Compile Data Set for Download or QSAR

Found 32 hits Enz. Inhib. hit(s) with all data for entry = 50026982   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264620 (CHEMBL518979 | N-(4-tert-Butylphenyl)-1-(3-(triflu...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C(F)(F)F)cc1 |t:11| Show InChI InChI=1S/C22H24F3N3O/c1-21(2,3)16-6-8-17(9-7-16)27-20(29)15-10-13-28(14-11-15)19-18(22(23,24)25)5-4-12-26-19/h4-10,12H,11,13-14H2,1-3H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264703 (CHEMBL522425 | N-(4-(Trifluoromethyl)phenyl)-1-(3-...) Show SMILES FC(F)(F)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C(F)(F)F)cc1 |t:11| Show InChI InChI=1S/C19H15F6N3O/c20-18(21,22)13-3-5-14(6-4-13)27-17(29)12-7-10-28(11-8-12)16-15(19(23,24)25)2-1-9-26-16/h1-7,9H,8,10-11H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264621 (CHEMBL482835 | N-(4-tert-Butylphenyl)-1-(3-chlorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2Cl)cc1 |t:11| Show InChI InChI=1S/C21H24ClN3O/c1-21(2,3)16-6-8-17(9-7-16)24-20(26)15-10-13-25(14-11-15)19-18(22)5-4-12-23-19/h4-10,12H,11,13-14H2,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264668 (CHEMBL491234 | N-(4-tert-Butylphenyl)-1-(pyrimidin...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccn2)cc1 |t:11| Show InChI InChI=1S/C20H24N4O/c1-20(2,3)16-5-7-17(8-6-16)23-18(25)15-9-13-24(14-10-15)19-21-11-4-12-22-19/h4-9,11-12H,10,13-14H2,1-3H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264667 (CHEMBL491036 | N-(4-tert-Butylphenyl)-1-(thiazol-2...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2nccs2)cc1 |t:11| Show InChI InChI=1S/C19H23N3OS/c1-19(2,3)15-4-6-16(7-5-15)21-17(23)14-8-11-22(12-9-14)18-20-10-13-24-18/h4-8,10,13H,9,11-12H2,1-3H3,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264581 ((R)-1-(1H-indazol-4-yl)-3-(5-(piperidin-1-yl)-2,3-...) Show SMILES O=C(N[C@@H]1CCc2cc(ccc12)N1CCCCC1)Nc1cccc2[nH]ncc12 |r| Show InChI InChI=1S/C22H25N5O/c28-22(24-19-5-4-6-21-18(19)14-23-26-21)25-20-10-7-15-13-16(8-9-17(15)20)27-11-2-1-3-12-27/h4-6,8-9,13-14,20H,1-3,7,10-12H2,(H,23,26)(H2,24,25,28)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20466 (A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...) Show SMILES FC(F)(F)c1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |c:14| Show InChI InChI=1S/C19H15F6N3O3S/c20-18(21,22)15-2-1-9-26-16(15)28-10-7-12(8-11-28)17(29)27-13-3-5-14(6-4-13)32(30,31)19(23,24)25/h1-7,9H,8,10-11H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR assay				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264666 (CHEMBL491035 | N-(4-tert-Butylphenyl)-1-(3-fluorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2F)cc1 |t:11| Show InChI InChI=1S/C21H24FN3O/c1-21(2,3)16-6-8-17(9-7-16)24-20(26)15-10-13-25(14-11-15)19-18(22)5-4-12-23-19/h4-10,12H,11,13-14H2,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264702 (CHEMBL489400 | N-(4-Chlorophenyl)-1-(3-(trifluorom...) Show SMILES FC(F)(F)c1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(Cl)cc1 |c:14| Show InChI InChI=1S/C18H15ClF3N3O/c19-13-3-5-14(6-4-13)24-17(26)12-7-10-25(11-8-12)16-15(18(20,21)22)2-1-9-23-16/h1-7,9H,8,10-11H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20466 (A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...) Show SMILES FC(F)(F)c1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |c:14| Show InChI InChI=1S/C19H15F6N3O3S/c20-18(21,22)15-2-1-9-26-16(15)28-10-7-12(8-11-28)17(29)27-13-3-5-14(6-4-13)32(30,31)19(23,24)25/h1-7,9H,8,10-11H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264665 (CHEMBL491034 | N-(4-tert-Butylphenyl)-1-(pyridin-2...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ccccn2)cc1 |t:11| Show InChI InChI=1S/C21H25N3O/c1-21(2,3)17-7-9-18(10-8-17)23-20(25)16-11-14-24(15-12-16)19-6-4-5-13-22-19/h4-11,13H,12,14-15H2,1-3H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50264581 ((R)-1-(1H-indazol-4-yl)-3-(5-(piperidin-1-yl)-2,3-...) Show SMILES O=C(N[C@@H]1CCc2cc(ccc12)N1CCCCC1)Nc1cccc2[nH]ncc12 |r| Show InChI InChI=1S/C22H25N5O/c28-22(24-19-5-4-6-21-18(19)14-23-26-21)25-20-10-7-15-13-16(8-9-17(15)20)27-11-2-1-3-12-27/h4-6,8-9,13-14,20H,1-3,7,10-12H2,(H,23,26)(H2,24,25,28)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR assay				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264128 (CHEMBL488972 | N-(4-Chlorophenyl)-1-(3-chloropyrid...) Show SMILES Clc1ccc(NC(=O)C2=CCN(CC2)c2ncccc2Cl)cc1 |t:8| Show InChI InChI=1S/C17H15Cl2N3O/c18-13-3-5-14(6-4-13)21-17(23)12-7-10-22(11-8-12)16-15(19)2-1-9-20-16/h1-7,9H,8,10-11H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264258 (1-(3-Methylpyridin-2-yl)-N-(4-(trifluoromethylsulf...) Show SMILES Cc1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |c:11| Show InChI InChI=1S/C19H18F3N3O3S/c1-13-3-2-10-23-17(13)25-11-8-14(9-12-25)18(26)24-15-4-6-16(7-5-15)29(27,28)19(20,21)22/h2-8,10H,9,11-12H2,1H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264705 (CHEMBL491241 | N-(4-(2-Cyanopropan-2-yl)phenyl)-1-...) Show SMILES CC(C)(C#N)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C(F)(F)F)cc1 |t:12| Show InChI InChI=1S/C22H21F3N4O/c1-21(2,14-26)16-5-7-17(8-6-16)28-20(30)15-9-12-29(13-10-15)19-18(22(23,24)25)4-3-11-27-19/h3-9,11H,10,12-13H2,1-2H3,(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264182 (1-(3-Chloropyridin-2-yl)-N-(4-(trifluoromethylsulf...) Show SMILES FC(F)(F)S(=O)(=O)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2Cl)cc1 |t:14| Show InChI InChI=1S/C18H15ClF3N3O3S/c19-15-2-1-9-23-16(15)25-10-7-12(8-11-25)17(26)24-13-3-5-14(6-4-13)29(27,28)18(20,21)22/h1-7,9H,8,10-11H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50160036 (CHEMBL183121 | N-(4-tert-Butyl-phenyl)-4-pyridin-2...) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1 Show InChI InChI=1S/C22H22N2O/c1-22(2,3)18-11-13-19(14-12-18)24-21(25)17-9-7-16(8-10-17)20-6-4-5-15-23-20/h4-15H,1-3H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264704 (1-(3-(Trifluoromethyl)pyridin-2-yl)-N-(6-(trifluor...) Show SMILES FC(F)(F)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C(F)(F)F)cn1 |t:11| Show InChI InChI=1S/C18H14F6N4O/c19-17(20,21)13-2-1-7-25-15(13)28-8-5-11(6-9-28)16(29)27-12-3-4-14(26-10-12)18(22,23)24/h1-5,7,10H,6,8-9H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264260 (1-(Pyrimidin-2-yl)-N-(4-(trifluoromethylsulfonyl)-...) Show SMILES FC(F)(F)S(=O)(=O)c1ccc(NC(=O)C2=CCN(CC2)c2ncccn2)cc1 |t:14| Show InChI InChI=1S/C17H15F3N4O3S/c18-17(19,20)28(26,27)14-4-2-13(3-5-14)23-15(25)12-6-10-24(11-7-12)16-21-8-1-9-22-16/h1-6,8-9H,7,10-11H2,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264257 (1-(3-Fluoropyridin-2-yl)-N-(4-(trifluoromethylsulf...) Show SMILES Fc1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |c:11| Show InChI InChI=1S/C18H15F4N3O3S/c19-15-2-1-9-23-16(15)25-10-7-12(8-11-25)17(26)24-13-3-5-14(6-4-13)29(27,28)18(20,21)22/h1-7,9H,8,10-11H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264664 (CHEMBL491033 | N-(4-tert-Butylphenyl)-1-(3-cyanopy...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ncccc2C#N)cc1 |t:11| Show InChI InChI=1S/C22H24N4O/c1-22(2,3)18-6-8-19(9-7-18)25-21(27)16-10-13-26(14-11-16)20-17(15-23)5-4-12-24-20/h4-10,12H,11,13-14H2,1-3H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264129 (CHEMBL488782 | N-(4-Chloro-3-fluorophenyl)-1-(3-ch...) Show SMILES Fc1cc(NC(=O)C2=CCN(CC2)c2ncccc2Cl)ccc1Cl |t:7| Show InChI InChI=1S/C17H14Cl2FN3O/c18-13-4-3-12(10-15(13)20)22-17(24)11-5-8-23(9-6-11)16-14(19)2-1-7-21-16/h1-5,7,10H,6,8-9H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264259 (1-(Thiazol-2-yl)-N-(4-(trifluoromethylsulfonyl)phe...) Show SMILES FC(F)(F)S(=O)(=O)c1ccc(NC(=O)C2=CCN(CC2)c2nccs2)cc1 |t:14| Show InChI InChI=1S/C16H14F3N3O3S2/c17-16(18,19)27(24,25)13-3-1-12(2-4-13)21-14(23)11-5-8-22(9-6-11)15-20-7-10-26-15/h1-5,7,10H,6,8-9H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264130 (1-(3-Chloropyridin-2-yl)-N-(3,4-dichlorophenyl)-1,...) Show SMILES Clc1ccc(NC(=O)C2=CCN(CC2)c2ncccc2Cl)cc1Cl |t:8| Show InChI InChI=1S/C17H14Cl3N3O/c18-13-4-3-12(10-15(13)20)22-17(24)11-5-8-23(9-6-11)16-14(19)2-1-7-21-16/h1-5,7,10H,6,8-9H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264619 (Biphenyl-4-carboxylic acid (3-methoxy-phenyl)-amid...) Show SMILES COc1cccc(NC(=O)c2ccc(cc2)-c2ccccc2)c1 Show InChI InChI=1S/C20H17NO2/c1-23-19-9-5-8-18(14-19)21-20(22)17-12-10-16(11-13-17)15-6-3-2-4-7-15/h2-14H,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264261 (CHEMBL491816 | N-(4-tert-Butylphenyl)-1-(3-chlorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C21H26ClN3O/c1-21(2,3)16-6-8-17(9-7-16)24-20(26)15-10-13-25(14-11-15)19-18(22)5-4-12-23-19/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	196	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264701 (CHEMBL489399 | N-(4-tert-Butylphenyl)-1-(2-fluorop...) Show SMILES CC(C)(C)c1ccc(NC(=O)C2=CCN(CC2)c2ccccc2F)cc1 |t:11| Show InChI InChI=1S/C22H25FN2O/c1-22(2,3)17-8-10-18(11-9-17)24-21(26)16-12-14-25(15-13-16)20-7-5-4-6-19(20)23/h4-12H,13-15H2,1-3H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	265	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264131 (CHEMBL522969 | N-(4-Chloro-2-fluorophenyl)-1-(3-ch...) Show SMILES Fc1cc(Cl)ccc1NC(=O)C1=CCN(CC1)c1ncccc1Cl |t:12| Show InChI InChI=1S/C17H14Cl2FN3O/c18-12-3-4-15(14(20)10-12)22-17(24)11-5-8-23(9-6-11)16-13(19)2-1-7-21-16/h1-5,7,10H,6,8-9H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	618	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50264132 (CHEMBL491226 | N-(4-Chloro-2-(trifluoromethyl)phen...) Show SMILES FC(F)(F)c1cc(Cl)ccc1NC(=O)C1=CCN(CC1)c1ncccc1Cl |t:15| Show InChI InChI=1S/C18H14Cl2F3N3O/c19-12-3-4-15(13(10-12)18(21,22)23)25-17(27)11-5-8-26(9-6-11)16-14(20)2-1-7-24-16/h1-5,7,10H,6,8-9H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20466 (A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...) Show SMILES FC(F)(F)c1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |c:14| Show InChI InChI=1S/C19H15F6N3O3S/c20-18(21,22)15-2-1-9-26-16(15)28-10-7-12(8-11-28)17(29)27-13-3-5-14(6-4-13)32(30,31)19(23,24)25/h1-7,9H,8,10-11H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	5.5	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of pH 5.5-induced calcium influx by FLIPR assay				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20466 (A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...) Show SMILES FC(F)(F)c1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |c:14| Show InChI InChI=1S/C19H15F6N3O3S/c20-18(21,22)15-2-1-9-26-16(15)28-10-7-12(8-11-28)17(29)27-13-3-5-14(6-4-13)32(30,31)19(23,24)25/h1-7,9H,8,10-11H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of N-arachidonoyldopamine-induced calcium influ...				Bioorg Med Chem 16: 8516-25 (2008) Article DOI: 10.1016/j.bmc.2008.08.005 BindingDB Entry DOI: 10.7270/Q2FX798X
					More data for this Ligand-Target Pair