Compile Data Set for Download or QSAR

Found 96 hits Enz. Inhib. hit(s) with all data for entry = 7651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208487 (US9266870, 3) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19/h3-9,11,13-14,22H,2,10,12,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208519 (US9266870, 35) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C24H23FN6O2/c1-17-3-8-22(31-26-9-10-27-31)21(13-17)24(32)30-11-2-12-33-23(30)16-29-15-19(14-28-29)18-4-6-20(25)7-5-18/h3-10,13-15,23H,2,11-12,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208524 (US9266870, 40 | US9266870, 49) Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1 Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208511 (US9266870, 27) Show SMILES Cc1ccc(c(n1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O2/c1-15-2-7-19(30-24-9-10-25-30)21(26-15)22(31)29-12-13-32-20(29)14-28-11-8-18(27-28)16-3-5-17(23)6-4-16/h2-11,20H,12-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208519 (US9266870, 35) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C24H23FN6O2/c1-17-3-8-22(31-26-9-10-27-31)21(13-17)24(32)30-11-2-12-33-23(30)16-29-15-19(14-28-29)18-4-6-20(25)7-5-18/h3-10,13-15,23H,2,11-12,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208525 (US9266870, 41) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1 Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-21(25-28-11-2-12-29-25)22(16-18)26(33)32-13-3-15-34-24(32)17-31-14-10-23(30-31)19-5-7-20(27)8-6-19/h2,4-12,14,16,24H,3,13,15,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208525 (US9266870, 41) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1 Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-21(25-28-11-2-12-29-25)22(16-18)26(33)32-13-3-15-34-24(32)17-31-14-10-23(30-31)19-5-7-20(27)8-6-19/h2,4-12,14,16,24H,3,13,15,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208521 (US9266870, 37) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C23H21FN6O3/c1-15-3-8-19(30-25-9-10-26-30)18(13-15)23(31)29-11-2-12-32-21(29)14-20-27-22(33-28-20)16-4-6-17(24)7-5-16/h3-10,13,21H,2,11-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208513 (US9266870, 29) Show SMILES Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H23FN6O2/c1-17-4-9-20(24-27-11-2-12-28-24)23(29-17)25(33)32-13-3-15-34-22(32)16-31-14-10-21(30-31)18-5-7-19(26)8-6-18/h2,4-12,14,22H,3,13,15-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208487 (US9266870, 3) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19/h3-9,11,13-14,22H,2,10,12,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208524 (US9266870, 40 | US9266870, 49) Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1 Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208521 (US9266870, 37) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C23H21FN6O3/c1-15-3-8-19(30-25-9-10-26-30)18(13-15)23(31)29-11-2-12-32-21(29)14-20-27-22(33-28-20)16-4-6-17(24)7-5-16/h3-10,13,21H,2,11-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208522 (US9266870, 38) Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O3/c1-14-3-8-17(30-24-9-10-25-30)20(26-14)22(31)29-11-2-12-32-19(29)13-18-27-21(33-28-18)15-4-6-16(23)7-5-15/h3-10,19H,2,11-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208518 (US9266870, 34) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1 Show InChI InChI=1S/C24H20F2N6O2/c25-16-3-5-18(23-27-8-1-9-28-23)19(13-16)24(33)32-10-2-12-34-22(32)15-31-11-7-21(30-31)20-6-4-17(26)14-29-20/h1,3-9,11,13-14,22H,2,10,12,15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208512 (US9266870, 28) Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-8-20(31-25-10-11-26-31)22(27-16)23(32)30-12-2-14-33-21(30)15-29-13-9-19(28-29)17-4-6-18(24)7-5-17/h3-11,13,21H,2,12,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208527 (US9266870, 43) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-c1ncccn1 Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-22(25-28-10-2-11-29-25)23(14-18)26(33)32-12-3-13-34-24(32)17-31-16-20(15-30-31)19-5-7-21(27)8-6-19/h2,4-11,14-16,24H,3,12-13,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208514 (US9266870, 30) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1 Show InChI InChI=1S/C22H19F2N7O2/c23-15-3-5-20(31-26-7-8-27-31)17(12-15)22(32)30-9-1-11-33-21(30)14-29-10-6-19(28-29)18-4-2-16(24)13-25-18/h2-8,10,12-13,21H,1,9,11,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208529 (US9266870, 45) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cc1ccn(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O2/c1-15-2-4-19(30-25-7-8-26-30)18(12-15)22(31)28-10-11-32-21(28)13-17-6-9-29(27-17)20-5-3-16(23)14-24-20/h2-9,12,14,21H,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208514 (US9266870, 30) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1 Show InChI InChI=1S/C22H19F2N7O2/c23-15-3-5-20(31-26-7-8-27-31)17(12-15)22(32)30-9-1-11-33-21(30)14-29-10-6-19(28-29)18-4-2-16(24)13-25-18/h2-8,10,12-13,21H,1,9,11,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208511 (US9266870, 27) Show SMILES Cc1ccc(c(n1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O2/c1-15-2-7-19(30-24-9-10-25-30)21(26-15)22(31)29-12-13-32-20(29)14-28-11-8-18(27-28)16-3-5-17(23)6-4-16/h2-11,20H,12-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208488 (US9266870, 4) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-7-8-27-31)19(11-16)23(32)30-9-2-10-33-22(30)15-29-14-17(12-28-29)20-5-4-18(24)13-25-20/h3-8,11-14,22H,2,9-10,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208513 (US9266870, 29) Show SMILES Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H23FN6O2/c1-17-4-9-20(24-27-11-2-12-28-24)23(29-17)25(33)32-13-3-15-34-22(32)16-31-14-10-21(30-31)18-5-7-19(26)8-6-18/h2,4-12,14,22H,3,13,15-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208527 (US9266870, 43) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-c1ncccn1 Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-22(25-28-10-2-11-29-25)23(14-18)26(33)32-12-3-13-34-24(32)17-31-16-20(15-30-31)19-5-7-21(27)8-6-19/h2,4-11,14-16,24H,3,12-13,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208531 (US9266870, 47) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-5-20(31-26-7-8-27-31)19(11-16)23(32)29-9-2-10-33-22(29)12-17-13-28-30(15-17)21-6-4-18(24)14-25-21/h3-8,11,13-15,22H,2,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208531 (US9266870, 47) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-5-20(31-26-7-8-27-31)19(11-16)23(32)29-9-2-10-33-22(29)12-17-13-28-30(15-17)21-6-4-18(24)14-25-21/h3-8,11,13-15,22H,2,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208520 (US9266870, 36) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O3/c1-14-3-6-18(30-25-7-8-26-30)16(11-14)22(31)29-9-2-10-32-20(29)12-19-27-21(33-28-19)17-5-4-15(23)13-24-17/h3-8,11,13,20H,2,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208512 (US9266870, 28) Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-8-20(31-25-10-11-26-31)22(27-16)23(32)30-12-2-14-33-21(30)15-29-13-9-19(28-29)17-4-6-18(24)7-5-17/h3-11,13,21H,2,12,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208485 (US9266870, 1) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O2/c1-15-2-5-20(30-25-7-8-26-30)17(12-15)22(31)29-10-11-32-21(29)14-28-9-6-19(27-28)18-4-3-16(23)13-24-18/h2-9,12-13,21H,10-11,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208518 (US9266870, 34) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1 Show InChI InChI=1S/C24H20F2N6O2/c25-16-3-5-18(23-27-8-1-9-28-23)19(13-16)24(33)32-10-2-12-34-22(32)15-31-11-7-21(30-31)20-6-4-17(26)14-29-20/h1,3-9,11,13-14,22H,2,10,12,15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208520 (US9266870, 36) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O3/c1-14-3-6-18(30-25-7-8-26-30)16(11-14)22(31)29-9-2-10-32-20(29)12-19-27-21(33-28-19)17-5-4-15(23)13-24-17/h3-8,11,13,20H,2,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208491 (US9266870, 7) Show SMILES C[C@@H]1CO[C@@H](Cn2ccc(n2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1 |r| Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-8-9-27-31)18(11-15)23(32)30-16(2)14-33-22(30)13-29-10-7-20(28-29)19-5-4-17(24)12-25-19/h3-12,16,22H,13-14H2,1-2H3/t16-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.20	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208515 (US9266870, 31) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1 Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-19(24-27-9-2-10-28-24)20(14-17)25(33)32-11-3-13-34-23(32)16-31-12-8-22(30-31)21-7-5-18(26)15-29-21/h2,4-10,12,14-15,23H,3,11,13,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208522 (US9266870, 38) Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O3/c1-14-3-8-17(30-24-9-10-25-30)20(26-14)22(31)29-11-2-12-32-19(29)13-18-27-21(33-28-18)15-4-6-16(23)7-5-15/h3-10,19H,2,11-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208524 (US9266870, 40 | US9266870, 49) Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1 Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208524 (US9266870, 40 | US9266870, 49) Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1 Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.30	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208498 (US9266870, 14) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1 |w:13.15| Show InChI InChI=1S/C24H21FN6O2/c1-16-3-5-18(23-26-8-2-9-27-23)19(13-16)24(32)31-11-12-33-22(31)15-30-10-7-21(29-30)20-6-4-17(25)14-28-20/h2-10,13-14,22H,11-12,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208488 (US9266870, 4) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-7-8-27-31)19(11-16)23(32)30-9-2-10-33-22(30)15-29-14-17(12-28-29)20-5-4-18(24)13-25-20/h3-8,11-14,22H,2,9-10,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208498 (US9266870, 14) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1 |w:13.15| Show InChI InChI=1S/C24H21FN6O2/c1-16-3-5-18(23-26-8-2-9-27-23)19(13-16)24(32)31-11-12-33-22(31)15-30-10-7-21(29-30)20-6-4-17(25)14-28-20/h2-10,13-14,22H,11-12,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208490 (US9266870, 6) Show SMILES C[C@@H]1CN([C@H](Cn2cc(cn2)-c2ccc(F)cn2)O1)C(=O)c1cc(C)ccc1-n1nccn1 |r| Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-12-16(2)33-22(30)14-29-13-17(10-28-29)20-5-4-18(24)11-25-20/h3-11,13,16,22H,12,14H2,1-2H3/t16-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.80	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208515 (US9266870, 31) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1 Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-19(24-27-9-2-10-28-24)20(14-17)25(33)32-11-3-13-34-23(32)16-31-12-8-22(30-31)21-7-5-18(26)15-29-21/h2,4-10,12,14-15,23H,3,11,13,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.9	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208489 (US9266870, 5) Show SMILES C[C@H]1CN([C@H](Cn2cc(cn2)-c2ccc(F)cn2)O1)C(=O)c1cc(C)ccc1-n1nccn1 |r| Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-12-16(2)33-22(30)14-29-13-17(10-28-29)20-5-4-18(24)11-25-20/h3-11,13,16,22H,12,14H2,1-2H3/t16-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.5	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208529 (US9266870, 45) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cc1ccn(n1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O2/c1-15-2-4-19(30-25-7-8-26-30)18(12-15)22(31)28-10-11-32-21(28)13-17-6-9-29(27-17)20-5-3-16(23)14-24-20/h2-9,12,14,21H,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208504 (US9266870, 20) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1 |w:13.15| Show InChI InChI=1S/C25H22FN5O2/c1-17-3-8-20(24-27-10-2-11-28-24)21(15-17)25(32)31-13-14-33-23(31)16-30-12-9-22(29-30)18-4-6-19(26)7-5-18/h2-12,15,23H,13-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.3	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208486 (US9266870, 2) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1 Show InChI InChI=1S/C22H20FN7O2/c1-15-2-5-20(30-25-6-7-26-30)18(10-15)22(31)29-8-9-32-21(29)14-28-13-16(11-27-28)19-4-3-17(23)12-24-19/h2-7,10-13,21H,8-9,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.3	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208499 (US9266870, 15) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-c2ncccn2)n1 |w:12.12| Show InChI InChI=1S/C23H19FN6O2/c24-16-6-7-19(27-14-16)20-8-11-29(28-20)15-21-30(12-13-32-21)23(31)18-5-2-1-4-17(18)22-25-9-3-10-26-22/h1-11,14,21H,12-13,15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.9	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208526 (US9266870, 42) Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-c1ncccn1 |w:14.16| Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-20(24-27-8-2-9-28-24)21(12-17)25(33)31-10-3-11-34-23(31)13-18-14-30-32(16-18)22-7-5-19(26)15-29-22/h2,4-9,12,14-16,23H,3,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.2	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208495 (US9266870, 11) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1 |w:12.12| Show InChI InChI=1S/C21H18FN7O2/c22-15-5-6-17(23-13-15)18-7-10-27(26-18)14-20-28(11-12-31-20)21(30)16-3-1-2-4-19(16)29-24-8-9-25-29/h1-10,13,20H,11-12,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.5	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair

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