Found 4 hits Enz. Inhib. hit(s) with all data for entry = 5340 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Promotilin
(Homo sapiens (Human)) | BDBM85389
(CAS_52906-92-0 | Motilin)Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#16]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r| Show InChI InChI=1S/C120H188N34O35S/c1-9-64(6)97(152-114(184)86-31-22-53-154(86)117(187)96(63(4)5)151-99(169)70(123)56-66-23-12-10-13-24-66)115(185)150-84(57-67-25-14-11-15-26-67)113(183)153-98(65(7)155)116(186)149-83(58-68-32-34-69(156)35-33-68)101(171)135-60-91(161)136-75(39-45-93(163)164)105(175)147-82(55-62(2)3)111(181)145-77(37-43-88(125)158)106(176)140-73(29-20-51-132-119(128)129)103(173)146-80(48-54-190-8)110(180)142-76(36-42-87(124)157)107(177)144-79(41-47-95(167)168)108(178)139-72(28-17-19-50-122)102(172)143-78(40-46-94(165)166)109(179)141-74(30-21-52-133-120(130)131)104(174)148-85(59-90(127)160)112(182)138-71(27-16-18-49-121)100(170)134-61-92(162)137-81(118(188)189)38-44-89(126)159/h10-15,23-26,32-35,62-65,70-86,96-98,155-156H,9,16-22,27-31,36-61,121-123H2,1-8H3,(H2,124,157)(H2,125,158)(H2,126,159)(H2,127,160)(H,134,170)(H,135,171)(H,136,161)(H,137,162)(H,138,182)(H,139,178)(H,140,176)(H,141,179)(H,142,180)(H,143,172)(H,144,177)(H,145,181)(H,146,173)(H,147,175)(H,148,174)(H,149,186)(H,150,185)(H,151,169)(H,152,184)(H,153,183)(H,163,164)(H,165,166)(H,167,168)(H,188,189)(H4,128,129,132)(H4,130,131,133)/t64-,65+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,96-,97-,98-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc.
Curated by PDSP Ki Database
| |
Anal Biochem 300: 146-51 (2002)
Article DOI: 10.1006/abio.2001.5466
BindingDB Entry DOI: 10.7270/Q2NK3CM4 |
More data for this
Ligand-Target Pair | |
Promotilin
(Homo sapiens (Human)) | BDBM85846
(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O |r,wU:36.38,25.25,47.52,6.6,43.46,45.48,12.13,30.34,10.9,16.16,27.28,wD:8.8,23.24,47.51,31.33,21.22,12.12,2.1,18.18,c:42,(-6.58,-.4,;-6.58,1.13,;-5.23,1.91,;-3.9,1.13,;-3.9,-.4,;-5.23,-1.2,;-2.57,-1.2,;-2.57,-2.73,;-1.22,-.4,;.11,-1.2,;.11,-2.73,;1.44,-3.5,;1.44,-5.03,;2.99,-5.03,;2.19,-6.39,;3.75,-6.39,;.11,-5.81,;.11,-7.36,;-1.22,-5.03,;-2.57,-5.81,;-1.22,-3.5,;-1.22,1.13,;-2.57,1.91,;.11,1.91,;1.44,1.13,;2.77,1.91,;4.1,1.13,;5.45,1.91,;6.78,1.13,;5.45,3.44,;4.1,4.21,;2.77,3.44,;1.44,4.21,;4.1,5.76,;2.77,6.52,;5.45,6.52,;.11,3.44,;1.64,3.44,;.44,4.9,;-.44,6.16,;.55,7.36,;-2.33,6.72,;-1.88,4.46,;-3.9,5.76,;-5.23,6.52,;-3.9,4.21,;-2.57,3.44,;-5.23,3.44,;-6.78,3.44,;-6.01,4.79,)| Show InChI InChI=1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 19.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc.
Curated by PDSP Ki Database
| |
Anal Biochem 300: 146-51 (2002)
Article DOI: 10.1006/abio.2001.5466
BindingDB Entry DOI: 10.7270/Q2NK3CM4 |
More data for this
Ligand-Target Pair | |
Promotilin
(Homo sapiens (Human)) | BDBM85846
(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O |r,wU:36.38,25.25,47.52,6.6,43.46,45.48,12.13,30.34,10.9,16.16,27.28,wD:8.8,23.24,47.51,31.33,21.22,12.12,2.1,18.18,c:42,(-6.58,-.4,;-6.58,1.13,;-5.23,1.91,;-3.9,1.13,;-3.9,-.4,;-5.23,-1.2,;-2.57,-1.2,;-2.57,-2.73,;-1.22,-.4,;.11,-1.2,;.11,-2.73,;1.44,-3.5,;1.44,-5.03,;2.99,-5.03,;2.19,-6.39,;3.75,-6.39,;.11,-5.81,;.11,-7.36,;-1.22,-5.03,;-2.57,-5.81,;-1.22,-3.5,;-1.22,1.13,;-2.57,1.91,;.11,1.91,;1.44,1.13,;2.77,1.91,;4.1,1.13,;5.45,1.91,;6.78,1.13,;5.45,3.44,;4.1,4.21,;2.77,3.44,;1.44,4.21,;4.1,5.76,;2.77,6.52,;5.45,6.52,;.11,3.44,;1.64,3.44,;.44,4.9,;-.44,6.16,;.55,7.36,;-2.33,6.72,;-1.88,4.46,;-3.9,5.76,;-5.23,6.52,;-3.9,4.21,;-2.57,3.44,;-5.23,3.44,;-6.78,3.44,;-6.01,4.79,)| Show InChI InChI=1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 47.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc.
Curated by PDSP Ki Database
| |
Anal Biochem 300: 146-51 (2002)
Article DOI: 10.1006/abio.2001.5466
BindingDB Entry DOI: 10.7270/Q2NK3CM4 |
More data for this
Ligand-Target Pair | |
Promotilin
(Homo sapiens (Human)) | BDBM50127141
((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2R,3S,4R,...)Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H]([C@@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O |r| Show InChI InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19+,20+,21+,22-,23+,24-,25-,26+,28+,29+,30-,31+,32-,34-,35-,36-,37-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc.
Curated by PDSP Ki Database
| |
Anal Biochem 300: 146-51 (2002)
Article DOI: 10.1006/abio.2001.5466
BindingDB Entry DOI: 10.7270/Q2NK3CM4 |
More data for this
Ligand-Target Pair | |
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