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Compile Data Set for Download or QSAR

Found 328 hits Enz. Inhib. hit(s) with all data for entry = 113   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176402
PNG
(US9688710, 1 (E)-3-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C28H36N2O5S/c1-18-4-10-21(27-25(33)24(32)26(34)28(35-27)36-3)17-22(18)16-20-7-5-19(6-8-20)9-11-23(31)30-14-12-29(2)13-15-30/h4-11,17,24-28,32-34H,12-16H2,1-3H3/b11-9+/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176403
PNG
(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H27ClO7S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176404
PNG
(US9688710, 3 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H28ClNO6S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H2,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176404
PNG
(US9688710, 3 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H28ClNO6S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H2,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176405
PNG
(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(O)CO)cc2)c1 |r|
Show InChI InChI=1S/C23H30O7S/c1-13-3-6-15(22-20(27)19(26)21(28)23(30-22)31-2)10-16(13)9-14-4-7-18(8-5-14)29-12-17(25)11-24/h3-8,10,17,19-28H,9,11-12H2,1-2H3/t17?,19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176406
PNG
(US9688710, 5 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-...)
Show SMILES COCCOCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C24H31ClO7S/c1-29-9-10-30-11-12-31-18-6-3-15(4-7-18)13-17-14-16(5-8-19(17)25)23-21(27)20(26)22(28)24(32-23)33-2/h3-8,14,20-24,26-28H,9-13H2,1-2H3/t20-,21-,22+,23+,24-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176407
PNG
(US9688710, 6 N-(1-hydroxy-2-methylpropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO6S/c1-17-8-13-20(26-24(33)23(32)25(34)27(35-26)36-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)29-28(2,3)16-30/h8-13,15,23-27,30,32-34H,5-7,14,16H2,1-4H3,(H,29,31)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176407
PNG
(US9688710, 6 N-(1-hydroxy-2-methylpropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO6S/c1-17-8-13-20(26-24(33)23(32)25(34)27(35-26)36-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)29-28(2,3)16-30/h8-13,15,23-27,30,32-34H,5-7,14,16H2,1-4H3,(H,29,31)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176408
PNG
(US9688710, 7 (S,E)-2-amino-5-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CC(N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C25H31NO6S/c1-14-6-11-17(23-21(28)20(27)22(29)25(32-23)33-2)13-18(14)12-16-9-7-15(8-10-16)4-3-5-19(26)24(30)31/h3-4,6-11,13,19-23,25,27-29H,5,12,26H2,1-2H3,(H,30,31)/b4-3+/t19?,20-,21-,22+,23+,25-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176409
PNG
(US9688710, 8 N-(1,3-dihydroxy-2-(hydroxymethyl)pro...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO8S/c1-17-6-11-20(26-24(35)23(34)25(36)27(37-26)38-2)13-21(17)12-19-9-7-18(8-10-19)4-3-5-22(33)29-28(14-30,15-31)16-32/h6-11,13,23-27,30-32,34-36H,3-5,12,14-16H2,1-2H3,(H,29,33)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176409
PNG
(US9688710, 8 N-(1,3-dihydroxy-2-(hydroxymethyl)pro...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO8S/c1-17-6-11-20(26-24(35)23(34)25(36)27(37-26)38-2)13-21(17)12-19-9-7-18(8-10-19)4-3-5-22(33)29-28(14-30,15-31)16-32/h6-11,13,23-27,30-32,34-36H,3-5,12,14-16H2,1-2H3,(H,29,33)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176410
PNG
(US9688710, 9 N-(1-amino-2-methyl-1-oxopropan-2-yl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O6S/c1-16-8-13-19(25-23(33)22(32)24(34)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(31)30-28(2,3)27(29)35/h8-13,15,22-26,32-34H,5-7,14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176410
PNG
(US9688710, 9 N-(1-amino-2-methyl-1-oxopropan-2-yl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O6S/c1-16-8-13-19(25-23(33)22(32)24(34)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(31)30-28(2,3)27(29)35/h8-13,15,22-26,32-34H,5-7,14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176411
PNG
(US9688710, 10 (2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzy...)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C22H28O5S/c1-4-26-17-9-6-14(7-10-17)11-16-12-15(8-5-13(16)2)21-19(24)18(23)20(25)22(27-21)28-3/h5-10,12,18-25H,4,11H2,1-3H3/t18-,19-,20+,21+,22-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176413
PNG
(US9688710, 12 2-(2-(4-(2-chloro-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C25H31ClN2O7S/c1-25(2,24(27)33)28-18(29)12-34-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)26)22-20(31)19(30)21(32)23(35-22)36-3/h4-9,11,19-23,30-32H,10,12H2,1-3H3,(H2,27,33)(H,28,29)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176414
PNG
(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-5)20-25(21)19-23-12-10-22(11-13-23)7-6-8-26(37)34-33(2,3)32(41)36-17-15-35(4)16-18-36/h9-14,20,27-31,38-40H,6-8,15-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176414
PNG
(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-5)20-25(21)19-23-12-10-22(11-13-23)7-6-8-26(37)34-33(2,3)32(41)36-17-15-35(4)16-18-36/h9-14,20,27-31,38-40H,6-8,15-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176415
PNG
(US9688710, 14 2-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C25H32ClNO9S/c1-37-24-22(34)20(32)21(33)23(36-24)15-4-7-18(26)16(9-15)8-14-2-5-17(6-3-14)35-10-19(31)27-25(11-28,12-29)13-30/h2-7,9,20-24,28-30,32-34H,8,10-13H2,1H3,(H,27,31)/t20-,21-,22+,23+,24-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176416
PNG
(US9688710, 15 2-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C30H40ClN3O7S/c1-30(2,29(39)34-13-11-33(3)12-14-34)32-23(35)17-40-21-8-5-18(6-9-21)15-20-16-19(7-10-22(20)31)27-25(37)24(36)26(38)28(41-27)42-4/h5-10,16,24-28,36-38H,11-15,17H2,1-4H3,(H,32,35)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176417
PNG
(US9688710, 16 (S)-2-amino-6-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C30H42N2O7S/c1-18-9-14-21(28-26(35)25(34)27(36)30(39-28)40-2)17-22(18)16-20-12-10-19(11-13-20)6-5-8-24(33)32-15-4-3-7-23(31)29(37)38/h9-14,17,23,25-28,30,34-36H,3-8,15-16,31H2,1-2H3,(H,32,33)(H,37,38)/t23-,25+,26+,27-,28-,30+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176417
PNG
(US9688710, 16 (S)-2-amino-6-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C30H42N2O7S/c1-18-9-14-21(28-26(35)25(34)27(36)30(39-28)40-2)17-22(18)16-20-12-10-19(11-13-20)6-5-8-24(33)32-15-4-3-7-23(31)29(37)38/h9-14,17,23,25-28,30,34-36H,3-8,15-16,31H2,1-2H3,(H,32,33)(H,37,38)/t23-,25+,26+,27-,28-,30+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176418
PNG
(US9688710, 17 (S)-2-amino-6-(2-(4-(2-chloro-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O8S/c1-16-6-9-18(26-24(33)23(32)25(34)28(38-26)39-2)14-19(16)13-17-7-10-20(11-8-17)37-15-22(31)30-12-4-3-5-21(29)27(35)36/h6-11,14,21,23-26,28,32-34H,3-5,12-13,15,29H2,1-2H3,(H,30,31)(H,35,36)/t21-,23+,24+,25-,26-,28+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176419
PNG
(US9688710, 18 (S)-2-amino-6-(4-(2-chloro-5-((2S,3R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC[C@H](N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C25H32ClNO7S/c1-35-25-22(30)20(28)21(29)23(34-25)15-7-10-18(26)16(13-15)12-14-5-8-17(9-6-14)33-11-3-2-4-19(27)24(31)32/h5-10,13,19-23,25,28-30H,2-4,11-12,27H2,1H3,(H,31,32)/t19-,20+,21+,22-,23-,25+/m0/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176420
PNG
(US9688710, 19 (E)-N-(1,3-dihydroxy-2-(hydroxymethy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H39NO8S/c1-18-7-12-21(27-25(36)24(35)26(37)28(38-27)39-2)14-22(18)13-20-10-8-19(9-11-20)5-3-4-6-23(34)30-29(15-31,16-32)17-33/h3,5,7-12,14,24-28,31-33,35-37H,4,6,13,15-17H2,1-2H3,(H,30,34)/b5-3+/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176420
PNG
(US9688710, 19 (E)-N-(1,3-dihydroxy-2-(hydroxymethy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H39NO8S/c1-18-7-12-21(27-25(36)24(35)26(37)28(38-27)39-2)14-22(18)13-20-10-8-19(9-11-20)5-3-4-6-23(34)30-29(15-31,16-32)17-33/h3,5,7-12,14,24-28,31-33,35-37H,4,6,13,15-17H2,1-2H3,(H,30,34)/b5-3+/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176421
PNG
(US9688710, 20 (E)-N-(1-amino-2-methyl-1-oxopropan-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H38N2O6S/c1-17-9-14-20(26-24(34)23(33)25(35)27(37-26)38-4)16-21(17)15-19-12-10-18(11-13-19)7-5-6-8-22(32)31-29(2,3)28(30)36/h5,7,9-14,16,23-27,33-35H,6,8,15H2,1-4H3,(H2,30,36)(H,31,32)/b7-5+/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176421
PNG
(US9688710, 20 (E)-N-(1-amino-2-methyl-1-oxopropan-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H38N2O6S/c1-17-9-14-20(26-24(34)23(33)25(35)27(37-26)38-4)16-21(17)15-19-12-10-18(11-13-19)7-5-6-8-22(32)31-29(2,3)28(30)36/h5,7,9-14,16,23-27,33-35H,6,8,15H2,1-4H3,(H2,30,36)(H,31,32)/b7-5+/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176422
PNG
(US9688710, 21 (E)-N-(2-methyl-1-(4-methylpiperazin...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C34H47N3O6S/c1-22-10-15-25(31-29(40)28(39)30(41)32(43-31)44-5)21-26(22)20-24-13-11-23(12-14-24)8-6-7-9-27(38)35-34(2,3)33(42)37-18-16-36(4)17-19-37/h6,8,10-15,21,28-32,39-41H,7,9,16-20H2,1-5H3,(H,35,38)/b8-6+/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176422
PNG
(US9688710, 21 (E)-N-(2-methyl-1-(4-methylpiperazin...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C34H47N3O6S/c1-22-10-15-25(31-29(40)28(39)30(41)32(43-31)44-5)21-26(22)20-24-13-11-23(12-14-24)8-6-7-9-27(38)35-34(2,3)33(42)37-18-16-36(4)17-19-37/h6,8,10-15,21,28-32,39-41H,7,9,16-20H2,1-5H3,(H,35,38)/b8-6+/t28-,29-,30+,31+,32-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176423
PNG
(US9688710, 22 N1,N3-bis(1-amino-2-methyl-1-oxoprop...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CC(=C)C(C(=O)NC(C)(C)C(N)=O)C(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C34H46N4O8S/c1-17-8-13-21(27-25(40)24(39)26(41)30(46-27)47-7)16-22(17)15-20-11-9-19(10-12-20)14-18(2)23(28(42)37-33(3,4)31(35)44)29(43)38-34(5,6)32(36)45/h8-13,16,23-27,30,39-41H,2,14-15H2,1,3-7H3,(H2,35,44)(H2,36,45)(H,37,42)(H,38,43)/t24-,25-,26+,27+,30-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176424
PNG
(US9688710, 23 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO8S/c1-18-7-12-21(27-25(36)24(35)26(37)28(38-27)39-2)14-22(18)13-20-10-8-19(9-11-20)5-3-4-6-23(34)30-29(15-31,16-32)17-33/h7-12,14,24-28,31-33,35-37H,3-6,13,15-17H2,1-2H3,(H,30,34)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176424
PNG
(US9688710, 23 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO8S/c1-18-7-12-21(27-25(36)24(35)26(37)28(38-27)39-2)14-22(18)13-20-10-8-19(9-11-20)5-3-4-6-23(34)30-29(15-31,16-32)17-33/h7-12,14,24-28,31-33,35-37H,3-6,13,15-17H2,1-2H3,(H,30,34)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176425
PNG
(US9688710, 24 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H40N2O6S/c1-17-9-14-20(26-24(34)23(33)25(35)27(37-26)38-4)16-21(17)15-19-12-10-18(11-13-19)7-5-6-8-22(32)31-29(2,3)28(30)36/h9-14,16,23-27,33-35H,5-8,15H2,1-4H3,(H2,30,36)(H,31,32)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176425
PNG
(US9688710, 24 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H40N2O6S/c1-17-9-14-20(26-24(34)23(33)25(35)27(37-26)38-4)16-21(17)15-19-12-10-18(11-13-19)7-5-6-8-22(32)31-29(2,3)28(30)36/h9-14,16,23-27,33-35H,5-8,15H2,1-4H3,(H2,30,36)(H,31,32)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176426
PNG
(US9688710, 25 5-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C30H42N2O5S/c1-20-8-13-23(29-27(35)26(34)28(36)30(37-29)38-3)19-24(20)18-22-11-9-21(10-12-22)6-4-5-7-25(33)32-16-14-31(2)15-17-32/h8-13,19,26-30,34-36H,4-7,14-18H2,1-3H3/t26-,27-,28+,29+,30-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176427
PNG
(US9688710, 26 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-4)20-25(21)19-23-12-10-22(11-13-23)7-5-6-8-26(37)35-33(2,3)32(41)36-17-15-34-16-18-36/h9-14,20,27-31,34,38-40H,5-8,15-19H2,1-4H3,(H,35,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176427
PNG
(US9688710, 26 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-4)20-25(21)19-23-12-10-22(11-13-23)7-5-6-8-26(37)35-33(2,3)32(41)36-17-15-34-16-18-36/h9-14,20,27-31,34,38-40H,5-8,15-19H2,1-4H3,(H,35,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176430
PNG
(US9688710, 29 (2S,3R,4R,5S,6R)-2-(3-(4-chlorobenzy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(Cl)cc2)c1 |r|
Show InChI InChI=1S/C20H23ClO4S/c1-11-3-6-13(10-14(11)9-12-4-7-15(21)8-5-12)19-17(23)16(22)18(24)20(25-19)26-2/h3-8,10,16-20,22-24H,9H2,1-2H3/t16-,17-,18+,19+,20-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176431
PNG
(US9688710, 30 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C29H40N2O5S/c1-19-7-12-22(28-26(34)25(33)27(35)29(36-28)37-3)18-23(19)17-21-10-8-20(9-11-21)5-4-6-24(32)31-15-13-30(2)14-16-31/h7-12,18,25-29,33-35H,4-6,13-17H2,1-3H3/t25-,26-,27+,28+,29-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176432
PNG
(US9688710, 31 (S)-2-amino-6-(5-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C31H44N2O7S/c1-19-10-15-22(29-27(36)26(35)28(37)31(40-29)41-2)18-23(19)17-21-13-11-20(12-14-21)7-3-4-9-25(34)33-16-6-5-8-24(32)30(38)39/h10-15,18,24,26-29,31,35-37H,3-9,16-17,32H2,1-2H3,(H,33,34)(H,38,39)/t24-,26+,27+,28-,29-,31+/m0/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176433
PNG
(US9688710, 32 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C27H36ClNO9S/c1-39-26-24(36)22(34)23(35)25(38-26)17-6-9-20(28)18(12-17)11-16-4-7-19(8-5-16)37-10-2-3-21(33)29-27(13-30,14-31)15-32/h4-9,12,22-26,30-32,34-36H,2-3,10-11,13-15H2,1H3,(H,29,33)/t22-,23-,24+,25+,26-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176434
PNG
(US9688710, 33 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O7S/c1-16-7-10-18(25-23(33)22(32)24(34)26(37-25)38-4)15-19(16)14-17-8-11-20(12-9-17)36-13-5-6-21(31)30-28(2,3)27(29)35/h7-12,15,22-26,32-34H,5-6,13-14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176434
PNG
(US9688710, 33 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O7S/c1-16-7-10-18(25-23(33)22(32)24(34)26(37-25)38-4)15-19(16)14-17-8-11-20(12-9-17)36-13-5-6-21(31)30-28(2,3)27(29)35/h7-12,15,22-26,32-34H,5-6,13-14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176437
PNG
(US9688710, 36 (S,R,S,R,R)-N,N′-((methylazane...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCN(C)CCCNC(=O)CCCc3ccc(Cc4cc(ccc4C)[C@@H]4O[C@H](SC)[C@@H](O)[C@H](O)[C@H]4O)cc3)cc2)c1 |r|
Show InChI InChI=1S/C55H75N3O10S2/c1-34-14-24-40(52-48(63)46(61)50(65)54(67-52)69-4)32-42(34)30-38-20-16-36(17-21-38)10-6-12-44(59)56-26-8-28-58(3)29-9-27-57-45(60)13-7-11-37-18-22-39(23-19-37)31-43-33-41(25-15-35(43)2)53-49(64)47(62)51(66)55(68-53)70-5/h14-25,32-33,46-55,61-66H,6-13,26-31H2,1-5H3,(H,56,59)(H,57,60)/t46-,47-,48-,49-,50+,51+,52+,53+,54-,55-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176437
PNG
(US9688710, 36 (S,R,S,R,R)-N,N′-((methylazane...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCN(C)CCCNC(=O)CCCc3ccc(Cc4cc(ccc4C)[C@@H]4O[C@H](SC)[C@@H](O)[C@H](O)[C@H]4O)cc3)cc2)c1 |r|
Show InChI InChI=1S/C55H75N3O10S2/c1-34-14-24-40(52-48(63)46(61)50(65)54(67-52)69-4)32-42(34)30-38-20-16-36(17-21-38)10-6-12-44(59)56-26-8-28-58(3)29-9-27-57-45(60)13-7-11-37-18-22-39(23-19-37)31-43-33-41(25-15-35(43)2)53-49(64)47(62)51(66)55(68-53)70-5/h14-25,32-33,46-55,61-66H,6-13,26-31H2,1-5H3,(H,56,59)(H,57,60)/t46-,47-,48-,49-,50+,51+,52+,53+,54-,55-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176438
PNG
(US9688710, 37 2-methyl-2-(2-(4-(2-methyl-5-((2S,3R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C26H34N2O7S/c1-14-5-8-16(23-21(31)20(30)22(32)24(35-23)36-4)12-17(14)11-15-6-9-18(10-7-15)34-13-19(29)28-26(2,3)25(27)33/h5-10,12,20-24,30-32H,11,13H2,1-4H3,(H2,27,33)(H,28,29)/t20-,21-,22+,23+,24-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176439
PNG
(US9688710, 38 2,2-dimethyl-3-(2-(4-(2-methyl-5-((2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(=O)NCC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H36N2O7S/c1-15-5-8-17(24-22(32)21(31)23(33)25(36-24)37-4)12-18(15)11-16-6-9-19(10-7-16)35-13-20(30)29-14-27(2,3)26(28)34/h5-10,12,21-25,31-33H,11,13-14H2,1-4H3,(H2,28,34)(H,29,30)/t21-,22-,23+,24+,25-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176440
PNG
(US9688710, 39 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H36N2O7S/c1-15-6-9-18(25-23(32)22(31)24(33)27(36-25)37-3)14-19(15)13-17-7-10-20(11-8-17)35-12-4-5-21(30)29-16(2)26(28)34/h6-11,14,16,22-25,27,31-33H,4-5,12-13H2,1-3H3,(H2,28,34)(H,29,30)/t16?,22-,23-,24+,25+,27-/m1/s1
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antibodypedia
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US Patent
n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
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