Found 12 hits Enz. Inhib. hit(s) with all data for entry = 50002268 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid receptor subunit gamma-1
(Rattus norvegicus) | BDBM50021185
(5-Aminomethyl-4,5-dihydro-isoxazol-3-ol | CHEMBL42...)Show InChI InChI=1S/C4H8N2O2/c5-2-3-1-4(7)6-8-3/h3H,1-2,5H2,(H,6,7)/t3-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-GABA binding to Gamma-aminobutyric-acid receptor of rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit gamma-1
(Rattus norvegicus) | BDBM23183
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-GABA binding to Gamma-aminobutyric-acid receptor of rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit gamma-1
(Rattus norvegicus) | BDBM24183
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-GABA binding to Gamma-aminobutyric-acid receptor of rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit gamma-1
(Rattus norvegicus) | BDBM50021189
(5-Aminomethyl-4,5-dihydro-isoxazol-3-ol | CHEMBL40...)Show InChI InChI=1S/C4H8N2O2/c5-2-3-1-4(7)6-8-3/h3H,1-2,5H2,(H,6,7)/t3-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-GABA binding to Gamma-aminobutyric-acid receptor of rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit gamma-1
(Rattus norvegicus) | BDBM50021186
(4-Amino-3-hydroxy-butyric acid | CHEMBL296263 | S(...)Show InChI InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-GABA binding to Gamma-aminobutyric-acid receptor of rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM24183
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50021186
(4-Amino-3-hydroxy-butyric acid | CHEMBL296263 | S(...)Show InChI InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50021187
(4-Amino-3-hydroxy-butyric acid | CHEMBL290216 | R(...)Show InChI InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vivo inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50021189
(5-Aminomethyl-4,5-dihydro-isoxazol-3-ol | CHEMBL40...)Show InChI InChI=1S/C4H8N2O2/c5-2-3-1-4(7)6-8-3/h3H,1-2,5H2,(H,6,7)/t3-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vivo inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50225363
(CHEMBL40363)Show InChI InChI=1S/C4H8N2O2/c5-2-3-1-4(7)6-8-3/h3H,1-2,5H2,(H,6,7) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM23183
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 3.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter
(Rattus norvegicus) | BDBM50021185
(5-Aminomethyl-4,5-dihydro-isoxazol-3-ol | CHEMBL42...)Show InChI InChI=1S/C4H8N2O2/c5-2-3-1-4(7)6-8-3/h3H,1-2,5H2,(H,6,7)/t3-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of GABA uptake in rat brain synaptic membranes |
J Med Chem 28: 1612-7 (1985)
BindingDB Entry DOI: 10.7270/Q2PN94NZ |
More data for this Ligand-Target Pair | |