Compile Data Set for Download or QSAR

Found 665 hits Enz. Inhib. hit(s) with all data for entry = 9733   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340155 ((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H25N7O2/c1-2-21(34)32-15-6-4-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-5-13-28-20/h2-3,5,8-14,16,19H,1,4,6-7,15H2,(H2,27,29)(H,28,30,35)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340156 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C29H29N7O2/c1-3-6-19-13-14-31-23(18-19)33-29(38)21-11-9-20(10-12-21)25-26-27(30)32-15-17-36(26)28(34-25)22-8-5-16-35(22)24(37)7-4-2/h9-15,17-18,22H,3,5-6,8,16H2,1-2H3,(H2,30,32)(H,31,33,38)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340157 ((S,E)-4-(8-amino-3-(1-(4-methoxy- N-methylbut-2- e...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)\C=C\COC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C29H33N7O3/c1-5-7-20-13-14-31-23(18-20)33-29(38)22-11-9-21(10-12-22)25-26-27(30)32-15-16-36(26)28(34-25)19(2)35(3)24(37)8-6-17-39-4/h6,8-16,18-19H,5,7,17H2,1-4H3,(H2,30,32)(H,31,33,38)/b8-6+/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340158 ((S)-4-(8-amino-3-(1- (vinylsulfonyl)piperidin-2- y...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3S(=O)(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H31N7O3S/c1-3-7-19-13-14-30-23(18-19)32-28(36)21-11-9-20(10-12-21)24-25-26(29)31-15-17-34(25)27(33-24)22-8-5-6-16-35(22)39(37,38)4-2/h4,9-15,17-18,22H,2-3,5-8,16H2,1H3,(H2,29,31)(H,30,32,36)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340089 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)c(F)c2)c2c(N)nccn12 |r| Show InChI InChI=1S/C26H22FN7O2/c1-2-6-21(35)33-13-5-7-19(33)25-32-22(23-24(28)30-12-14-34(23)25)16-9-10-17(18(27)15-16)26(36)31-20-8-3-4-11-29-20/h3-4,8-12,14-15,19H,5,7,13H2,1H3,(H2,28,30)(H,29,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340090 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(OC)ccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H29N7O4/c1-38-16-4-6-23(36)34-14-3-5-21(34)27-33-24(25-26(29)31-13-15-35(25)27)18-7-9-19(10-8-18)28(37)32-22-17-20(39-2)11-12-30-22/h4,6-13,15,17,21H,3,5,14,16H2,1-2H3,(H2,29,31)(H,30,32,37)/b6-4+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340064 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)c(F)c2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H26FN7O3/c1-38-15-5-8-22(36)34-13-4-6-20(34)26-33-23(24-25(29)31-12-14-35(24)26)17-9-10-18(19(28)16-17)27(37)32-21-7-2-3-11-30-21/h2-3,5,7-12,14,16,20H,4,6,13,15H2,1H3,(H2,29,31)(H,30,32,37)/b8-5+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340065 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(F)ccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H26FN7O3/c1-38-15-3-5-22(36)34-13-2-4-20(34)26-33-23(24-25(29)31-12-14-35(24)26)17-6-8-18(9-7-17)27(37)32-21-16-19(28)10-11-30-21/h3,5-12,14,16,20H,2,4,13,15H2,1H3,(H2,29,31)(H,30,32,37)/b5-3+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340066 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccon2)c2c(N)nccn12 |r| Show InChI InChI=1S/C26H27N7O4/c1-36-15-4-6-21(34)32-13-3-2-5-19(32)25-30-22(23-24(27)28-12-14-33(23)25)17-7-9-18(10-8-17)26(35)29-20-11-16-37-31-20/h4,6-12,14,16,19H,2-3,5,13,15H2,1H3,(H2,27,28)(H,29,31,35)/b6-4+/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340067 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ncccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H28N8O3/c1-38-17-4-7-21(36)34-15-3-2-6-20(34)25-32-22(23-24(28)29-14-16-35(23)25)18-8-10-19(11-9-18)26(37)33-27-30-12-5-13-31-27/h4-5,7-14,16,20H,2-3,6,15,17H2,1H3,(H2,28,29)(H,30,31,33,37)/b7-4+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340091 (4-(8-amino-3-((S)-1-(2- chloropyrimidine-4- carbon...) Show SMILES Cc1cc(ccc1-c1nc([C@@H]2CCCCN2C(=O)c2ccnc(Cl)n2)n2ccnc(N)c12)C(=O)Nc1ccccn1 |r| Show InChI InChI=1S/C29H26ClN9O2/c1-17-16-18(27(40)36-22-7-2-4-11-32-22)8-9-19(17)23-24-25(31)33-13-15-39(24)26(37-23)21-6-3-5-14-38(21)28(41)20-10-12-34-29(30)35-20/h2,4,7-13,15-16,21H,3,5-6,14H2,1H3,(H2,31,33)(H,32,36,40)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340092 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(C)ccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H29N7O3/c1-18-11-12-30-22(17-18)32-28(37)20-9-7-19(8-10-20)24-25-26(29)31-13-15-35(25)27(33-24)21-5-3-14-34(21)23(36)6-4-16-38-2/h4,6-13,15,17,21H,3,5,14,16H2,1-2H3,(H2,29,31)(H,30,32,37)/b6-4+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340093 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(C)C)c2c(N)nccn12 |r| Show InChI InChI=1S/C30H33N7O3/c1-19(2)22-12-13-32-24(18-22)34-30(39)21-10-8-20(9-11-21)26-27-28(31)33-14-16-37(27)29(35-26)23-6-4-15-36(23)25(38)7-5-17-40-3/h5,7-14,16,18-19,23H,4,6,15,17H2,1-3H3,(H2,31,33)(H,32,34,39)/b7-5+/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340094 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)but-2- en...) Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(C)ccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C29H32N8O2/c1-19-12-13-31-23(18-19)33-29(39)21-10-8-20(9-11-21)25-26-27(30)32-14-17-37(26)28(34-25)22-6-4-16-36(22)24(38)7-5-15-35(2)3/h5,7-14,17-18,22H,4,6,15-16H2,1-3H3,(H2,30,32)(H,31,33,39)/b7-5+/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340159 ((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C29H31N7O2/c1-3-7-19-13-14-31-23(18-19)33-29(38)21-11-9-20(10-12-21)25-26-27(30)32-15-17-36(26)28(34-25)22-8-5-6-16-35(22)24(37)4-2/h4,9-15,17-18,22H,2-3,5-8,16H2,1H3,(H2,30,32)(H,31,33,38)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340161 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CC#CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H24F3N7O2/c1-2-5-22(39)37-14-4-3-6-20(37)26-36-23(24-25(32)34-13-15-38(24)26)17-7-9-18(10-8-17)27(40)35-21-16-19(11-12-33-21)28(29,30)31/h7-13,15-16,20H,3-4,6,14H2,1H3,(H2,32,34)(H,33,35,40)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340163 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)but-2- en...) Show SMILES CC(C)c1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\CN(C)C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C31H36N8O2/c1-20(2)23-13-14-33-25(19-23)35-31(41)22-11-9-21(10-12-22)27-28-29(32)34-15-18-39(28)30(36-27)24-7-5-17-38(24)26(40)8-6-16-37(3)4/h6,8-15,18-20,24H,5,7,16-17H2,1-4H3,(H2,32,34)(H,33,35,41)/b8-6+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340164 (4-(8-amino-3-((S)-1- (vinylsulfonyl)piperidin-2- y...) Show SMILES Cc1cc(ccc1-c1nc([C@@H]2CCCCN2S(=O)(=O)C=C)n2ccnc(N)c12)C(=O)Nc1ccccn1 |r| Show InChI InChI=1S/C26H27N7O3S/c1-3-37(35,36)33-14-7-5-8-20(33)25-31-22(23-24(27)29-13-15-32(23)25)19-11-10-18(16-17(19)2)26(34)30-21-9-4-6-12-28-21/h3-4,6,9-13,15-16,20H,1,5,7-8,14H2,2H3,(H2,27,29)(H,28,30,34)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340165 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2F)-c2nc([C@@H]3CCCCN3C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H30FN7O2/c1-3-7-19-12-13-33-24(17-19)35-30(40)21-11-10-20(18-22(21)31)26-27-28(32)34-14-16-38(27)29(36-26)23-9-5-6-15-37(23)25(39)8-4-2/h10-14,16-18,23H,3,5-7,9,15H2,1-2H3,(H2,32,34)(H,33,35,40)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340068 (4-(3-((S)-1-acryloylpiperidin-2-yl)-8- aminoimidaz...) Show SMILES Cc1cc(ccc1-c1nc([C@@H]2CCCCN2C(=O)C=C)n2ccnc(N)c12)C(=O)Nc1ccccn1 |r| Show InChI InChI=1S/C27H27N7O2/c1-3-22(35)33-14-7-5-8-20(33)26-32-23(24-25(28)30-13-15-34(24)26)19-11-10-18(16-17(19)2)27(36)31-21-9-4-6-12-29-21/h3-4,6,9-13,15-16,20H,1,5,7-8,14H2,2H3,(H2,28,30)(H,29,31,36)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340096 ((E)-4-(8-amino-3-((4-(dimethyl amino)but-2-enamido...) Show SMILES CN(C)C\C=C\C(=O)NCc1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 Show InChI InChI=1S/C25H26N8O2/c1-32(2)14-5-7-21(34)29-16-20-31-22(23-24(26)28-13-15-33(20)23)17-8-10-18(11-9-17)25(35)30-19-6-3-4-12-27-19/h3-13,15H,14,16H2,1-2H3,(H2,26,28)(H,29,34)(H,27,30,35)/b7-5+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340097 ((S)-4-(8-amino-3-(1-(2-chloro pyrimidine-4-carbony...) Show SMILES CC(C)c1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)c3ccnc(Cl)n3)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H28ClN9O2/c1-17(2)20-9-11-33-23(16-20)37-28(41)19-7-5-18(6-8-19)24-25-26(32)34-13-15-40(25)27(38-24)22-4-3-14-39(22)29(42)21-10-12-35-30(31)36-21/h5-13,15-17,22H,3-4,14H2,1-2H3,(H2,32,34)(H,33,37,41)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340098 ((S)-4-(8-amino-3-(1-(2-chloro pyrimidine-4-carbony...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nc4CCCCc4s3)c12)[C@@H]1CCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C29H26ClN9O2S/c30-28-33-12-11-19(34-28)27(41)38-14-3-5-20(38)25-36-22(23-24(31)32-13-15-39(23)25)16-7-9-17(10-8-16)26(40)37-29-35-18-4-1-2-6-21(18)42-29/h7-13,15,20H,1-6,14H2,(H2,31,32)(H,35,37,40)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340069 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cccnn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H28N8O3/c1-38-17-5-8-22(36)34-15-3-2-6-20(34)26-32-23(24-25(28)29-14-16-35(24)26)18-9-11-19(12-10-18)27(37)31-21-7-4-13-30-33-21/h4-5,7-14,16,20H,2-3,6,15,17H2,1H3,(H2,28,29)(H,31,33,37)/b8-5+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340099 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)but-2- en...) Show SMILES CN(C)C\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cccnn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H31N9O2/c1-35(2)16-6-9-23(38)36-17-4-3-7-21(36)27-33-24(25-26(29)30-15-18-37(25)27)19-10-12-20(13-11-19)28(39)32-22-8-5-14-31-34-22/h5-6,8-15,18,21H,3-4,7,16-17H2,1-2H3,(H2,29,30)(H,32,34,39)/b9-6+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340070 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cccnn3)c12)[C@@H]1CCCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C27H23ClN10O2/c28-27-31-12-10-18(33-27)26(40)37-14-2-1-4-19(37)24-35-21(22-23(29)30-13-15-38(22)24)16-6-8-17(9-7-16)25(39)34-20-5-3-11-32-36-20/h3,5-13,15,19H,1-2,4,14H2,(H2,29,30)(H,34,36,39)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340166 ((S,E)-4-(8-amino-3-(1-(4-methoxy- N-methylbut-2- e...) Show SMILES COC\C=C\C(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H26F3N7O3/c1-16(36(2)21(38)5-4-14-40-3)25-35-22(23-24(31)33-12-13-37(23)25)17-6-8-18(9-7-17)26(39)34-20-15-19(10-11-32-20)27(28,29)30/h4-13,15-16H,14H2,1-3H3,(H2,31,33)(H,32,34,39)/b5-4+/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340168 ((S,E)-4-(8-amino-3-(1-(4- (pyrrolidin-1-yl)but-2- ...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\CN3CCCC3)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C33H38N8O2/c1-2-7-23-14-15-35-27(22-23)37-33(43)25-12-10-24(11-13-25)29-30-31(34)36-16-21-41(30)32(38-29)26-8-5-20-40(26)28(42)9-6-19-39-17-3-4-18-39/h6,9-16,21-22,26H,2-5,7-8,17-20H2,1H3,(H2,34,36)(H,35,37,43)/b9-6+/t26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340169 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)but-2- en...) Show SMILES CN(C)C\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C29H32N8O2/c1-35(2)17-7-10-24(38)36-18-6-4-8-22(36)28-34-25(26-27(30)32-16-19-37(26)28)20-11-13-21(14-12-20)29(39)33-23-9-3-5-15-31-23/h3,5,7,9-16,19,22H,4,6,8,17-18H2,1-2H3,(H2,30,32)(H,31,33,39)/b10-7+/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340170 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)c3ccnc(Cl)n3)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H28ClN9O2/c1-2-4-18-10-12-33-23(17-18)37-28(41)20-8-6-19(7-9-20)24-25-26(32)34-14-16-40(25)27(38-24)22-5-3-15-39(22)29(42)21-11-13-35-30(31)36-21/h6-14,16-17,22H,2-5,15H2,1H3,(H2,32,34)(H,33,37,41)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340100 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(F)ccn3)c12)[C@@H]1CCCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C28H23ClFN9O2/c29-28-34-11-9-19(35-28)27(41)38-13-2-1-3-20(38)25-37-22(23-24(31)33-12-14-39(23)25)16-4-6-17(7-5-16)26(40)36-21-15-18(30)8-10-32-21/h4-12,14-15,20H,1-3,13H2,(H2,31,33)(H,32,36,40)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340101 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(F)ccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H28FN7O3/c1-39-16-4-6-23(37)35-14-3-2-5-21(35)27-34-24(25-26(30)32-13-15-36(25)27)18-7-9-19(10-8-18)28(38)33-22-17-20(29)11-12-31-22/h4,6-13,15,17,21H,2-3,5,14,16H2,1H3,(H2,30,32)(H,31,33,38)/b6-4+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340102 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nc3CCCCc3s2)c2c(N)nccn12 |r| Show InChI InChI=1S/C29H31N7O3S/c1-39-17-5-9-23(37)35-15-4-7-21(35)27-33-24(25-26(30)31-14-16-36(25)27)18-10-12-19(13-11-18)28(38)34-29-32-20-6-2-3-8-22(20)40-29/h5,9-14,16,21H,2-4,6-8,15,17H2,1H3,(H2,30,31)(H,32,34,38)/b9-5+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340103 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES COc1cc(ccc1C(=O)Nc1ccccn1)-c1nc([C@@H]2CCCN2C(=O)c2ccnc(Cl)n2)n2ccnc(N)c12 |r| Show InChI InChI=1S/C28H24ClN9O3/c1-41-20-15-16(7-8-17(20)26(39)35-21-6-2-3-10-31-21)22-23-24(30)32-12-14-38(23)25(36-22)19-5-4-13-37(19)27(40)18-9-11-33-28(29)34-18/h2-3,6-12,14-15,19H,4-5,13H2,1H3,(H2,30,32)(H,31,35,39)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340104 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES Nc1nccn2c(nc(-c3ccc(C(=O)Nc4ccccn4)c(F)c3)c12)[C@@H]1CCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C27H21ClFN9O2/c28-27-33-10-8-18(34-27)26(40)37-12-3-4-19(37)24-36-21(22-23(30)32-11-13-38(22)24)15-6-7-16(17(29)14-15)25(39)35-20-5-1-2-9-31-20/h1-2,5-11,13-14,19H,3-4,12H2,(H2,30,32)(H,31,35,39)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340071 (4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pip...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2C)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C29H31N7O3/c1-19-18-20(29(38)33-23-9-3-5-13-31-23)11-12-21(19)25-26-27(30)32-14-16-36(26)28(34-25)22-8-4-6-15-35(22)24(37)10-7-17-39-2/h3,5,7,9-14,16,18,22H,4,6,8,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b10-7+/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340072 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccncn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H28N8O3/c1-38-16-4-6-22(36)34-14-3-2-5-20(34)26-33-23(24-25(28)30-13-15-35(24)26)18-7-9-19(10-8-18)27(37)32-21-11-12-29-17-31-21/h4,6-13,15,17,20H,2-3,5,14,16H2,1H3,(H2,28,30)(H,29,31,32,37)/b6-4+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340073 (4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pyr...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN4C(=O)\C=C\COC)n4ccnc(N)c34)c(C)c2)c1 |r| Show InChI InChI=1S/C31H35N7O3/c1-4-7-21-12-13-33-25(19-21)35-31(40)22-10-11-23(20(2)18-22)27-28-29(32)34-14-16-38(28)30(36-27)24-8-5-15-37(24)26(39)9-6-17-41-3/h6,9-14,16,18-19,24H,4-5,7-8,15,17H2,1-3H3,(H2,32,34)(H,33,35,40)/b9-6+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340074 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccc(C)n2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H30N8O3/c1-18-12-13-31-28(32-18)34-27(38)20-10-8-19(9-11-20)23-24-25(29)30-14-16-36(24)26(33-23)21-6-3-4-15-35(21)22(37)7-5-17-39-2/h5,7-14,16,21H,3-4,6,15,17H2,1-2H3,(H2,29,30)(H,31,32,34,38)/b7-5+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340105 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CC#CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccc(C)n2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H26N8O2/c1-3-6-21(36)34-15-5-4-7-20(34)25-32-22(23-24(28)29-14-16-35(23)25)18-8-10-19(11-9-18)26(37)33-27-30-13-12-17(2)31-27/h8-14,16,20H,4-5,7,15H2,1-2H3,(H2,28,29)(H,30,31,33,37)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340075 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ncccn3)c12)[C@@H]1CCCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C27H23ClN10O2/c28-26-31-12-9-18(34-26)25(40)37-14-2-1-4-19(37)23-35-20(21-22(29)30-13-15-38(21)23)16-5-7-17(8-6-16)24(39)36-27-32-10-3-11-33-27/h3,5-13,15,19H,1-2,4,14H2,(H2,29,30)(H,32,33,36,39)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340062 ((S)-4-(8-amino-3-(1- methacryloylpyrrolidin-2- yl)...) Show SMILES CC(=C)C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C26H25N7O2/c1-16(2)26(35)32-14-5-6-19(32)24-31-21(22-23(27)29-13-15-33(22)24)17-8-10-18(11-9-17)25(34)30-20-7-3-4-12-28-20/h3-4,7-13,15,19H,1,5-6,14H2,2H3,(H2,27,29)(H,28,30,34)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340076 ((S)-4-(8-amino-3-(1-(2- (trifluoromethyl)acryloyl)...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1C(=O)C(=C)C(F)(F)F |r| Show InChI InChI=1S/C26H22F3N7O2/c1-15(26(27,28)29)25(38)35-13-4-5-18(35)23-34-20(21-22(30)32-12-14-36(21)23)16-7-9-17(10-8-16)24(37)33-19-6-2-3-11-31-19/h2-3,6-12,14,18H,1,4-5,13H2,(H2,30,32)(H,31,33,37)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340077 ((S,E)-4-(8-amino-3-(1-but-2- enoylpyrrolidin-2-yl)...) Show SMILES C\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C26H25N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h2-4,6,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/b6-2+/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340078 ((S)-4-(8-amino-3-(1- (cyanomethyl)pyrrolidin-2- yl...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1CC#N |r| Show InChI InChI=1S/C24H22N8O/c25-10-14-31-13-3-4-18(31)23-30-20(21-22(26)28-12-15-32(21)23)16-6-8-17(9-7-16)24(33)29-19-5-1-2-11-27-19/h1-2,5-9,11-12,15,18H,3-4,13-14H2,(H2,26,28)(H,27,29,33)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340106 ((E)-4-(8-amino-3-((4-methoxybut-2- enamido)methyl)...) Show SMILES COC\C=C\C(=O)NCc1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 Show InChI InChI=1S/C24H23N7O3/c1-34-14-4-6-20(32)28-15-19-30-21(22-23(25)27-12-13-31(19)22)16-7-9-17(10-8-16)24(33)29-18-5-2-3-11-26-18/h2-13H,14-15H2,1H3,(H2,25,27)(H,28,32)(H,26,29,33)/b6-4+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340107 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)N2CCCC2)c2c(N)nccn12 |r| Show InChI InChI=1S/C30H30N8O2/c1-2-6-25(39)37-17-5-7-23(37)29-35-26(27-28(31)33-14-18-38(27)29)20-8-10-21(11-9-20)30(40)34-24-19-22(12-13-32-24)36-15-3-4-16-36/h8-14,18-19,23H,3-5,7,15-17H2,1H3,(H2,31,33)(H,32,34,40)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM484651 ((E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan...) Show SMILES COC\C=C\C(=O)N1CCCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C29H31N7O3/c1-39-19-7-10-24(37)35-17-6-2-3-8-22(35)28-34-25(26-27(30)32-16-18-36(26)28)20-11-13-21(14-12-20)29(38)33-23-9-4-5-15-31-23/h4-5,7,9-16,18,22H,2-3,6,8,17,19H2,1H3,(H2,30,32)(H,31,33,38)/b10-7+/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340109 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C#N)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H26N8O3/c1-39-15-3-5-23(37)35-13-2-4-21(35)27-34-24(25-26(30)32-12-14-36(25)27)19-6-8-20(9-7-19)28(38)33-22-16-18(17-29)10-11-31-22/h3,5-12,14,16,21H,2,4,13,15H2,1H3,(H2,30,32)(H,31,33,38)/b5-3+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340110 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES COc1cc(ccc1C(=O)Nc1ccccn1)-c1nc([C@@H]2CCCN2C(=O)C#CC)n2ccnc(N)c12 |r| Show InChI InChI=1S/C27H25N7O3/c1-3-7-22(35)33-14-6-8-19(33)26-32-23(24-25(28)30-13-15-34(24)26)17-10-11-18(20(16-17)37-2)27(36)31-21-9-4-5-12-29-21/h4-5,9-13,15-16,19H,6,8,14H2,1-2H3,(H2,28,30)(H,29,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 665 total )  |  Next  |  Last  >>

Jump to: