Compile Data Set for Download or QSAR

Found 102 hits Enz. Inhib. hit(s) with all data for entry = 50039845   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385037 (CHEMBL2035600) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385035 (CHEMBL2035431) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385037 (CHEMBL2035600) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385046 (CHEMBL2035410) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1C Show InChI InChI=1S/C19H22F3NO3S/c1-13(2)23(27(25,26)17-8-6-5-7-14(17)3)16-11-9-15(10-12-16)18(4,24)19(20,21)22/h5-13,24H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385037 (CHEMBL2035600) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385051 (CHEMBL2035418) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(Br)ccc1Cl Show InChI InChI=1S/C18H18BrClF3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385035 (CHEMBL2035431) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385024 (CHEMBL2035419) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(C)ccc1Cl Show InChI InChI=1S/C19H21ClF3NO3S/c1-12(2)24(28(26,27)17-11-13(3)5-10-16(17)20)15-8-6-14(7-9-15)18(4,25)19(21,22)23/h5-12,25H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385043 (CHEMBL2035407) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C18H19F3N2O5S/c1-12(2)22(29(27,28)16-7-5-4-6-15(16)23(25)26)14-10-8-13(9-11-14)17(3,24)18(19,20)21/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385035 (CHEMBL2035431) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385039 (CHEMBL2035403) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Br Show InChI InChI=1S/C18H19BrF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385040 (CHEMBL2035404) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1F Show InChI InChI=1S/C18H19F4NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385035 (CHEMBL2035431) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385037 (CHEMBL2035600) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385047 (CHEMBL2035411) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1Cl Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)15-6-4-5-14(19)16(15)20)13-9-7-12(8-10-13)17(3,25)18(21,22)23/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385040 (CHEMBL2035404) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1F Show InChI InChI=1S/C18H19F4NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385048 (CHEMBL2035415) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(ccc1Cl)[N+]([O-])=O Show InChI InChI=1S/C18H18ClF3N2O5S/c1-11(2)23(13-6-4-12(5-7-13)17(3,25)18(20,21)22)30(28,29)16-10-14(24(26)27)8-9-15(16)19/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385057 (CHEMBL2035414) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-14(19)5-4-6-15(16)20)13-9-7-12(8-10-13)17(3,25)18(21,22)23/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385028 (CHEMBL2035423) Show SMILES CC(C)(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl Show InChI InChI=1S/C19H21ClF3NO3S/c1-17(2,3)24(28(26,27)16-8-6-5-7-15(16)20)14-11-9-13(10-12-14)18(4,25)19(21,22)23/h5-12,25H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385039 (CHEMBL2035403) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Br Show InChI InChI=1S/C18H19BrF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385049 (CHEMBL2035416) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(N)ccc1Cl Show InChI InChI=1S/C18H20ClF3N2O3S/c1-11(2)24(28(26,27)16-10-13(23)6-9-15(16)19)14-7-4-12(5-8-14)17(3,25)18(20,21)22/h4-11,25H,23H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385022 (CHEMBL2035401) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-6-4-5-14(19)11-16)15-9-7-13(8-10-15)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385048 (CHEMBL2035415) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(ccc1Cl)[N+]([O-])=O Show InChI InChI=1S/C18H18ClF3N2O5S/c1-11(2)23(13-6-4-12(5-7-13)17(3,25)18(20,21)22)30(28,29)16-10-14(24(26)27)8-9-15(16)19/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385051 (CHEMBL2035418) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(Br)ccc1Cl Show InChI InChI=1S/C18H18BrClF3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385027 (CHEMBL2035422) Show SMILES CC(O)(c1ccc(cc1)N(C1CC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C18H17ClF3NO3S/c1-17(24,18(20,21)22)12-6-8-13(9-7-12)23(14-10-11-14)27(25,26)16-5-3-2-4-15(16)19/h2-9,14,24H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385056 (CHEMBL2035412) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-9-6-13(19)10-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385024 (CHEMBL2035419) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(C)ccc1Cl Show InChI InChI=1S/C19H21ClF3NO3S/c1-12(2)24(28(26,27)17-11-13(3)5-10-16(17)20)15-8-6-14(7-9-15)18(4,25)19(21,22)23/h5-12,25H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385032 (CHEMBL2035428) Show SMILES CC(O)(c1ccc(cc1)N(C(CF)CF)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C18H17ClF5NO3S/c1-17(26,18(22,23)24)12-6-8-13(9-7-12)25(14(10-20)11-21)29(27,28)16-5-3-2-4-15(16)19/h2-9,14,26H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385023 (CHEMBL2035424) Show SMILES CC(O)(c1ccc(cc1)N(C1CCC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C19H19ClF3NO3S/c1-18(25,19(21,22)23)13-9-11-15(12-10-13)24(14-5-4-6-14)28(26,27)17-8-3-2-7-16(17)20/h2-3,7-12,14,25H,4-6H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385037 (CHEMBL2035600) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385025 (CHEMBL2035420) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(ccc1Cl)C(F)(F)F Show InChI InChI=1S/C19H18ClF6NO3S/c1-11(2)27(14-7-4-12(5-8-14)17(3,28)19(24,25)26)31(29,30)16-10-13(18(21,22)23)6-9-15(16)20/h4-11,28H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385052 (CHEMBL2035399) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C18H20F3NO3S/c1-13(2)22(26(24,25)16-7-5-4-6-8-16)15-11-9-14(10-12-15)17(3,23)18(19,20)21/h4-13,23H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385035 (CHEMBL2035431) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385055 (CHEMBL2035402) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-10-6-14(19)7-11-16)15-8-4-13(5-9-15)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385032 (CHEMBL2035428) Show SMILES CC(O)(c1ccc(cc1)N(C(CF)CF)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C18H17ClF5NO3S/c1-17(26,18(22,23)24)12-6-8-13(9-7-12)25(14(10-20)11-21)29(27,28)16-5-3-2-4-15(16)19/h2-9,14,26H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385041 (CHEMBL2035405) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1C#N Show InChI InChI=1S/C19H19F3N2O3S/c1-13(2)24(28(26,27)17-7-5-4-6-14(17)12-23)16-10-8-15(9-11-16)18(3,25)19(20,21)22/h4-11,13,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385041 (CHEMBL2035405) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1C#N Show InChI InChI=1S/C19H19F3N2O3S/c1-13(2)24(28(26,27)17-7-5-4-6-14(17)12-23)16-10-8-15(9-11-16)18(3,25)19(20,21)22/h4-11,13,25H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385042 (CHEMBL2035406) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1C(F)(F)F Show InChI InChI=1S/C19H19F6NO3S/c1-12(2)26(14-10-8-13(9-11-14)17(3,27)19(23,24)25)30(28,29)16-7-5-4-6-15(16)18(20,21)22/h4-12,27H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385027 (CHEMBL2035422) Show SMILES CC(O)(c1ccc(cc1)N(C1CC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C18H17ClF3NO3S/c1-17(24,18(20,21)22)12-6-8-13(9-7-12)23(14-10-11-14)27(25,26)16-5-3-2-4-15(16)19/h2-9,14,24H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385044 (CHEMBL2035408) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1C1CC1 Show InChI InChI=1S/C21H24F3NO3S/c1-14(2)25(17-12-10-16(11-13-17)20(3,26)21(22,23)24)29(27,28)19-7-5-4-6-18(19)15-8-9-15/h4-7,10-15,26H,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385028 (CHEMBL2035423) Show SMILES CC(C)(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl Show InChI InChI=1S/C19H21ClF3NO3S/c1-17(2,3)24(28(26,27)16-8-6-5-7-15(16)20)14-11-9-13(10-12-14)18(4,25)19(21,22)23/h5-12,25H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385026 (CHEMBL2035421) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(ccc1Cl)C1CC1 Show InChI InChI=1S/C21H23ClF3NO3S/c1-13(2)26(17-9-7-16(8-10-17)20(3,27)21(23,24)25)30(28,29)19-12-15(14-4-5-14)6-11-18(19)22/h6-14,27H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385023 (CHEMBL2035424) Show SMILES CC(O)(c1ccc(cc1)N(C1CCC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C19H19ClF3NO3S/c1-18(25,19(21,22)23)13-9-11-15(12-10-13)24(14-5-4-6-14)28(26,27)17-8-3-2-7-16(17)20/h2-3,7-12,14,25H,4-6H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385030 (CHEMBL2035426) Show SMILES CC(O)(c1ccc(cc1)N(CC1CC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C19H19ClF3NO3S/c1-18(25,19(21,22)23)14-8-10-15(11-9-14)24(12-13-6-7-13)28(26,27)17-5-3-2-4-16(17)20/h2-5,8-11,13,25H,6-7,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385025 (CHEMBL2035420) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(ccc1Cl)C(F)(F)F Show InChI InChI=1S/C19H18ClF6NO3S/c1-11(2)27(14-7-4-12(5-8-14)17(3,28)19(24,25)26)31(29,30)16-10-13(18(21,22)23)6-9-15(16)20/h4-11,28H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385040 (CHEMBL2035404) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1F Show InChI InChI=1S/C18H19F4NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385035 (CHEMBL2035431) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C18H19ClF3NO3S/c1-12(2)23(27(25,26)16-7-5-4-6-15(16)19)14-10-8-13(9-11-14)17(3,24)18(20,21)22/h4-12,24H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385037 (CHEMBL2035600) Show SMILES CC(C)N(c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C18H18Cl2F3NO3S/c1-11(2)24(28(26,27)16-10-13(19)6-9-15(16)20)14-7-4-12(5-8-14)17(3,25)18(21,22)23/h4-11,25H,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385029 (CHEMBL2035425) Show SMILES CC(O)(c1ccc(cc1)N(C1CCCC1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C20H21ClF3NO3S/c1-19(26,20(22,23)24)14-10-12-16(13-11-14)25(15-6-2-3-7-15)29(27,28)18-9-5-4-8-17(18)21/h4-5,8-13,15,26H,2-3,6-7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assay				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50385049 (CHEMBL2035416) Show SMILES CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(N)ccc1Cl Show InChI InChI=1S/C18H20ClF3N2O3S/c1-11(2)24(28(26,27)16-10-13(23)6-9-15(16)19)14-7-4-12(5-8-14)17(3,25)18(20,21)22/h4-11,25H,23H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in human HEK293 cells using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintilla...				Bioorg Med Chem Lett 22: 3786-90 (2012) Article DOI: 10.1016/j.bmcl.2012.04.005 BindingDB Entry DOI: 10.7270/Q21V5G07
					More data for this Ligand-Target Pair

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