piperidin-1-yl)-...) Show SMILES Nc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H23N3O/c22-18-7-4-8-19-17(18)14-20(23-19)21(25)24-11-9-16(10-12-24)13-15-5-2-1-3-6-15/h1-8,14,16,23H,9-13,22H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241129 ((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(4-methyl-ben...) Show SMILES Cc1ccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)cc1 Show InChI InChI=1S/C21H23N3O2/c1-14-2-4-15(5-3-14)12-16-8-10-24(11-9-16)21(26)20-22-18-7-6-17(25)13-19(18)23-20/h2-7,13,16,25H,8-12H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396864 (US9981950, Example 71) Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(C)c1 Show InChI InChI=1S/C16H18ClN5/c1-11(2)16-18-6-7-21(16)9-13-10-22(20-19-13)14-4-5-15(17)12(3)8-14/h4-8,10-11H,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.47	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM396826 (US9981950, Example 33) Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H13Cl2N5/c1-2-14-17-5-6-20(14)8-10-9-21(19-18-10)11-3-4-12(15)13(16)7-11/h3-7,9H,2,8H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...				Bioorg Med Chem Lett 18: 3168-72 (2008) BindingDB Entry DOI: 10.7270/Q2JW8H7X
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204887 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methyl-benz...) Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O3/c1-13-3-2-4-15(9-13)10-14-5-7-24(8-6-14)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,9,11-12,14,25-26H,5-8,10H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204873 ((4-benzylpiperidin-1-yl)-(3,6-dihydro-pirrolo[3,2-...) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]ncc23)[nH]1 Show InChI InChI=1S/C22H22N4O/c27-22(21-13-17-18-14-23-25-20(18)7-6-19(17)24-21)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,24H,8-12H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241127 ((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(3-methyl-ben...) Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O2/c1-14-3-2-4-16(11-14)12-15-7-9-24(10-8-15)21(26)20-22-18-6-5-17(25)13-19(18)23-20/h2-6,11,13,15,25H,7-10,12H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair

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