Compile Data Set for Download or QSAR

Found 420 hits Enz. Inhib. hit(s) with all data for entry = 9964   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503988 (2-[[8-amino-6-(4-methylpyridin-3-yl)-2,7- naphthyr...) Show SMILES CN1CCc2cc(Nc3cc4cc(nc(N)c4cn3)-c3cnccc3C)nn2CC1=O Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503940 (1-(3-(4-(8-amino-6-(4-methylpyridin-3- yl)-2,7-nap...) Show SMILES CC(=O)N1CC[C@@H](C1)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503914 ((1S,2S)-N-(8-amino-5-fluoro-6-(4- methylpyridin-3-...) Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3c3cn[nH]c3)cc2c1F |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503879 (1-[3-[4-[[8-amino-6-(4-methyl-3-pyridyl)- 2,7-naph...) Show SMILES CC(=O)N1CC(C1)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503863 (US11034692, Compound 146 | trans-N-[8-amino-6-(4-m...) Show SMILES CCS(=O)(=O)n1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504062 ((1R,2R)-N-(8-amino-6-(4-methylpyridin- 3-yl)-2,7-n...) Show SMILES COCCn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504051 ((1S,2S)—N-(8-amino-6-(4-methyl-2-phenylpyridi...) Show SMILES Cc1ccnc(-c2ccccc2)c1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504049 ((1R,2S)—N-(8-amino-5-cyclopropyl-6-(4-methylp...) Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1C1CC1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504044 (US11034692, Compound 313) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@]33CCNC(=O)C3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503999 (3-[[8-Amino-6-(4-methylpyridin-3-yl)-2,7- naphthyr...) Show SMILES CNC(=O)c1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)nn1C Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503978 (US11034692, Compound 247) Show SMILES Cc1c(N)cncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503943 (1-(3-(8-amino-6-(4-methylpyridin-3-yl)- 2,7-naphth...) Show SMILES C[C@@H](O)c1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)nn1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504027 ((1S,2S)—N-[8-amino-6-(2,6-dichlorophenyl)-2,7...) Show SMILES NCCOCCn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(Cl)cccc1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503916 ((1S,2S)-N-(8-amino-6-(4-methylpyridin-3- yl)-2,7-n...) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504034 ((1R,2R)—N-(8-amino-6-(2-chloro-6-fluorophenyl...) Show SMILES Cn1cc(cn1)[C@H]1C[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(F)cccc1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504050 (US11034692, Compound 318) Show SMILES Cc1ccnc(-c2ccccc2)c1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504030 ((1R,2R)—N-[8-amino-6-(2-methylphenyl)-2,7-nap...) Show SMILES Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503936 (US11034692, Compound 214) Show SMILES Cn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1CCO |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504023 (US11034692, Compound 292) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(CCOCCN)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503977 ((1S,2S)—N-(8-amino-6-(4-(2-hydroxyethyl)pyrid...) Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnsc3)ncc12)-c1cnccc1CCO |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503892 (US11034692, Compound 173 | trans-N-(8-amino-5-chlo...) Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3c3cn[nH]c3)cc2c1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503926 (US11034692, Compound 206 | trans-N-(8-amino-6-(4-m...) Show SMILES Cc1ccnc(-c2ccccc2)c1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503939 (2-(4-(8-amino-6-(4-methylpyridin-3-yl)- 2,7-naphth...) Show SMILES CC(C#N)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503839 (US11034692, Compound 122 | trans-N-[8-amino-6-(4-m...) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)C3C[C@@H]3c3cn[nH]c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504009 ((R)-2-(4-(8-amino-6-(4-methylpyridin-3- yl)-2,7-na...) Show SMILES C[C@H](C#N)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504041 (US11034692, Compound 310) Show SMILES Nc1nc(cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc12)-c1c(Cl)cccc1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504032 ((1R,2R)—N-[8-amino-6-(5-cyano-2-methylphenyl)...) Show SMILES Cc1ccc(cc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1)C#N |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504058 (US11034692, Compound 326) Show SMILES C[C@@H]1[C@H]([C@@H]1c1cnn(C)c1)C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0740	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503960 ((1S,2S)—N-(8-amino-5-chloro-6-(4-methylpyridi...) Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)cc2c1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0780	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504017 ((1R,2R)-N-[8-amino-6-(5-hydroxy-2- methylphenyl)-2...) Show SMILES Cc1ccc(O)cc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0780	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503925 (US11034692, Compound 205 | trans-N-(8-amino-5-meth...) Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503985 (US11034692, Compound 253) Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@H]3c3cccnc3)ncc12)-c1cnccc1CCO |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0890	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503795 (3-(4-Ethylpyridin-3-yl)-N6-(1-piperidin-4- yl-1H-p...) Show SMILES CCc1ccncc1-c1cc2cc(Nc3cnn(c3)C3CCNCC3)ncc2c(N)n1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504038 ((1S,2S)—N-[8-amino-6-(2,6-difluorophenyl)-2,7...) Show SMILES Cn1cc(cn1)[C@H]1C[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(F)cccc1F |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504003 (US11034692, Compound 267 | trans-N-(8-amino-6-(5-f...) Show SMILES Cc1ccc(F)cc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.113	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504060 (US11034692, Compound 328) Show SMILES C[C@@H]1[C@@H]([C@H]1c1cnn(C)c1)C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504006 ((1R,2S)—N-[8-amino-5-chloro-6-(4-methylpyridi...) Show SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.116	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504002 (2-(4-[[8-amino-6-(4-methylpyridin-3-yl)- 2,7-napht...) Show SMILES Cc1ccncc1-c1cc2cc(Nc3cnn(c3)C(C)(C)CO)ncc2c(N)n1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.118	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504000 ((4-[[8-Amino-6-(4-methylpyridin-3-yl-2,7- naphthyr...) Show SMILES Cc1ccncc1-c1cc2cc(Nc3ccc(CS(N)(=O)=O)cc3)ncc2c(N)n1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.134	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503945 (US11034692, Compound 223 | cis-N-(8-amino-6-(3,4-d...) Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc12)-c1cncc2NCCOc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.135	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503874 (US11034692, Compound 157 | US11034692, Compound 19...) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3CC#N)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.135	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504008 ((1R,2S)—N-[8-amino-5-ethyl-6-(4-methylpyridin...) Show SMILES CCc1c(nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3CC#N)cc12)-c1cnccc1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.139	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504004 (US11034692, Compound 268 | trans-N-[8-amino-6-(5-h...) Show SMILES Cc1ccc(O)cc1-c1cc2cc(NC(=O)C3CC3c3cnn(C)c3)ncc2c(N)n1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.147	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503869 (US11034692, Compound 152 | trans-N-[8-amino-6-(4-m...) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnsc3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504036 ((1S,2S)—N-[8-amino-6-(2-chlorophenyl)-2,7-nap...) Show SMILES Cn1cc(cn1)[C@H]1C[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1ccccc1Cl |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.152	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503932 (US11034692, Compound 211 | cis-N-(8-amino-6-(2,3-d...) Show SMILES Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc12)-c1cncc2NCCc12 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.154	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503956 (US11034692, Compound 231 | trans-N-(8-amino-6-(4-m...) Show SMILES Cc1ccncc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C3CNC(=O)O3)ncc2c(N)n1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.173	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM503981 ((3R)-3-(4-[[8-amino-6-(4-methylpyridin-3-yl)-2,7-n...) Show SMILES CN1CC[C@@H](C1=O)n1cc(Nc2cc3cc(nc(N)c3cn2)-c2cnccc2C)cn1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.184	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504040 ((1S,2S)—N-[8-amino-6-[4-methyl-6-(1,3-oxazol-...) Show SMILES Cc1cc(ncc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1)-c1ncco1 |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.184	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM504015 ((1S,2S,3R)—N-[8-amino-6-(4-methylpyridin-3-yl...) Show SMILES C[C@@H]1[C@@H](CC#N)[C@@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1cnccc1C |r| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.188	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8
					More data for this Ligand-Target Pair

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