Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10469 (Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10470 (Bis-THA inhibitor 1d | Bis-THA inhibitor 9 | CHEMB...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10469 (Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10475 (N-(8-phenyloctyl)-1,2,3,4-tetrahydroacridin-9-amin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10474 (N-(7-phenylheptyl)-1,2,3,4-tetrahydroacridin-9-ami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 390 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10470 (Bis-THA inhibitor 1d | Bis-THA inhibitor 9 | CHEMB...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10472 (N-(5-phenylpentyl)-1,2,3,4-tetrahydroacridin-9-ami...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 590 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10473 (N-(6-phenylhexyl)-1,2,3,4-tetrahydroacridin-9-amin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 610 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10473 (N-(6-phenylhexyl)-1,2,3,4-tetrahydroacridin-9-amin...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10474 (N-(7-phenylheptyl)-1,2,3,4-tetrahydroacridin-9-ami...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10471 (N-(4-phenylbutyl)-1,2,3,4-tetrahydroacridin-9-amin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10472 (N-(5-phenylpentyl)-1,2,3,4-tetrahydroacridin-9-ami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10475 (N-(8-phenyloctyl)-1,2,3,4-tetrahydroacridin-9-amin...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10476 (N-(9-phenylnonyl)-1,2,3,4-tetrahydroacridin-9-amin...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10477 (N-(10-phenyldecyl)-1,2,3,4-tetrahydroacridin-9-ami...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10476 (N-(9-phenylnonyl)-1,2,3,4-tetrahydroacridin-9-amin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM10477 (N-(10-phenyldecyl)-1,2,3,4-tetrahydroacridin-9-ami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Mayo Foundation for Medical Education and Research | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... | J Biol Chem 271: 23646-9 (1996) Article DOI: 10.1074/jbc.271.39.23646 BindingDB Entry DOI: 10.7270/Q2XW4H0P | |||||||||||
More data for this Ligand-Target Pair |