Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM25117 (AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.418 | n/a | n/a | n/a | n/a | 7.5 | 25 |
PFIZER INC. US Patent | Assay Description Axitinib was tested using a Z′-LYTE Screening Protocol (Invitrogen, Carlsbad, Calif.). Axitinib was prepared in 100% DMSO, and added to the rea... | US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM25117 (AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.551 | n/a | n/a | n/a | n/a | 7.5 | 25 |
PFIZER INC. US Patent | Assay Description Axitinib was tested with the Caliper LabChip3000 assay (Caliper Life Science, Hopkinton, Mass.), which is a mobility-shift assay (MSA) that combines ... | US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM25117 (AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 7.5 | 25 |
PFIZER INC. US Patent | Assay Description Axitinib was tested using a Z′-LYTE Screening Protocol (Invitrogen, Carlsbad, Calif.). Axitinib was prepared in 100% DMSO, and added to the rea... | US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM25117 (AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 7.78 | n/a | n/a | n/a | n/a | 7.5 | 25 |
PFIZER INC. US Patent | Assay Description Axitinib was tested with the Caliper LabChip3000 assay (Caliper Life Science, Hopkinton, Mass.), which is a mobility-shift assay (MSA) that combines ... | US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG | |||||||||||
More data for this Ligand-Target Pair |