Compile Data Set for Download or QSAR

Found 119 hits Enz. Inhib. hit(s) with all data for entry = 7973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226282 (US9321790, 94) Show SMILES CC(=O)N1CCC(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:15:19:24.25:22| Show InChI InChI=1S/C21H28F3N5O3/c1-13(30)26-5-2-14(3-6-26)10-29-17(21(22,23)24)4-7-27-19(31)9-18(25-20(27)29)28-11-16-8-15(28)12-32-16/h9,14-17H,2-8,10-12H2,1H3/t15-,16-,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226283 (US9321790, 95) Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC1CCN(CC1)C=O |THB:10:14:20.19:17| Show InChI InChI=1S/C20H26F3N5O3/c21-20(22,23)16-3-6-26-18(30)8-17(27-10-15-7-14(27)11-31-15)24-19(26)28(16)9-13-1-4-25(12-29)5-2-13/h8,12-16H,1-7,9-11H2/t14-,15-,16?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226271 (US9321790, 83) Show SMILES Oc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)cc1 |TLB:14:18:21.22:25| Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)18-8-10-29-20(31)11-19(27-12-16-5-6-17(13-27)32-16)26-21(29)28(18)9-7-14-1-3-15(30)4-2-14/h1-4,11,16-18,30H,5-10,12-13H2/t16?,17?,18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226272 (US9321790, 84) Show SMILES Cc1c(nc2N(CCCc3ccccc3)[C@@H](CCn2c1=O)C(F)(F)F)N1CC2CCC(C1)O2 |TLB:2:25:28.29:32| Show InChI InChI=1S/C24H29F3N4O2/c1-16-21(29-14-18-9-10-19(15-29)33-18)28-23-30(12-5-8-17-6-3-2-4-7-17)20(24(25,26)27)11-13-31(23)22(16)32/h2-4,6-7,18-20H,5,8-15H2,1H3/t18?,19?,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226266 (US9321790, 78) Show SMILES CN(C)CCCOc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:16:28:31.32:35| Show InChI InChI=1S/C27H36F3N5O3/c1-26(27(28,29)30)18-34-24(36)15-23(33-16-21-9-10-22(17-33)38-21)31-25(34)35(26)13-11-19-5-7-20(8-6-19)37-14-4-12-32(2)3/h5-8,15,21-22H,4,9-14,16-18H2,1-3H3/t21?,22?,26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226299 (US9321790, 111) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(OCCN2CCOCC2)cc1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C27H34F3N5O4/c28-27(29,30)23-6-8-34-25(36)16-24(35-17-22-15-20(35)18-39-22)31-26(34)33(23)7-5-19-1-3-21(4-2-19)38-14-11-32-9-12-37-13-10-32/h1-4,16,20,22-23H,5-15,17-18H2/t20-,22-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	330	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226270 (US9321790, 82) Show SMILES O[C@H](CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F)c1cc2ccccc2s1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C24H25F3N4O3S/c25-24(26,27)20-7-8-30-22(33)10-21(29-11-15-5-6-16(12-29)34-15)28-23(30)31(20)13-17(32)19-9-14-3-1-2-4-18(14)35-19/h1-4,9-10,15-17,20,32H,5-8,11-13H2/t15?,16?,17-,20+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	340	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226305 (US9321790, 117) Show SMILES CN(C)CCOc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)cc1 |TLB:19:23:28.29:26| Show InChI InChI=1S/C25H32F3N5O3/c1-30(2)11-12-35-19-5-3-17(4-6-19)7-9-31-21(25(26,27)28)8-10-32-23(34)14-22(29-24(31)32)33-15-20-13-18(33)16-36-20/h3-6,14,18,20-21H,7-13,15-16H2,1-2H3/t18-,20-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226285 (US9321790, 97) Show SMILES OC(CCN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C(F)(F)F)C(F)(F)F |THB:11:15:21.20:18| Show InChI InChI=1S/C18H19F9N4O3/c19-16(20,21)11-1-3-30-13(32)6-12(31-7-10-5-9(31)8-34-10)28-14(30)29(11)4-2-15(33,17(22,23)24)18(25,26)27/h6,9-11,33H,1-5,7-8H2/t9-,10-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	440	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226280 (US9321790, 92) Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCC1CCOCC1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H27F3N4O3/c21-20(22,23)16-2-6-26-18(28)10-17(27-11-15-9-14(27)12-30-15)24-19(26)25(16)5-1-13-3-7-29-8-4-13/h10,13-16H,1-9,11-12H2/t14-,15-,16?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226289 (US9321790, 101) Show SMILES OC1(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CCCC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C19H25F3N4O3/c20-19(21,22)14-3-6-24-16(27)8-15(25-9-13-7-12(25)10-29-13)23-17(24)26(14)11-18(28)4-1-2-5-18/h8,12-14,28H,1-7,9-11H2/t12-,13-,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226303 (US9321790, 115) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(OCC(=O)N2CCOCC2)cc1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C27H32F3N5O5/c28-27(29,30)22-6-8-34-24(36)14-23(35-15-21-13-19(35)16-39-21)31-26(34)33(22)7-5-18-1-3-20(4-2-18)40-17-25(37)32-9-11-38-12-10-32/h1-4,14,19,21-22H,5-13,15-17H2/t19-,21-,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	590	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226260 (US9321790, 72) Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CCc1ccc(O)cc1)C(F)(F)F |TLB:6:10:13.14:17| Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(31)10-18(27-11-16-6-7-17(12-27)32-16)26-20(28)29(21)9-8-14-2-4-15(30)5-3-14/h2-5,10,16-17,30H,6-9,11-13H2,1H3/t16?,17?,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	730	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226281 (US9321790, 93) Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC1CCOCC1 |THB:10:14:20.19:17| Show InChI InChI=1S/C19H25F3N4O3/c20-19(21,22)15-1-4-24-17(27)8-16(25-10-14-7-13(25)11-29-14)23-18(24)26(15)9-12-2-5-28-6-3-12/h8,12-15H,1-7,9-11H2/t13-,14-,15?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226259 (US9321790, 71) Show SMILES COc1cc(F)ccc1[C@H](O)CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F |TLB:19:23:26.27:30| Show InChI InChI=1S/C23H26F4N4O4/c1-34-18-8-13(24)2-5-16(18)17(32)12-31-19(23(25,26)27)6-7-30-21(33)9-20(28-22(30)31)29-10-14-3-4-15(11-29)35-14/h2,5,8-9,14-15,17,19,32H,3-4,6-7,10-12H2,1H3/t14?,15?,17-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	810	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226265 (US9321790, 77) Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CCCc1ccccc1)C(F)(F)F |TLB:6:10:13.14:17| Show InChI InChI=1S/C23H27F3N4O2/c1-22(23(24,25)26)15-29-20(31)12-19(28-13-17-9-10-18(14-28)32-17)27-21(29)30(22)11-5-8-16-6-3-2-4-7-16/h2-4,6-7,12,17-18H,5,8-11,13-15H2,1H3/t17?,18?,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	820	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226262 (US9321790, 74) Show SMILES CN(C)CCOc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:15:27:30.31:34| Show InChI InChI=1S/C26H34F3N5O3/c1-25(26(27,28)29)17-33-23(35)14-22(32-15-20-8-9-21(16-32)37-20)30-24(33)34(25)11-10-18-4-6-19(7-5-18)36-13-12-31(2)3/h4-7,14,20-21H,8-13,15-17H2,1-3H3/t20?,21?,25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	820	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226291 (US9321790, 103) Show SMILES OC(CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C1CC1)C1CC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C21H27F3N4O3/c22-21(23,24)16-5-6-26-18(29)8-17(27-9-15-7-14(27)10-31-15)25-19(26)28(16)11-20(30,12-1-2-12)13-3-4-13/h8,12-16,30H,1-7,9-11H2/t14-,15-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	840	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226292 (US9321790, 104) Show SMILES OC1(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C17H21F3N4O3/c18-17(19,20)12-1-4-22-14(25)6-13(23-7-11-5-10(23)8-27-11)21-15(22)24(12)9-16(26)2-3-16/h6,10-12,26H,1-5,7-9H2/t10-,11-,12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	930	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226264 (US9321790, 76) Show SMILES COc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:11:23:26.27:30| Show InChI InChI=1S/C23H27F3N4O3/c1-22(23(24,25)26)14-29-20(31)11-19(28-12-17-7-8-18(13-28)33-17)27-21(29)30(22)10-9-15-3-5-16(32-2)6-4-15/h3-6,11,17-18H,7-10,12-14H2,1-2H3/t17?,18?,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	950	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226258 (US9321790, 70) Show SMILES CN(C)C(=O)COc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:16:28:31.32:35| Show InChI InChI=1S/C26H32F3N5O4/c1-25(26(27,28)29)16-33-22(35)12-21(32-13-19-8-9-20(14-32)38-19)30-24(33)34(25)11-10-17-4-6-18(7-5-17)37-15-23(36)31(2)3/h4-7,12,19-20H,8-11,13-16H2,1-3H3/t19?,20?,25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226213 (US9321790, 25) Show SMILES Cc1ncsc1CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:15:19:24.25:22| Show InChI InChI=1S/C19H22F3N5O2S/c1-11-14(30-10-23-11)2-4-25-15(19(20,21)22)3-5-26-17(28)7-16(24-18(25)26)27-8-13-6-12(27)9-29-13/h7,10,12-13,15H,2-6,8-9H2,1H3/t12-,13-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226211 (US9321790, 23) Show SMILES CCNC(=O)Nc1ccc(CCN2C(CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)cc1 |TLB:19:23:28.29:26| Show InChI InChI=1S/C24H29F3N6O3/c1-2-28-22(35)29-16-5-3-15(4-6-16)7-9-31-19(24(25,26)27)8-10-32-21(34)12-20(30-23(31)32)33-13-18-11-17(33)14-36-18/h3-6,12,17-19H,2,7-11,13-14H2,1H3,(H2,28,29,35)/t17-,18-,19?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226276 (US9321790, 88) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccccn1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-6-8-28-19(31)9-18(27-10-13-4-5-14(11-27)32-13)26-20(28)29(17)12-16(30)15-3-1-2-7-25-15/h1-3,7,9,13-14,17H,4-6,8,10-12H2/t13?,14?,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226215 (US9321790, 27) Show SMILES Cc1n[nH]c(C)c1CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C20H25F3N6O2/c1-11-15(12(2)26-25-11)3-5-27-16(20(21,22)23)4-6-28-18(30)8-17(24-19(27)28)29-9-14-7-13(29)10-31-14/h8,13-14,16H,3-7,9-10H2,1-2H3,(H,25,26)/t13-,14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226267 (US9321790, 79) Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1C[C@@H](O)c1ccccc1)C(F)(F)F |TLB:6:10:13.14:17| Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(31)9-18(27-10-15-7-8-16(11-27)32-15)26-20(28)29(21)12-17(30)14-5-3-2-4-6-14/h2-6,9,15-17,30H,7-8,10-13H2,1H3/t15?,16?,17-,21+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226268 (US9321790, 80) Show SMILES O[C@H](CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F)c1ccccc1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)18-8-9-28-20(31)10-19(27-11-15-6-7-16(12-27)32-15)26-21(28)29(18)13-17(30)14-4-2-1-3-5-14/h1-5,10,15-18,30H,6-9,11-13H2/t15?,16?,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226293 (US9321790, 105) Show SMILES OC1(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C18H23F3N4O3/c19-18(20,21)13-1-5-24-15(26)8-14(25-9-12-7-11(25)10-28-12)22-16(24)23(13)6-4-17(27)2-3-17/h8,11-13,27H,1-7,9-10H2/t11-,12-,13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226288 (US9321790, 100) Show SMILES OC1(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CCCC1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C20H27F3N4O3/c21-20(22,23)15-3-7-26-17(28)10-16(27-11-14-9-13(27)12-30-14)24-18(26)25(15)8-6-19(29)4-1-2-5-19/h10,13-15,29H,1-9,11-12H2/t13-,14-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226214 (US9321790, 26) Show SMILES Cc1ncsc1CCN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:11:23:28.29:26| Show InChI InChI=1S/C19H22F3N5O2S/c1-11-14(30-10-23-11)3-4-27-17-24-15(25-7-13-5-12(25)8-29-13)6-16(28)26(17)9-18(27,2)19(20,21)22/h6,10,12-13H,3-5,7-9H2,1-2H3/t12-,13-,18?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226269 (US9321790, 81) Show SMILES COc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)cc1 |TLB:15:19:22.23:26| Show InChI InChI=1S/C23H27F3N4O3/c1-32-16-4-2-15(3-5-16)8-10-29-19(23(24,25)26)9-11-30-21(31)12-20(27-22(29)30)28-13-17-6-7-18(14-28)33-17/h2-5,12,17-19H,6-11,13-14H2,1H3/t17?,18?,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226242 (US9321790, 54) Show SMILES CCC(O)(CC)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:14:18:23.24:21| Show InChI InChI=1S/C19H27F3N4O3/c1-3-18(28,4-2)11-26-14(19(20,21)22)5-6-24-16(27)8-15(23-17(24)26)25-9-13-7-12(25)10-29-13/h8,12-14,28H,3-7,9-11H2,1-2H3/t12-,13-,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226216 (US9321790, 28) Show SMILES Cc1n[nH]c(C)c1CCN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:12:24:29.30:27| Show InChI InChI=1S/C20H25F3N6O2/c1-11-15(12(2)26-25-11)4-5-29-18-24-16(27-8-14-6-13(27)9-31-14)7-17(30)28(18)10-19(29,3)20(21,22)23/h7,13-14H,4-6,8-10H2,1-3H3,(H,25,26)/t13-,14-,19?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.26E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226278 (US9321790, 90) Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCC1CCN(CC1)C=O |THB:10:14:20.19:17| Show InChI InChI=1S/C21H28F3N5O3/c22-21(23,24)17-4-8-28-19(31)10-18(29-11-16-9-15(29)12-32-16)25-20(28)27(17)7-3-14-1-5-26(13-30)6-2-14/h10,13-17H,1-9,11-12H2/t15-,16-,17?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226212 (US9321790, 24) Show SMILES CCNC(=O)Nc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2C[C@@H]3C[C@H]2CO3)cc1 |TLB:15:27:32.33:30| Show InChI InChI=1S/C24H29F3N6O3/c1-3-28-21(35)29-16-6-4-15(5-7-16)8-9-33-22-30-19(31-12-18-10-17(31)13-36-18)11-20(34)32(22)14-23(33,2)24(25,26)27/h4-7,11,17-18H,3,8-10,12-14H2,1-2H3,(H2,28,29,35)/t17-,18-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226261 (US9321790, 73) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccccc1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C22H23F3N4O3/c23-22(24,25)18-8-9-28-20(31)10-19(27-11-15-6-7-16(12-27)32-15)26-21(28)29(18)13-17(30)14-4-2-1-3-5-14/h1-5,10,15-16,18H,6-9,11-13H2/t15?,16?,18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226290 (US9321790, 102) Show SMILES OC(CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C1CC1)C1CC1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C22H29F3N4O3/c23-22(24,25)17-5-7-28-19(30)10-18(29-11-16-9-15(29)12-32-16)26-20(28)27(17)8-6-21(31,13-1-2-13)14-3-4-14/h10,13-17,31H,1-9,11-12H2/t15-,16-,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226237 (US9321790, 49) Show SMILES CCC(O)(CC)CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:15:19:24.25:22| Show InChI InChI=1S/C20H29F3N4O3/c1-3-19(29,4-2)6-8-25-15(20(21,22)23)5-7-26-17(28)10-16(24-18(25)26)27-11-14-9-13(27)12-30-14/h10,13-15,29H,3-9,11-12H2,1-2H3/t13-,14-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226277 (US9321790, 89) Show SMILES CC(=O)N1CCC(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:16:20:25.26:23| Show InChI InChI=1S/C22H30F3N5O3/c1-14(31)27-6-2-15(3-7-27)4-8-28-18(22(23,24)25)5-9-29-20(32)11-19(26-21(28)29)30-12-17-10-16(30)13-33-17/h11,15-18H,2-10,12-13H2,1H3/t16-,17-,18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226200 (US9321790, 12) Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1cccnc1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H22F3N5O2/c21-20(22,23)16-4-7-27-18(29)9-17(28-11-15-8-14(28)12-30-15)25-19(27)26(16)6-3-13-2-1-5-24-10-13/h1-2,5,9-10,14-16H,3-4,6-8,11-12H2/t14-,15-,16?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226189 (US9321790, 1) Show SMILES CC(C)(CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)c1ccncc1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C22H26F3N5O2/c1-21(2,14-3-6-26-7-4-14)13-30-17(22(23,24)25)5-8-28-19(31)10-18(27-20(28)30)29-11-16-9-15(29)12-32-16/h3-4,6-7,10,15-17H,5,8-9,11-13H2,1-2H3/t15-,16-,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.13E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226220 (US9321790, 32) Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(N)cc1)C(F)(F)F |TLB:6:10:15.16:13| Show InChI InChI=1S/C21H24F3N5O2/c1-20(21(22,23)24)12-28-18(30)9-17(27-10-16-8-15(27)11-31-16)26-19(28)29(20)7-6-13-2-4-14(25)5-3-13/h2-5,9,15-16H,6-8,10-12,25H2,1H3/t15-,16-,20?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226255 (US9321790, 67) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C18H21F3N4O3/c19-18(20,21)14-3-4-23-16(27)6-15(24-7-12-5-11(24)9-28-12)22-17(23)25(14)8-13(26)10-1-2-10/h6,10-12,14H,1-5,7-9H2/t11-,12-,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226229 (US9321790, 41) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(cc1)N1CCOCC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C25H28F3N5O4/c26-25(27,28)21-5-6-31-23(35)12-22(32-13-19-11-18(32)15-37-19)29-24(31)33(21)14-20(34)16-1-3-17(4-2-16)30-7-9-36-10-8-30/h1-4,12,18-19,21H,5-11,13-15H2/t18-,19-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226238 (US9321790, 50) Show SMILES CC(C)(O)CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:13:17:22.23:20| Show InChI InChI=1S/C18H25F3N4O3/c1-17(2,27)4-6-23-13(18(19,20)21)3-5-24-15(26)8-14(22-16(23)24)25-9-12-7-11(25)10-28-12/h8,11-13,27H,3-7,9-10H2,1-2H3/t11-,12-,13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226201 (US9321790, 13) Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1cccnc1)C(F)(F)F |TLB:6:10:15.16:13| Show InChI InChI=1S/C20H22F3N5O2/c1-19(20(21,22)23)12-27-17(29)8-16(26-10-15-7-14(26)11-30-15)25-18(27)28(19)6-4-13-3-2-5-24-9-13/h2-3,5,8-9,14-15H,4,6-7,10-12H2,1H3/t14-,15-,19?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.75E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226226 (US9321790, 38) Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cnc2NCCOc2c1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C22H23F3N6O4/c23-22(24,25)17-1-3-29-19(33)7-18(30-9-14-6-13(30)11-35-14)28-21(29)31(17)10-15(32)12-5-16-20(27-8-12)26-2-4-34-16/h5,7-8,13-14,17H,1-4,6,9-11H2,(H,26,27)/t13-,14-,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.77E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226219 (US9321790, 31) Show SMILES Cc1cc(cnc1N)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:18:22:27.28:25| Show InChI InChI=1S/C21H23F3N6O3/c1-11-4-12(7-26-19(11)25)15(31)9-30-16(21(22,23)24)2-3-28-18(32)6-17(27-20(28)30)29-8-14-5-13(29)10-33-14/h4,6-7,13-14,16H,2-3,5,8-10H2,1H3,(H2,25,26)/t13-,14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.35E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226246 (US9321790, 58) Show SMILES COC(=O)Nc1ccc(cn1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:21:25:30.31:28| Show InChI InChI=1S/C22H23F3N6O5/c1-35-21(34)27-17-3-2-12(8-26-17)15(32)10-31-16(22(23,24)25)4-5-29-19(33)7-18(28-20(29)31)30-9-14-6-13(30)11-36-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3,(H,26,27,34)/t13-,14-,16?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM226256 (US9321790, 68) Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccccn1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-4-6-26-18(30)8-17(27-9-13-7-12(27)11-31-13)25-19(26)28(16)10-15(29)14-3-1-2-5-24-14/h1-3,5,8,12-13,16H,4,6-7,9-11H2/t12-,13-,16?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	7.5	n/a
Sanofi US Patent					Assay Description The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...				US Patent US9321790 (2016) BindingDB Entry DOI: 10.7270/Q2KD1WSG
					More data for this Ligand-Target Pair

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