Compile Data Set for Download or QSAR

Found 26 hits of ic50 for UniProtKB: P08922   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267453 (US10688100, Compound 36 | US10966985, Compound 36 ...) Show SMILES CC1(C)CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C21H23FN6O2/c1-21(2)11-24-19(29)15-10-25-28-7-5-17(26-18(15)28)27-6-3-4-16(27)14-8-13(22)9-23-20(14)30-12-21/h5,7-10,16H,3-4,6,11-12H2,1-2H3,(H,24,29)/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267407 (US10966985, Compound 3 | US9718822, 3 | US9750744,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H19FN6O2/c20-12-9-13-15-3-1-6-25(15)16-4-7-26-17(24-16)14(11-23-26)18(27)21-5-2-8-28-19(13)22-10-12/h4,7,9-11,15H,1-3,5-6,8H2,(H,21,27)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM50507492 (Loxo-195 | Selitrectinib | US10966985, Compound 33...) Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2 Show InChI InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267453 (US10688100, Compound 36 | US10966985, Compound 36 ...) Show SMILES CC1(C)CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C21H23FN6O2/c1-21(2)11-24-19(29)15-10-25-28-7-5-17(26-18(15)28)27-6-3-4-16(27)14-8-13(22)9-23-20(14)30-12-21/h5,7-10,16H,3-4,6,11-12H2,1-2H3,(H,24,29)/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267414 (US10688100, Compound 7 | US10966985, Compound 7 | ...) Show SMILES O[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM446700 ((6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapent...) Show SMILES Fc1cnc2CCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C20H21FN6O/c21-13-10-14-16(23-11-13)4-1-2-7-22-20(28)15-12-24-27-9-6-18(25-19(15)27)26-8-3-5-17(14)26/h6,9-12,17H,1-5,7-8H2,(H,22,28)/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267434 (US10688100, Compound 19 | US10966985, Compound 19 ...) Show SMILES Fc1cnc2OCC(F)(F)CNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H17F3N6O2/c20-11-6-12-14-2-1-4-27(14)15-3-5-28-16(26-15)13(8-25-28)17(29)24-9-19(21,22)10-30-18(12)23-7-11/h3,5-8,14H,1-2,4,9-10H2,(H,24,29)/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267416 (US10688100, Compound 9 | US10966985, Compound 9 | ...) Show SMILES Fc1cnc2OCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O2/c19-11-8-12-14-2-1-5-24(14)15-3-6-25-16(23-15)13(10-22-25)17(26)20-4-7-27-18(12)21-9-11/h3,6,8-10,14H,1-2,4-5,7H2,(H,20,26)/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267436 (US10688100, Compound 20 | US10966985, Compound 20 ...) Show SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C20H20FN5O2/c21-13-4-5-17-14(11-13)16-3-1-8-25(16)18-6-9-26-19(24-18)15(12-23-26)20(27)22-7-2-10-28-17/h4-6,9,11-12,16H,1-3,7-8,10H2,(H,22,27)/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267434 (US10688100, Compound 19 | US10966985, Compound 19 ...) Show SMILES Fc1cnc2OCC(F)(F)CNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H17F3N6O2/c20-11-6-12-14-2-1-4-27(14)15-3-5-28-16(26-15)13(8-25-28)17(29)24-9-19(21,22)10-30-18(12)23-7-11/h3,5-8,14H,1-2,4,9-10H2,(H,24,29)/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267436 (US10688100, Compound 20 | US10966985, Compound 20 ...) Show SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C20H20FN5O2/c21-13-4-5-17-14(11-13)16-3-1-8-25(16)18-6-9-26-19(24-18)15(12-23-26)20(27)22-7-2-10-28-17/h4-6,9,11-12,16H,1-3,7-8,10H2,(H,22,27)/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267414 (US10688100, Compound 7 | US10966985, Compound 7 | ...) Show SMILES O[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM50507492 (Loxo-195 | Selitrectinib | US10966985, Compound 33...) Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2 Show InChI InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267469 (US10688100, Compound 45 | US10966985, Compound 45 ...) Show SMILES O[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CC(F)(F)CC2c2cc(F)ccc2OC1 |r| Show InChI InChI=1S/C20H18F3N5O3/c21-11-1-2-16-13(5-11)15-6-20(22,23)10-27(15)17-3-4-28-18(26-17)14(8-25-28)19(30)24-7-12(29)9-31-16/h1-5,8,12,15,29H,6-7,9-10H2,(H,24,30)/t12-,15?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267424 (US10688100, Compound 14 | US10966985, Compound 14 ...) Show SMILES Fc1cnc2OCCOC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H16FN5O3/c19-11-8-12-14-2-1-4-23(14)15-3-5-24-16(22-15)13(10-21-24)18(25)27-7-6-26-17(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267416 (US10688100, Compound 9 | US10966985, Compound 9 | ...) Show SMILES Fc1cnc2OCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O2/c19-11-8-12-14-2-1-5-24(14)15-3-6-25-16(23-15)13(10-22-25)17(26)20-4-7-27-18(12)21-9-11/h3,6,8-10,14H,1-2,4-5,7H2,(H,20,26)/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM266501 (US10688100, Compound 2 | US10966985, Compound 2 | ...) Show SMILES O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2 |r| Show InChI InChI=1S/C19H20N6O2/c26-19-13-12-21-25-10-7-16(23-18(13)25)24-9-2-5-15(24)14-4-1-6-17(22-14)27-11-3-8-20-19/h1,4,6-7,10,12,15H,2-3,5,8-9,11H2,(H,20,26)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.9	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM446757 ((6R,15S)-9-fluoro-15-methyl- 2,11,16,20,21,24- hex...) Show SMILES C[C@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2 |r| Show InChI InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267469 (US10688100, Compound 45 | US10966985, Compound 45 ...) Show SMILES O[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CC(F)(F)CC2c2cc(F)ccc2OC1 |r| Show InChI InChI=1S/C20H18F3N5O3/c21-11-1-2-16-13(5-11)15-6-20(22,23)10-27(15)17-3-4-28-18(26-17)14(8-25-28)19(30)24-7-12(29)9-31-16/h1-5,8,12,15,29H,6-7,9-10H2,(H,24,30)/t12-,15?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.8	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM446757 ((6R,15S)-9-fluoro-15-methyl- 2,11,16,20,21,24- hex...) Show SMILES C[C@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2 |r| Show InChI InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	19.6	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267424 (US10688100, Compound 14 | US10966985, Compound 14 ...) Show SMILES Fc1cnc2OCCOC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H16FN5O3/c19-11-8-12-14-2-1-4-23(14)15-3-5-24-16(22-15)13(10-21-24)18(25)27-7-6-26-17(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM266501 (US10688100, Compound 2 | US10966985, Compound 2 | ...) Show SMILES O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2 |r| Show InChI InChI=1S/C19H20N6O2/c26-19-13-12-21-25-10-7-16(23-18(13)25)24-9-2-5-15(24)14-4-1-6-17(22-14)27-11-3-8-20-19/h1,4,6-7,10,12,15H,2-3,5,8-9,11H2,(H,20,26)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267452 (US10688100, Compound 35 | US10966985, Compound 35 ...) Show SMILES C[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C20H21FN6O2/c1-12-8-22-19(28)15-9-23-27-6-4-17(24-18(15)27)26-5-2-3-16(26)14-7-13(21)11-25(10-12)20(14)29/h4,6-7,9,11-12,16H,2-3,5,8,10H2,1H3,(H,22,28)/t12-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267438 (US10688100, Compound 22 | US10966985, Compound 22 ...) Show SMILES CC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O2/c1-14(28)25-9-10-29-19-5-4-16(22)11-17(19)18-3-2-7-26(18)20-6-8-27-21(24-20)15(13-25)12-23-27/h4-6,8,11-12,18H,2-3,7,9-10,13H2,1H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	397	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267452 (US10688100, Compound 35 | US10966985, Compound 35 ...) Show SMILES C[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C20H21FN6O2/c1-12-8-22-19(28)15-9-23-27-6-4-17(24-18(15)27)26-5-2-3-16(26)14-7-13(21)11-25(10-12)20(14)29/h4,6-7,9,11-12,16H,2-3,5,8,10H2,1H3,(H,22,28)/t12-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [D2033N] (Homo sapiens (Human))	BDBM267438 (US10688100, Compound 22 | US10966985, Compound 22 ...) Show SMILES CC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O2/c1-14(28)25-9-10-29-19-5-4-16(22)11-17(19)18-3-2-7-26(18)20-6-8-27-21(24-20)15(13-25)12-23-27/h4-6,8,11-12,18H,2-3,7,9-10,13H2,1H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	713	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair